N-tert-Butyl-α-phenylnitrone - ≥95% , CAS No.3376-24-7

CAS: 3376-24-7 Cat. No.: B100838 Peso molecular: 177.24 Beilstein Registry Number: 2044028 Número EC: 222-168-6
Disponible para pedir
GRADE & PURITY ≥95%
Synonyms
PBN | Phenyl-N-tert-butylnitrone | F0001-0991 | 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide, (N(Z))- | N-tert-Butyl-.alpha.-phenylnitrone | (Z)-N-Benzylidene-2-methylpropan-2-amine oxide | n-tert-butyl phenyl nitrone | (Z)-benzylidene(tert-butyl
Storage
Store at -20°C,Argon charged
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1g
B100838-1g
2
49,90US$
5g
B100838-5g
3
184,90US$
25g
B100838-25g
2
829,90US$
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

N-tert-butyl-α-phenylnitro?ne (PBN) is a commonly used free-radical spin trap. It has been shown to reduce the number of emboli-induced cerebral microinfarctions in the rabbit cortex and prevent neoplasia by its radical scavenging activity and its ability to inhibit cyclooxygenase-2 activity. Reported to inhibit the induction of nitric oxide synthase (iNOS), thereby preventing the overproduction of nitric oxide (NO). PBN in a dose of 100 mg/kg i.p. reduced necrosis of the substantia nigra, pars reticulate in flurothyl-induced status epilepticus in rats. It protects against some types of post-trauma epileptogenic events in an animal model of epilepsy.The lethal dose of PBN in rats was found to be approximately 100 mg/100 g body weight (0.564 mmol/100? g).
A Cox-2 inhibitor.

Specifications

Sinónimos
PBN | Phenyl-N-tert-butylnitrone | F0001-0991 | 2-Propanamine, 2-methyl-N-(phenylmethylene)-, N-oxide, (N(Z))- | N-tert-Butyl-.alpha.-phenylnitrone | (Z)-N-Benzylidene-2-methylpropan-2-amine oxide | n-tert-butyl phenyl nitrone | (Z)-benzylidene(tert-butyl
Especificaciones y pureza
≥95%
Mecanismos bioquímicos y fisiológicos
Cell permeable\xa0free radicle\xa0trap. Inhibits LPS-induced NF-κB DNA binding activity, inhibits COX-2 catalytic activity and inhibits lipid peroxidation in rat liver microsomes. Blocks indiction of iNOS by reactive oxygen species.
Condiciones de almacenamiento de almacenamiento
Store at -20°C, Argon charged
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
INHIBITOR
Nota
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Pureza
≥95%
Nombres e identificadores
Pubchem Sid504759662
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504759662
Sonrisas canónicasCC(C)(C)[N+](=CC1=CC=CC=C1)[O-]
IUPAC NameN-tert-butyl-1-phenylmethanimine oxide
InChIKeyIYSYLWYGCWTJSG-XFXZXTDPSA-N
INCHI1S/C11H15NO/c1-11(2,3)12(13)9-10-7-5-4-6-8-10/h4-9H,1-3H3/b12-9-
Isómeros SMILES CC(C)(C)/[N+](=C/C1=CC=CC=C1)/[O-]
WGK Alemania 3
RTECS TX1760000
Peso molecular 177.24
Beilstein 2044028
Reaxy-Rn 2044028
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2044028&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassBenzenoids
ClaseBenzene and substituted derivatives
SubclassNot available
Intermediate Tree Nodes Not available
Direct ParentBenzene and substituted derivatives
Alternative Parents Shiff bases  Nitrones  Propargyl-type 1,3-dipolar organic compounds  Organopnictogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic homomonocyclic compounds
Substituents Monocyclic benzene moiety - Shiff base - Nitrone - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organonitrogen compound - Aromatic homomonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as benzene and substituted derivatives. These are aromatic compounds containing one monocyclic ring system consisting of benzene.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





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Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeFechaArticulo
D2621027Certificate of AnalysisApr 29, 2026 B100838
I2517066Certificate of AnalysisSep 22, 2025 B100838
E2516796Certificate of AnalysisMay 20, 2025 B100838
F2229267Certificate of AnalysisApr 02, 2025 B100838
F2229437Certificate of AnalysisApr 02, 2025 B100838
F2229439Certificate of AnalysisApr 02, 2025 B100838
E2114030Certificate of AnalysisFeb 06, 2024 B100838
L2413168Certificate of AnalysisFeb 06, 2024 B100838
L2413210Certificate of AnalysisJun 06, 2022 B100838
C2211230Certificate of AnalysisMar 14, 2022 B100838
Propiedades químicas y físicas
SolubilidadSoluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).
SensibilidadAir Sensitive
Punto de fusión (°C)72-75°C
Peso molecular177.240 g/mol
XLogP31.300
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count1
Rotatable Bond Count2
Exact Mass177.115 Da
Monoisotopic Mass177.115 Da
Topological Polar Surface Area28.800 Ų
Heavy Atom Count13
Formal Charge0
Complexity185.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds1
Covalently-Bonded Unit Count1
Citations of This Product
Referencias
1. Zening Zhang, Peng Deng, Yang Chen, Zhiyong He, Fang Qin, Qiuming Chen, Zhaojun Wang, Jie Chen, Maomao Zeng, Hongyang Pan.  (2023)  Exploration of the synergistic inhibition of 4-methylimidazole and 5-hydroxymethylfurfural in caramel colors by amino acid combinations and potential mechanisms.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2023.103471]
2. Ming Yuan, Dayun Huang, Zefeng Wang, Xin Chen, Minghua Yang.  (2022)  Synthesis of ultra-high molecular weight poly(methyl methacrylate) with hydrosilane as initiator.  Materials Today Communications,      [PMID:] [10.1016/j.mtcomm.2022.104927]
3. Hao-Xiang Gao, Nan Chen, Qiang He, Bi Shi, Zhi-Long Yu, Wei-Cai Zeng.  (2022)  Effects of Ligustrum robustum (Rxob.) Blume extract on the quality of peanut and palm oils during storage and frying process.  JOURNAL OF FOOD SCIENCE,  87  (10): (4504-4521).  [PMID:36124403] [10.1111/1750-3841.16311]
4. Yingjie Ma, Hairong Huang, Yan Zhang, Feng Li, Bei Gan, Qiang Yu, Jianhua Xie, Yi Chen.  (2022)  Soluble dietary fiber from tea residues with inhibitory effects against acrylamide and 5-hydroxymethylfurfural formation in biscuits: The role of bound polyphenols.  FOOD RESEARCH INTERNATIONAL,      [PMID:35940761] [10.1016/j.foodres.2022.111595]
5. Zhou Yulan, Liao Wanfeng, Ni Xiuyuan.  (2020)  Cationic Photopolymerization Initiated by a Photocatalytic Complex Sensitive to Visible Light at 520 nm.  CATALYSIS LETTERS,  151  (6): (1766-1775).  [PMID:] [10.1007/s10562-020-03437-z]
6. Wanfeng Liao, Xiuyuan Ni, Yulan Zhou.  (2018)  Cationic and free radical polymerization initiated by a visible-light sensitive complex based on the photocatalytic decarboxylation of carboxylic acid.  JOURNAL OF CATALYSIS,      [PMID:] [10.1016/j.jcat.2018.03.005]
7. Yongxi Deng, Kecheng Zhu, Wenjun Jiang, Yixuan Liu, Linyang Xie, Fuhao Liu, Kangjie Yang, Yuanren Jiang, Hanzhong Jia.  (2024)  Novel Chemical Routes for Carbon Dioxide and Methane Production from Lignin Photodegradation: The Role of Environmental Free Radicals.  ENVIRONMENTAL SCIENCE & TECHNOLOGY,      [PMID:39205644] [10.1021/acs.est.4c03414]
8. Nuo Cheng, Fu Deng, Jinlong Wang, Longfeng Hu, Jiaxuan Yang, Shu Jiang, Hesong Wang, Xiaofei Ma, Lei Zhao, Guibai Li, Han Zhang, Heng Liang.  (2024)  Simultaneous alkali recovery, coagulant recycling and organics removal from textile wastewater via membrane electrochemical system.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2024.129448]
9. Zhaofen Xu, Lingfang Tang, Yuanyi Zhou, Gang Lu, Haojie Dong, Mingshan Zhu.  (2024)  Utilizing the immanent chloride ions in wastewater for reactive chlorine species photogeneration towards effective ammonia nitrogen removal.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.152589]
10. Luo Xiongfei, Liu Xue, Guo Hongda, Li Ruiping, Wang Min, Li Xiaotong, Li Shujun, Liu Shouxin, Li Jian, Strehmel Veronika, Wang Qunying, Yilmaz Gorkem, Matyjaszewski Krzysztof, Strehmel Bernd, Chen Zhijun.  (2025)  Biomass-derived carbon dots for the initiation of conventional radical and ATRP-based photopolymerization processes.  Nature Protocols,      [PMID:40760038] [10.1038/s41596-025-01210-3]
11. Yicheng Fan, Xiuyuan Ni, Wenbin Fu.  (2025)  Photocatalyzed ring-opening polymerization of ε-caprolactone.  Catalysis Science & Technology,      [PMID:] [10.1039/D5CY00845J]
12. Libin Sun, Zhe Huang, Junguo Wang, Dianyu Yu, Liqi Wang.  (2024)  Effect of deodorization conditions on fatty acid profile, oxidation products, and lipid-derived free radicals of soybean oil.  FOOD CHEMISTRY,      [PMID:38788646] [10.1016/j.foodchem.2024.139656]
13. Peng Deng, Qifan Wang, Shengfang Wu, Xiuwen Zhou, Fatih Oz, Qiuming Chen, Zhaojun Wang, Zhiyong He, Jie Chen, Maomao Zeng.  (2025)  Synergistic effect of spice extracts on multiple hazards formation and sensory markers in beef flavoring.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106099]
14. Yu-Dong Shan, Yu-Le Wang, Qing He, Yi-Fang Lu, Song-Hai Wu, Yong Liu, Xu Han.  (2025)  Selective Photooxidation of Cyclohexane to KA-Oil by Mo-Doped Mesoporous TiO2 and the Role of Electron-Shuttling Quinones.  ACS Catalysis,      [PMID:] [10.1021/acscatal.5c01245]
15. Ying Luo, Jie Xu, Ying-Chen Fan, Zong-Han Wang, Yuan-Yuan Hu, De-Yang Li, Yu-Xin Liu, Da-Yong Zhou.  (2025)  Effect of lipid oxidation on the color deterioration of ready-to-eat oysters: Discussion based on the model system.  FOOD CHEMISTRY,      [PMID:41218311] [10.1016/j.foodchem.2025.147024]
16. Yuan Ming, Han Xiaofang, Zhang Zekai, Wang Ruijia, Guo Shengrong.  (2025)  Synthesis of ultra-high molecular weight poly(methyl methacrylate) initiated by the combination of copper nanopowder with organic halides.  BMC Chemistry,  19  (1): (223).  [PMID:40713622] [10.1186/s13065-025-01597-w]
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