NSC59984 - ≥98% , CAS No.803647-40-7
Disponible
SKU
N413909
p53 Activators
Information
NSC59984 NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation.
Targets
p53
In vitro
NSC59984 specifically restores p53 pathway signaling and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. NSC59984 also induces cell death in a panel of cancer cell lines bearing different p53 mutations with little or no genotoxicity in normal cells.
In vivo
In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner.
Cell Research(from reference)
Cell lines：SW480, DLD-1, HCT116, p53- HCT116, MRC5, Hop92, RXF393 and Wi38 cells
Concentrations：~100 μM
Incubation Time：72 h
Más Información
| CAS | 803647-40-7 |
|---|---|
| Sinónimos | (E)-1-(4-methylpiperazin-1-yl)-3-(5-nitrofuran-2-yl)prop-2-en-1-one | 1-Methyl-4-[3-(5-nitro-2-furanyl)-1-oxo-2-propenyl]-piperazine, MLS000737358 | 1-(4-Methyl-1-piperazinyl)-3-(5-nitro-2-furanyl)-2-propen-1-one | (E)-1-(4-Methylpiperazin-1-yl)-3-(5-nitr |
| Especificaciones y pureza | ≥98% |
| Condiciones de almacenamiento de almacenamiento | Store at -20°C |
| Enviado en | Ice chest + Ice pads |
| Product Description | Information NSC59984 NSC59984 is a p53 pathway activator via induction of mutant p53 protein degradation and p73 activation. Targets p53 In vitro NSC59984 specifically restores p53 pathway signaling and induces p73-dependent cell death in mutant p53-expressing human colorectal cancer cells. NSC59984 also induces cell death in a panel of cancer cell lines bearing different p53 mutations with little or no genotoxicity in normal cells. In vivo In nude mice bearing DLD-1 xenograft tumors, NSC59984 (45 mg/kg, i.p.) significantly represses tumor growth in a p73-dependent manner. Cell Research(from reference) Cell lines：SW480, DLD-1, HCT116, p53- HCT116, MRC5, Hop92, RXF393 and Wi38 cells Concentrations：~100 μM Incubation Time：72 h |
| Pubchem Sid | 504763683 |
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504763683 |
| Solubilidad | Solubility (25°C) In vitro DMSO: 53 mg/mL (199.79 mM); Ethanol: 53 mg/mL (199.79 mM); Water: Insoluble; |
| PubChem CID | 5356520 |
| Fórmula molecular | C12H15N3O4 |
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