NSC-370284 - ≥96% , CAS No.116409-29-1

CAS: 116409-29-1 Cat. No.: N646601 Peso molecular: 387.43 PubChem CID: 340208

COA

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NSC-370284 - ≥96% CAS No(116409-29-1) by Aladdin Scientific

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Disponible para pedir

GRADE & PURITY ≥96%

Synonyms

NCI60_003410 | AKOS024282084 | 6-[1-pyrrolidinyl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol | 6-(1-Pyrrolidinyl(3,4,5-trimethoxyphenyl)methyl)-1,3-benzodioxol-5-ol | 6-[(3,5-Trimethoxyphenyl)-1-pyrrolidinylmethyl]-1,3-benzodioxol-5-ol | {6-[(3,4

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Size

Estado

Price

Qty

5mg

N646601-5mg

8-12 wks(?)

160,90US$

10mg

N646601-10mg

8-12 wks(?)

300,90US$

25mg

N646601-25mg

8-12 wks(?)

640,90US$

50mg

N646601-50mg

8-12 wks(?)

1.080,90US$

100mg

N646601-100mg

8-12 wks(?)

1.880,90US$

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Descripción general Specifications Nombres e identificadores Documentation Advanced Data Taxonomic Classification Estructura 3D Objetivos asociados (humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Calculadoras de soluciones Reseñas

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Why this grade

≥96% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

NSC-370284 is a selective inhibitor of ten-eleven translocation 1 ( TET1 ) and 5-hydroxymethylcytosine ( 5hmC ). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5

In Vitro

NSC-370284 (0-500 nM; 24 h or 48 h) inhibits the viability of MONOMAC-6, THP-1, KOCL-48 and KASUMI-1 acute myeloid leukemia (AML) cells via targeting STAT3/5. NSC-370284 significantly down-regulates the level of TET1 transcription. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: AML cell lines including MONOMAC-6, THP-1, KOCL-48, and KASUMI-1. Concentration: 0, 25, 50, 200 or 500 nM. Incubation Time: 24 h or 48 h. Result: Showed inhibitory for AML cells viability and TET1 transcription.

In Vivo

NSC-370284 (2.5 mg/kg; i.p., once daily for 10 days) improves the pathological morphologies in peripheral blood (PB), bone marrow (BM), spleen, and liver tissues in MLL-AF9 acute myeloid leukemia (AML) mice model . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BL/6 (CD45.2) and B6.SJL (CD45.1) mice . Dosage: 2.5 mg/kg. Administration: Intraperitoneal injection, once daily, for 10 days. Result: Significantly inhibited MLL-AF9 induced AML in secondary bone marrow transplantation (BMT) recipient mice.

Form:Solid

IC50& Target:STAT3 STAT5 TET1

Specifications

Sinónimos

NCI60_003410 | AKOS024282084 | 6-[1-pyrrolidinyl-(3, 4, 5-trimethoxyphenyl)methyl]-1, 3-benzodioxol-5-ol | 6-(1-Pyrrolidinyl(3, 4, 5-trimethoxyphenyl)methyl)-1, 3-benzodioxol-5-ol | 6-[(3, 5-Trimethoxyphenyl)-1-pyrrolidinylmethyl]-1, 3-benzodioxol-5-ol | {6-[(3, 4

Especificaciones y pureza

≥96%

Mecanismos bioquímicos y fisiológicos

NSC-370284 is a selective inhibitor of ten-eleven translocation 1 ( TET1 ) and 5-hydroxymethylcytosine ( 5hmC ). NSC-370284 significantly inhibits the level of TET1 expression via targets STAT3/5.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥96%

Nombres e identificadores

Sonrisas canónicas	COC1=CC(=CC(=C1OC)OC)C(C2=CC3=C(C=C2O)OCO3)N4CCCC4
IUPAC Name	6-[pyrrolidin-1-yl-(3,4,5-trimethoxyphenyl)methyl]-1,3-benzodioxol-5-ol
InChIKey	QCXGNLZKUHBIHD-UHFFFAOYSA-N
INCHI	1S/C21H25NO6/c1-24-18-8-13(9-19(25-2)21(18)26-3)20(22-6-4-5-7-22)14-10-16-17(11-15(14)23)28-12-27-16/h8-11,20,23H,4-7,12H2,1-3H3
Isómeros SMILES	COC1=CC(=CC(=C1OC)OC)C(C2=CC3=C(C=C2O)OCO3)N4CCCC4
CAS alternativo	116409-29-1
PubChem CID	340208
Número NSC	370284
Peso molecular	387.43

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Clase Benzodioxoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Clase	Benzodioxoles
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Benzodioxoles
Alternative Parents	Phenoxy compounds Methoxybenzenes Anisoles Aralkylamines Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids N-alkylpyrrolidines Trialkylamines Oxacyclic compounds Azacyclic compounds Acetals Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Benzodioxole - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Alkyl aryl ether - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Monocyclic benzene moiety - Benzenoid - N-alkylpyrrolidine - Pyrrolidine - Tertiary amine - Tertiary aliphatic amine - Azacycle - Oxacycle - Ether - Acetal - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organopnictogen compound - Organic oxygen compound - Amine - Organic nitrogen compound - Aromatic heteropolycyclic compound
Descripción	This compound belongs to the class of organic compounds known as benzodioxoles. These are organic compounds containing a benzene ring fused to either isomers of dioxole. Dioxole is a five-membered unsaturated ring of two oxygen atoms and three carbon atoms.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estructura 3D

Objetivos asociados (humanos)

P4HB Tchem Protein disulfide-isomerase (1 Activities)

Discover Target: P4HB

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

A498 (42825 Activities)

Solubilidad	DMSO : 100 mg/mL (258.11 mM; Need ultrasonic)
Peso molecular	387.400 g/mol
XLogP3	3.300
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	6
Exact Mass	387.168 Da
Monoisotopic Mass	387.168 Da
Topological Polar Surface Area	69.600 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	487.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

NSC-370284 - ≥96% , CAS No.116409-29-1

Why this grade

Storage & shipping

Quality documents

Literature proof

Descripción general

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reseñas de cliente

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