Nampt-IN-5 - 10mM in DMSO , CAS No.2380013-17-0

CAS: 2380013-17-0 Cat. No.: N656732 Peso molecular: 427.50 PubChem CID: 146014464

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively

In Vitro

Nampt-IN-5 (compound 27) (0-10 nM; 3 days) has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively. Nampt-IN-5 shows a good ADME data: mouse microsomal clearance (110 μl/min•mg), CYP3A4 inhibition value (0.75 μM), Sol 6.8 : 0.056 mM; MDCK P app AB: 18.6. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nampt-IN-5 (5-30 mg/kg; p.o. twice daily for 4 days) causes a significant amount of body weight loss in nude mice relative to vehicle . Nampt-IN-5 (10 mg/kg; p.o.) exhibits T 1/2 (2.1 h), C max (29112 nM), and AUC (61984 nM•h) in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:NAMPT, CYP3A4

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC 50 s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: CCOC1=NC2=CC=CC=C2N1CC3=CC=C(C=C3)NC(=O)N4CC(C4)C5=CN=CC=C5
• PubChem CID: 146014464
• Peso molecular: 427.50