GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.≥98%
Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
L-NG-Monomethylarginine, Acetate Salt (L-NMMA), is an analogue of L-arginine that has been shown to inhibit Ca2+-dependent NOS3 (endothelial NOS) from porcine aorta. In an experiment on porcine aortic rings, L-NMMA was shown to cause contraction and inhibition of the endothelium-dependent relaxation induced by acetylcholine. This compound has also been noted to elicit a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. Experiments on cat vascular endothelia show that L-NMMA can increase leukocyte adherence and emigration and reduce venular shear rate. Low shear rates have been shown to promote platelet-endothelial and leukocyte-endothelial cell adhesion in mesenteric venules. L-NG-Monomethylarginine, Acetate Salt (L-NMMA) is an inhibitor of NOS1 and NOS2. An L-arginine analogue inhibitor of Ca2+-dependent NOS3 (endothelial NOS)
Cell-permeable competitive NOS inhibitor. (K i values are 700 nM, 3.9 µM and 650 nM for eNOS, iNOS and nNOS, respectively).
Condiciones de almacenamiento de almacenamiento
Store at -20°C, Argon charged
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
INHIBITOR
Mecanismo de acción
Nitric oxide synthase inhibitor
Nota
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This compound belongs to the class of organic compounds known as arginine and derivatives. These are compounds containing arginine or a derivative thereof resulting from reaction of arginine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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