Namitecan - 10mM in DMSO , CAS No.372105-27-6

CAS: 372105-27-6 Cat. No.: N655466 Peso molecular: 434.44 PubChem CID: 10950142

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Namitecan is a potent topoisomerase I inhibitor, with antitumor property.

In Vitro

Namitecan and cetuximab cooperate in inhibiting EGFR expression. Namitecan induces a dose-dependent decrease in EGFR expression in the different cell lines. ST1968 induces a comparable level of apoptosis in A431 and A431/TPT cells with IC 50 of 0.21 and 0.29 μM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Namitecan (10 mg/kg) in combination with cetuximab (1 mg/mouse) induces synergistic antitumor effects in SCC models as a function of EGFR gene copy number . ST1968 (25 mg/kg) causes acceptable body weight loss and no toxic deaths. ST1968 produces a 100% complete response rate in the mice bearing the A431 tumor, and retains a relevant activity in the topotecan-resistant tumor. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Topoisomerase I

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Namitecan is a potent topoisomerase I inhibitor, with antitumor property.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)/C=N/OCCN)O
• CAS alternativo: 372105-27-6
• PubChem CID: 10950142
• Términos de entrada MeSH: namitecan;ST 1968;ST-1968;ST1968
• Peso molecular: 434.44