GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Napabucasin (BBI608) is an orally availableStat3and cancer cell stemness inhibitor. In vitro
Napabucasin downregulates stemness gene expression driven by Stat3 and cancer stemness properties, and effectively inhibits self-renewal of stemness-high cancer cells with IC50 ranged from 0.291~1.19 μM, on inhibition on normal stem cells.
In vivo
In mice bearing PaCa-2 xenografts, Napabucasin (20 mg/kg, i.p.) significantly inhibits tumor growth, relapse and metastasis. Cell Data
cell lines：
Concentrations：~2 μM
Incubation Time：72 h
Powder Purity:≥99%
Specifications
Sinónimos
BBI608 | 2-acetylnaphtho[2, 3-b]furan-4, 9-dione
Especificaciones y pureza
Moligand™, 10mM in DMSO
Mecanismos bioquímicos y fisiológicos
Napabucasin (BBI608) is an orally available Stat3 and cancer cell stemness inhibitor.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
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