Neocryptotanshinone - ≥98% , CAS No.109664-02-0

CAS: 109664-02-0 Cat. No.: N647917 Peso molecular: 314.4

COA

Saltar al final de la galería de imágenes

Neocryptotanshinone - ≥98% CAS No(109664-02-0) by Aladdin Scientific

Saltar al comienzo de la galería de imágenes

Disponible para pedir

GRADE & PURITY ≥98%

Synonyms

AC-34912 | HY-119720 | (+)-Neocryptotanshinone | 1,4-Phenanthrenedione, 5,6,7,8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8,8-dimethyl- | BDBM50604714 | NSC686517 | NSC-686517 | AKOS040760589 | NCI60_031207 | (R)-3-Hydroxy-2-(1-hydroxypropan-2

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas

🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza , inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways

In Vitro

Neocryptotanshinone exhibits anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways. Neocryptotanshinone (10 μM and 20 μM, 24 h) inhibits LPS-induced iNOS protein expression in RAW264.7 cells. Neocryptotanshinone (20 μM, 24 h) shows no obvious cytotoxic effect towards murine RAW264.7 macrophages. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: RAW264.7 cells Concentration: 5, 10 and 20 μM Incubation Time: 24 hours Result: Inhibited LPS-induced cell viability in a dose-dependent manner. Western Blot AnalysisCell Line: RAW264.7 cells Concentration: 20 μM Incubation Time: 24 hours Result: Inhibited LPS-induced activation of NF-κB pathway and down-regulated LPS-induced expression of p-NF-κB p65, p-IκBα and p-IKKβ.

In Vivo

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: MSU-induced pain model in male ICR mice (weighing 20-25 g)Dosage: 10, 25, 50 or 100 mg/kg Administration: Oral gavage; for 30, 60, 120 min Result: Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.

Form:Solid

IC50& Target:iNOS

Specifications

Sinónimos

AC-34912 | HY-119720 | (+)-Neocryptotanshinone | 1, 4-Phenanthrenedione, 5, 6, 7, 8-tetrahydro-3-hydroxy-2-[(1R)-2-hydroxy-1-methylethyl]-8, 8-dimethyl- | BDBM50604714 | NSC686517 | NSC-686517 | AKOS040760589 | NCI60_031207 | (R)-3-Hydroxy-2-(1-hydroxypropan-2

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Neocryptotanshinone, a fatty diterpenoids from Salvia Miltiorrhiza , inhibits lipopolysaccharide-induced inflammation by suppression of NF-κB and iNOS signaling pathways.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥98%

Nombres e identificadores

Sonrisas canónicas	CC(CO)C1=C(C2=C(C3=C(C=C2)C(CCC3)(C)C)C(=O)C1=O)O
IUPAC Name	1-hydroxy-2-[(2R)-1-hydroxypropan-2-yl]-8,8-dimethyl-6,7-dihydro-5H-phenanthrene-3,4-dione
InChIKey	LGZFJHSOBYVDLA-JTQLQIEISA-N
INCHI	1S/C19H22O4/c1-10(9-20)14-16(21)12-6-7-13-11(5-4-8-19(13,2)3)15(12)18(23)17(14)22/h6-7,10,20-21H,4-5,8-9H2,1-3H3/t10-/m0/s1
Isómeros SMILES	C[C@@H](CO)C1=C(C2=C(C3=C(C=C2)C(CCC3)(C)C)C(=O)C1=O)O
CAS alternativo	109664-02-0
Número NSC	686517
Peso molecular	314.4
Reaxy-Rn	37313998
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=37313998&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Lipids and lipid-like molecules
  - Clase Prenol lipids
    - Subclass Diterpenoids

Kingdom	Organic compounds
Superclass	Lipids and lipid-like molecules
Clase	Prenol lipids
Subclass	Diterpenoids
Intermediate Tree Nodes	Not available
Direct Parent	Tanshinones, isotanshinones, and derivatives
Alternative Parents	Phenanthrols Hydrophenanthrenes Naphthoquinones Naphthols and derivatives Tetralins Quinones Aryl ketones Vinylogous acids Enols Primary alcohols Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic homopolycyclic compounds
Substituents	Tanshinone skeleton - Phenanthrol - Hydrophenanthrene - Phenanthrene - Naphthoquinone - 1-naphthol - Naphthalene - Tetralin - Aryl ketone - Quinone - Benzenoid - Vinylogous acid - Ketone - Cyclic ketone - Enol - Hydrocarbon derivative - Organic oxide - Alcohol - Organic oxygen compound - Carbonyl group - Organooxygen compound - Primary alcohol - Aromatic homopolycyclic compound
Descripción	This compound belongs to the class of organic compounds known as tanshinones, isotanshinones, and derivatives. These are a group of abietane-type norditerpenoid quinones.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

A498 (42825 Activities)

Solubilidad	DMSO : 100 mg/mL (318.09 mM; Need ultrasonic)
Peso molecular	314.400 g/mol
XLogP3	3.000
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	314.152 Da
Monoisotopic Mass	314.152 Da
Topological Polar Surface Area	74.600 Å²
Heavy Atom Count	23
Formal Charge	0
Complexity	560.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1