Naproxen Sodium - Moligand™,10mM in DMSO , Cyclooxygenase inhibitor, CAS No.26159-34-2, Cyclooxygenase inhibitor

CAS: 26159-34-2 Cat. No.: N407750 Peso molecular: 252.24 Número EC: 247-486-2

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

RS-3650 | sodium (S)-2-(6-methoxynaphthalen-2-yl)propanoate

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Naproxen Sodium (RS-3650) is a COX inhibitor forCOX-1andCOX-2withIC50of 8.7 μM and 5.2 μM, respectively.
In vitro

Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50 of 2.2 μg/mL and 1.3 μg/mL, respectively. Naproxen decreases the in vitro LPS-induced PGE₂ and TXB₂ production in rats and humans with IC50 of 30.7 μM and 79.5 μM for PGE₂ inhibition, 72.4 μM and 48.3 μM for TXB₂ inhibition, respectively. Naproxen produces concentration-related inhibition of TXB₂ production from human platelets and LPS-induced TXB₂ production from human mononuclear cells with plC50 values (-log concentration inhibiting TXB₂ by 50%) of 5.7 and 6.4, respectively, and exhibits slightly inhibitory selectivity for constitutive and induced COX-2 with IC50 COX-1/IC50 COX-2 of 6.3. Only high concentration of Naproxen can significantly induce apoptosis at 48 hours in HCA-7 colon cancer cells with IC50 of 1.45 mM.

In vivo

Administration of Naproxen reduces the LPS-induced PGE₂ and TXB₂ production in vivo in rats with IC50 values of 12.8 μM and 5.9 μM, respectively, which represents that Naproxen is a nonselective COX inhibitor with the log IC50 ratio (COX-2/COX-1) of 0.34. Naproxen displays IC50 of 27 μM for analgesia in a rat model with carrageenan-induced arthritis and IC50 of 40 μM for antipyretics in a yeast-induced fever rat model, while exhibits inhibition of PGE₂ with IC50 of 13 μM and TXB₂ with IC50 of 5 μM.
Cell Data

cell lines：

Concentrations：Dissolved in culture medium, final concentration ~20 mM

Incubation Time：24 and 48 hours

Powder Purity:≥99%

Specifications

Sinónimos

RS-3650 | sodium (S)-2-(6-methoxynaphthalen-2-yl)propanoate

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Naproxen Sodium (RS-3650) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Cyclooxygenase inhibitor

Nombres e identificadores

• Isómeros SMILES: C[C@@H](C1=CC2=C(C=C1)C=C(C=C2)OC)C(=O)[O-].[Na+]
• WGK Alemania: 3
• RTECS: QJ1047000
• Peso molecular: 252.24
• Reaxy-Rn: 4282250
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4282250&ln=

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro
• Punto de fusión (°C): 259-262°C

Referencias

1. Daikun Li, Wei Zhan, Xinlei Gao, Qi Wang, LiPin Li, Jun Zhang, Guiyuan Cai, Wei Zuo, Yu Tian.  (2022)  Aminated waste paper membrane for efficient and rapid filtration of anionic dyes and antibiotics from water.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2022.140641]

2. Weiyingxue Yang, Chuixiu Huang, Xiantao Shen.  (2022)  Water-compatible Janus molecularly imprinted particles with mouth-like opening: Rapid removal of pharmaceuticals from hospital effluents.  CHEMOSPHERE,      [PMID:35714963] [10.1016/j.chemosphere.2022.135350]

3. Ruiqin Zhu, Hang Mei, Huajing Liu, Changbao Hong, Xiantao Shen, Chuixiu Huang.  (2021)  Successive liquid-phase microextraction of acidic and basic analytes.  ANALYTICA CHIMICA ACTA,      [PMID:35057942] [10.1016/j.aca.2021.339335]