Navocaftor - ≥99% , Cystic fibrosis transmembrane conductance regulator positive modulator, CAS No.2159103-66-7, Cystic fibrosis transmembrane conductance regulator positive modulator

CAS: 2159103-66-7 Cat. No.: N651324 Peso molecular: 416.33 PubChem CID: 132189640

GRADE & PURITY ≥99%

Synonyms

Navocaftor | CHEMBL4802150 | Navocaftor [USAN:INN] | [5-[3-amino-5-[4-(trifluoromethoxy)phenyl]sulfonylpyridin-2-yl]-1,3,4-oxadiazol-2-yl]methanol | ABBV-3067 | MS-27234 | 1,3,4-Oxadiazole-2-methanol, 5-(3-amino-5-((4-(trifluoromethoxy)phenyl)sulfonyl)-2-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator (US 20200377491 Al, example 1)

In Vitro

Navocaftor, as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:CFTR

Specifications

Sinónimos

Navocaftor | CHEMBL4802150 | Navocaftor [USAN:INN] | [5-[3-amino-5-[4-(trifluoromethoxy)phenyl]sulfonylpyridin-2-yl]-1, 3, 4-oxadiazol-2-yl]methanol | ABBV-3067 | MS-27234 | 1, 3, 4-Oxadiazole-2-methanol, 5-(3-amino-5-((4-(trifluoromethoxy)phenyl)sulfonyl)-2-

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator ( CFTR ), is a protein modulator (US 20200377491 Al, example 1).

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

POSITIVE MODULATOR

Mecanismo de acción

Cystic fibrosis transmembrane conductance regulator positive modulator

Pureza

≥99%

Propiedades del producto

• ALogP: 0.8

Nombres e identificadores

• Sonrisas canónicas: C1=CC(=CC=C1OC(F)(F)F)S(=O)(=O)C2=CC(=C(N=C2)C3=NN=C(O3)CO)N
• IUPAC Name: [5-[3-amino-5-[4-(trifluoromethoxy)phenyl]sulfonylpyridin-2-yl]-1,3,4-oxadiazol-2-yl]methanol
• InChIKey: WOXOLLSAICIZNO-UHFFFAOYSA-N
• INCHI: 1S/C15H11F3N4O5S/c16-15(17,18)27-8-1-3-9(4-2-8)28(24,25)10-5-11(19)13(20-6-10)14-22-21-12(7-23)26-14/h1-6,23H,7,19H2
• Isómeros SMILES: C1=CC(=CC=C1OC(F)(F)F)S(=O)(=O)C2=CC(=C(N=C2)C3=NN=C(O3)CO)N
• PubChem CID: 132189640
• Peso molecular: 416.33

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Benzenesulfonyl compounds

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Benzenesulfonyl compounds
• Intermediate Tree Nodes: Not available
• Direct Parent: Benzenesulfonyl compounds
• Alternative Parents: Phenoxy compounds Phenol ethers Aminopyridines and derivatives Sulfones Heteroaromatic compounds 1,3,4-oxadiazoles Trihalomethanes Oxacyclic compounds Azacyclic compounds Primary amines Primary alcohols Organopnictogen compounds Organofluorides Organic oxides Hydrocarbon derivatives Aromatic alcohols Alkyl fluorides
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Benzenesulfonyl group - Phenoxy compound - Phenol ether - Aminopyridine - Pyridine - Heteroaromatic compound - Sulfonyl - Sulfone - Oxadiazole - Azole - 1,3,4-oxadiazole - Trihalomethane - Oxacycle - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Halomethane - Hydrocarbon derivative - Aromatic alcohol - Primary amine - Primary alcohol - Organosulfur compound - Organooxygen compound - Organonitrogen compound - Organofluoride - Organohalogen compound - Amine - Alkyl halide - Alkyl fluoride - Alcohol - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as benzenesulfonyl compounds. These are aromatic compounds containing a benzenesulfonyl group, which consists of a monocyclic benzene moiety that carries a sulfonyl group.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: DMSO : <1 mg/mL (ultrasonic) (insoluble or slightly soluble)