≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
NSC228155 is an activator ofEGFR. It binds to the sEGFR dimerization domain II and modulates EGFR tyrosine phosphorylation.
Targets
EGFR ; KIX-KID interaction ; 0.36 μM
In vitro
NSC 228155 promotes transactivation of several RTKs, including ErbB2 and ErbB3, Insulin R and IGF-1 R receptors in the cells. It stimulates dimerization of sEGFR domain II. NSC 228155 can rapidly move across cell membranes and disperse within both cytoplasmic and nuclear compartments. It rapidly generates hydrogen peroxide within cells. NSC 228155 is also a potent inhibitor of KIX-KID interaction(IC50 = 0.36 μM), but it is not particularly selective against CREB-mediated gene transcription in HEK 293T cells.
Cell Research(from reference)
Cell lines：MDA MB468 cells
Concentrations：100\u2005μM
Incubation Time：15 min
| ALogP | 1.957 |
|---|---|
| hba_count | 3 |
| Enlace rotable | 3 |
| Pubchem Sid | 504758435 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504758435 |
| Sonrisas canónicas | C1=CC=[N+](C(=C1)SC2=CC=C(C3=NON=C23)[N+](=O)[O-])[O-] |
| IUPAC Name | 7-nitro-4-(1-oxidopyridin-1-ium-2-yl)sulfanyl-2,1,3-benzoxadiazole |
| InChIKey | ICCFXXDUYSPKOL-UHFFFAOYSA-N |
| INCHI | 1S/C11H6N4O4S/c16-14-6-2-1-3-9(14)20-8-5-4-7(15(17)18)10-11(8)13-19-12-10/h1-6H |
| Isómeros SMILES | C1=CC=[N+](C(=C1)SC2=CC=C(C3=NON=C23)[N+](=O)[O-])[O-] |
| Peso molecular | 290.25 |
| Reaxy-Rn | 19528685 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=19528685&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organosulfur compounds |
| Clase | Thioethers |
| Subclass | Aryl thioethers |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Diarylthioethers |
| Alternative Parents | Benzoxadiazoles Thiophenol ethers Nitroaromatic compounds Pyridinium derivatives Heteroaromatic compounds Furazans Sulfenyl compounds Propargyl-type 1,3-dipolar organic compounds Organic oxoazanium compounds Azacyclic compounds Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Diarylthioether - Benzoxadiazole - Nitroaromatic compound - Thiophenol ether - Pyridine - Pyridinium - Benzenoid - Azole - Furazan - Oxadiazole - Heteroaromatic compound - C-nitro compound - Organic nitro compound - Organic oxoazanium - Azacycle - Organoheterocyclic compound - Organic 1,3-dipolar compound - Sulfenyl compound - Propargyl-type 1,3-dipolar organic compound - Allyl-type 1,3-dipolar organic compound - Hydrocarbon derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Organonitrogen compound - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as diarylthioethers. These are organosulfur compounds containing a thioether group that is substituted by two aryl groups. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 K2222628 | Certificate of Analysis | Jun 09, 2026 | N413968 |
| K2222629 | Certificate of Analysis | Jun 09, 2026 | N413968 |
| K2222630 | Certificate of Analysis | Jun 09, 2026 | N413968 |
| K2222632 | Certificate of Analysis | Jun 09, 2026 | N413968 |
| K2222634 | Certificate of Analysis | Jun 09, 2026 | N413968 |
| L2420165 | Certificate of Analysis | Jan 03, 2025 | N413968 |
| Solubilidad | Solubility (25°C) In vitro DMSO: 58 mg/mL (199.82 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| DMSO (mg/ml) Solubilidad máxima | 15 |
| DMSO (mM) Solubilidad máxima | 51.67958656 |
| Agua (mg/ml) Solubilidad máxima | ＜1 |
| Peso molecular | 290.260 g/mol |
| XLogP3 | 1.300 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 2 |
| Exact Mass | 290.011 Da |
| Monoisotopic Mass | 290.011 Da |
| Topological Polar Surface Area | 136.000 Ų |
| Heavy Atom Count | 20 |
| Formal Charge | 0 |
| Complexity | 369.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
