NB-598 Maleate - 10mM in DMSO , CAS No.155294-62-5

CAS: 155294-62-5 Cat. No.: N656340 Peso molecular: 565.74

GRADE & PURITY 10mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE) , and suppresses triglyceride biosynthesis through the farnesol pathway.

In Vitro

NB-598 (10 μM) causes a 36±7% reduction in total cholesterol level of MIN6 cells. NB-598 causes a significant decrease in cholesterol by 49±2%, 46±7%, and 48±2% from PM, ER, and SG, respectively. NB598 at concentrations up to 10 μM does not affect peak outward KV currents or the voltage dependence of activation but increases current inactivation. NB-598 (10 μM) inhibits the synthesis of sterol and sterol ester from [ 14 C]acetate without affecting the synthesis of other lipids such as phospholipids (PL), free fatty acids (FFA) and triacylglycerol (TG). In the absence of exogenous liposomal cholesterol, NB-598 reduces ACAT activity by 31%. NB-598 reduces ACAT activity by 22% even in the presence of a 600 PM concentration of liposomal cholesterol. NB-598 suppresses the secretion of cholesterol and triacylglycerol from HepG2 cells into the medium. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

NB-598 Maleate is a potent and competitive inhibitor of squalene epoxidase (SE) , and suppresses triglyceride biosynthesis through the farnesol pathway.

Condiciones de almacenamiento de almacenamiento

Argon charged, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Peso molecular: 565.74