Norfloxacin hydrochloride - ≥98% , CAS No.68077-27-0

CAS: 68077-27-0 Cat. No.: N304360 Peso molecular: 355.79

GRADE & PURITY ≥98%

Synonyms

JJWDELPVPRCLQN-UHFFFAOYSA-N | Norfloxacinhydrochloride | NORFLOXACIN MONOHYDROCHLORIDE | 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride | Norfloxacinehydrochloride | UNII-7O3ULA741Z | SCHEMBL3147077 | MFCD01075766 | NORFL

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

Norfloxacin hydrochloride (MK-0366 hydrochloride) is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria, which functions by inhibiting DNA gyrase.

Specifications

Sinónimos

JJWDELPVPRCLQN-UHFFFAOYSA-N | Norfloxacinhydrochloride | NORFLOXACIN MONOHYDROCHLORIDE | 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride | Norfloxacinehydrochloride | UNII-7O3ULA741Z | SCHEMBL3147077 | MFCD01075766 | NORFL

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O.Cl
• IUPAC Name: 1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid;hydrochloride
• InChIKey: JJWDELPVPRCLQN-UHFFFAOYSA-N
• INCHI: 1S/C16H18FN3O3.ClH/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20;/h7-9,18H,2-6H2,1H3,(H,22,23);1H
• Isómeros SMILES: CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O.Cl
• CAS alternativo: 70458-96-7
• Peso molecular: 355.79
• Reaxy-Rn: 5686388
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5686388&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Quinolines and derivatives
      • Subclass Quinoline carboxylic acids

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Quinolines and derivatives
• Subclass: Quinoline carboxylic acids
• Intermediate Tree Nodes: Not available
• Direct Parent: Quinoline carboxylic acids
• Alternative Parents: N-arylpiperazines Fluoroquinolones Aminoquinolines and derivatives Hydroquinolones Haloquinolines Hydroquinolines Pyridinecarboxylic acids Dialkylarylamines Aryl fluorides Benzenoids Vinylogous amides Heteroaromatic compounds Amino acids Dialkylamines Carboxylic acids Azacyclic compounds Hydrochlorides Organic oxides Organofluorides Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Quinoline-3-carboxylic acid - Fluoroquinolone - N-arylpiperazine - Aminoquinoline - Haloquinoline - Dihydroquinolone - Dihydroquinoline - Pyridine carboxylic acid - Pyridine carboxylic acid or derivatives - Tertiary aliphatic/aromatic amine - Dialkylarylamine - Benzenoid - Aryl fluoride - Aryl halide - Pyridine - 1,4-diazinane - Piperazine - Vinylogous amide - Heteroaromatic compound - Amino acid or derivatives - Tertiary amine - Amino acid - Secondary amine - Azacycle - Carboxylic acid derivative - Carboxylic acid - Secondary aliphatic amine - Organic oxygen compound - Hydrocarbon derivative - Hydrochloride - Organic nitrogen compound - Amine - Organic oxide - Organooxygen compound - Organohalogen compound - Organofluoride - Organonitrogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as quinoline carboxylic acids. These are quinolines in which the quinoline ring system is substituted by a carboxyl group at one or more positions.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Pseudomonas aeruginosa (123386 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Peso molecular: 355.790 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 355.11 Da
• Monoisotopic Mass: 355.11 Da
• Topological Polar Surface Area: 72.900 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 519.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Referencias

1. Jian-Rong Li, Lei Xu, Ming-Lai Fu, Huachun Lan.  (2017)  Can adsorbent of layered chalcogenide be regenerated? A case study of norfloxacin adsorbed by layered chalcogenide in water.  COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,      [PMID:] [10.1016/j.colsurfa.2017.10.029]

2. Xueying Yang, Xiangdong Zhang, Jiaqi Wang, Jian Zhang, Haina Bai.  (2024)  Efficient and easy-to-recover immobilized heterogeneous catalyst CuSF/ZIF-67 activates peroxymonosulfate to remove refractory antibiotics.  PROCESS SAFETY AND ENVIRONMENTAL PROTECTION,      [PMID:] [10.1016/j.psep.2024.10.098]

3. Shizong Wang, Jianlong Wang, Bo Lai.  (2025)  Support-modulated coordination environments direct divergent PMS activation pathways in Co single-atom catalysts.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2025.125898]

4. Tao Peng, Zhanwei Liang, Jinxue Zhao, Jihao Si, Jie Xie, Xinhua Dai, Lidong Wu.  (2025)  Terbium (III) and adenosine monophosphate coordinated hydrogel for fluoroquinolones sensing by combining machine learning.  FOOD CHEMISTRY,      [PMID:40907184] [10.1016/j.foodchem.2025.146115]

5. Yanjiao Song, Xiuling Song, Xiaoli Liu, Ling Jiang, Lihong Chai.  (2026)  Metagenomics and targeted metabolomics uncover concomitant gut microbiota dysbiosis and bile acid metabolism alteration in norfloxacin-exposed Bufo gargarizans tadpoles.  AQUATIC TOXICOLOGY,      [PMID:41638014] [10.1016/j.aquatox.2026.107742]