Nimesulide - Moligand™, 10mM in DMSO , Inhibitor of B⁰AT1;Inhibitor of COX-1;Inhibitor of COX-2, CAS No.51803-78-2, Inhibitor of B⁰AT1;Inhibitor of COX-1;Inhibitor of COX-2

CAS: 51803-78-2 Cat. No.: N407977 Peso molecular: 308.31 Número EC: 257-431-4

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

N-​(4-​nitro-​2-​phenoxyphenyl)​-methanesulfonamide

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Nimesulide is a relativelyCOX-2selective inhibitor withIC50of 26 μM.
In vitro

In vivo

Cell Data

cell lines：HepG2 cells

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

N-​(4-​nitro-​2-​phenoxyphenyl)​-methanesulfonamide

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Nimesulide is a relatively COX-2 selective inhibitor with IC50 of 26 μM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of B⁰AT1;Inhibitor of COX-1;Inhibitor of COX-2

Nombres e identificadores

• Isómeros SMILES: CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=CC=C2
• WGK Alemania: 3
• RTECS: PB0970000
• Peso molecular: 308.31
• Reaxy-Rn: 2421175
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2421175&ln=

Objetivos asociados (humanos)

SLC6A19 Tchem Sodium-dependent neutral amino acid transporter B(0)AT1 (1 Activities)

Discover Target: SLC6A19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS1 Tclin Prostaglandin G/H synthase 1 (1 Activities)

Discover Target: PTGS1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PTGS2 Tclin Prostaglandin G/H synthase 2 (8 Activities)

Discover Target: PTGS2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 66 mg/mL (198.11 mM); Ethanol: -1 mg/mL
• Punto de fusión (°C): 150 °C

Referencias

1. Rongzheng Liu, Xin Wang, Na Fan, Hang Song, Pingping Ma, Chang Li, Jing Li, Jin Sun.  (2021)  Superiority of Chiral-handed mesoporous silica nanoparticles in delivering Nimesulide.  Materials Science and Engineering B-Advanced Functional Solid-State Materials,      [PMID:] [10.1016/j.mseb.2021.115161]

2. Wei Liu, Jiabin Zhou, Ying Zhou, Dan Liu.  (2021)  Peroxymonosulfate-assisted g-C3N4@Bi2MoO6 photocatalytic system for degradation of nimesulide through phenyl ether bond cleavage under visible light irradiation.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2020.118288]

3. Zhong-Xia Wang, Xing Jin, Wen-Juan Wang, Fen-Ying Kong, Jing Zhu, Heng-Ye Li, Yu-Jie Ding, Wei Wang.  (2020)  Green synthesis of a deep-ultraviolet carbonized nanoprobe for ratiometric fluorescent detection of feroxacin and enrofloxacin in food and serum samples.  ANALYST,  146  (3): (874-881).  [PMID:33241796] [10.1039/D0AN02114H]

4. Zhongxia WANG, Yuanfei GAO, Wenjuan WANG, Fenying KONG, Hengye LI, Dahe FAN, Wei WANG.  (2020)  On-off Fluorescent Switching of Excitation-independent Near-ultraviolet Emission Carbon Nanobelts for Ultrasensitive Detection Nimesulide in Pharmaceutical Tablet.  ANALYTICAL SCIENCES,  36  (11): (1379-1385).  [PMID:32655105] [10.2116/analsci.20P181]

5. Ying Zhang, Xie-an Yu, Yiting Hu, Xuefei Bai, Ran Zhang, Mi Lu, Jianhui Sun, Jiangwei Tian, Bo-Yang Yu.  (2020)  A polydopamine-polyethyleneimine/quantum dot sensor for instantaneous readout of cell surface charge to reflect cell states.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2020.128696]

6. Zhongjuan Wang, Li-chao Nengzi, Xinyi Zhang, Zhuanjun Zhao, Xiuwen Cheng.  (2019)  Novel NiCo2S4/CS membranes as efficient catalysts for activating persulfate and its high activity for degradation of nimesulide.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2019.122517]