N3-Ph-NHS ester - ≥98% , CAS No.53053-08-0

CAS: 53053-08-0 Cat. No.: N596951 Peso molecular: 260.21 Número EC: 892-311-0 PubChem CID: 122153

GRADE & PURITY ≥98%

Synonyms

YSZCJ045 | 4-Azidobenzoic acid N-hydroxysuccinimide ester | n-(4-azidobenzoyloxy)succinimide | HY-126524 | 4-Azidobenzoyloxysuccinimide | N-HYDROXYSUCCINIMIDE 4-AZIDOBENZOIC ESTER | 2,5-DIOXOPYRROLIDIN-1-YL 4-AZIDOBENZOATE | 3-hydroxy-2,5-dioxopyrrolidin-

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

N-Hydroxysuccinimidyl-4-azidobenzoate is an aryl azide-based, amine- and photoreactive crosslinker.

Product description：

N3-Ph-NHS ester is a noncleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-Ph-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

Specifications

Sinónimos

YSZCJ045 | 4-Azidobenzoic acid N-hydroxysuccinimide ester | n-(4-azidobenzoyloxy)succinimide | HY-126524 | 4-Azidobenzoyloxysuccinimide | N-HYDROXYSUCCINIMIDE 4-AZIDOBENZOIC ESTER | 2, 5-DIOXOPYRROLIDIN-1-YL 4-AZIDOBENZOATE | 3-hydroxy-2, 5-dioxopyrrolidin-

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: C1CC(=O)N(C1=O)OC(=O)C2=CC=C(C=C2)N=[N+]=[N-]
• IUPAC Name: (2,5-dioxopyrrolidin-1-yl) 4-azidobenzoate
• InChIKey: LWAVGNJLLQSNNN-UHFFFAOYSA-N
• INCHI: 1S/C11H8N4O4/c12-14-13-8-3-1-7(2-4-8)11(18)19-15-9(16)5-6-10(15)17/h1-4H,5-6H2
• Isómeros SMILES: C1CC(=O)N(C1=O)OC(=O)C2=CC=C(C=C2)N=[N+]=[N-]
• PubChem CID: 122153
• Peso molecular: 260.21

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Benzoic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Benzoic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzoic acids and derivatives
• Alternative Parents: Phenylazides Benzoyl derivatives Pyrrolidine-2-ones Dicarboximides Azo compounds Azo imides Lactams Carboxylic acid salts Azacyclic compounds Monocarboxylic acids and derivatives Hydrocarbon derivatives Carbonyl compounds Organic oxides Organic salts Organic zwitterions Organopnictogen compounds
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Benzoic acid or derivatives - Benzoyl - Phenylazide - 2-pyrrolidone - Pyrrolidone - Dicarboximide - Pyrrolidine - Azo compound - Azo imide - Carboxylic acid salt - Lactam - Carboxylic acid derivative - Azacycle - Organoheterocyclic compound - Monocarboxylic acid or derivatives - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Carbonyl group - Organic oxide - Organonitrogen compound - Organooxygen compound - Organic salt - Organic zwitterion - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzoic acids and derivatives. These are organic compounds containing a carboxylic acid substituent attached to a benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Sensibilidad: Light sensitive，Moisture sensitive，Heat sensitive
• Punto de fusión (°C): 164 °C
• Peso molecular: 260.209 g/mol
• XLogP3: 1.800
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 260.055 Da
• Monoisotopic Mass: 260.055 Da
• Topological Polar Surface Area: 78.000 Ų
• Heavy Atom Count: 19
• Formal Charge: 0
• Complexity: 434.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1