NVP DPP 728 - ≥98% , CAS No.247016-69-9

CAS: 247016-69-9 Cat. No.: N274739 Peso molecular: 298.34
Disponible para pedir
GRADE & PURITY ≥98%
Synonyms
NVP-DPP728 | NVP-DPP-728 | NVP-728 | 6-(2-((2-((2S)-2-Cyanopyrrolidin-1-yl)-2-oxo-ethyl)amino)ethylamino)pyridine-3-carbonitrile
Storage
Store at -20°C,Desiccated
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Estado
Price
Qty
1mg
N274739-1mg
1
139,90US$
5mg
N274739-5mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
219,90US$
10mg
N274739-10mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
319,90US$
25mg
N274739-25mg
8-12 wks(?) Production requires sourcing of materials. We appreciate your patience and understanding.
719,90US$
Enter a quantity for the sizes you want to add.
🧪

Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.

NVP-DPP728 is a potent, reversible, nitrile-dependent inhibitor of dipeptidyl peptidase IV (DPP-IV). NVP-DPP728 can inhibit the amide lysozyme activity of human DPP-IV with Ki of 11 nM. NVP-DPP728 inhibits the degradation of glukagon-like peptide-1 (GLP-1), thereby enhancing the release of insulin to glucose intake. NVP-DPP728 can be used in diabetes research

Specifications

Sinónimos
NVP-DPP728 | NVP-DPP-728 | NVP-728 | 6-(2-((2-((2S)-2-Cyanopyrrolidin-1-yl)-2-oxo-ethyl)amino)ethylamino)pyridine-3-carbonitrile
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
Potent, selective, reversible dipeptidyl peptidase-IV (DPP-IV) inhibitor (K i = 11 nM). Antidiabetic agent in vivo .
Condiciones de almacenamiento de almacenamiento
Store at -20°C, Desiccated
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Tipo de acción
INHIBITOR
Nota
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Pureza
≥98%
Nombres e identificadores
Sonrisas canónicasC1CC(N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N
IUPAC Name6-[2-[[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]amino]ethylamino]pyridine-3-carbonitrile
InChIKeyVFFZWMWTUSXDCB-ZDUSSCGKSA-N
INCHI1S/C15H18N6O/c16-8-12-3-4-14(20-10-12)19-6-5-18-11-15(22)21-7-1-2-13(21)9-17/h3-4,10,13,18H,1-2,5-7,11H2,(H,19,20)/t13-/m0/s1
Isómeros SMILES C1C[C@H](N(C1)C(=O)CNCCNC2=NC=C(C=C2)C#N)C#N
CAS alternativo 207556-62-5
Peso molecular 298.34
Reaxy-Rn 14445970
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=14445970&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClaseCarboxylic acids and derivatives
SubclassAmino acids, peptides, and analogues
Intermediate Tree Nodes Amino acids and derivatives - Alpha amino acids and derivatives
Direct ParentAlpha amino acid amides
Alternative Parents N-acylpyrrolidines  3-pyridinecarbonitriles  Aminopyridines and derivatives  Imidolactams  Tertiary carboxylic acid amides  Heteroaromatic compounds  Nitriles  Dialkylamines  Azacyclic compounds  Organic oxides  Hydrocarbon derivatives  Carbonyl compounds  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Alpha-amino acid amide - N-acylpyrrolidine - 3-pyridinecarbonitrile - Aminopyridine - Pyridine - Imidolactam - Heteroaromatic compound - Pyrrolidine - Tertiary carboxylic acid amide - Carboxamide group - Secondary aliphatic amine - Carbonitrile - Nitrile - Azacycle - Secondary amine - Organoheterocyclic compound - Organic oxygen compound - Amine - Organic oxide - Organic nitrogen compound - Organonitrogen compound - Organooxygen compound - Hydrocarbon derivative - Carbonyl group - Cyanide - Aromatic heteromonocyclic compound
DescripciónThis compound belongs to the class of organic compounds known as alpha amino acid amides. These are amide derivatives of alpha amino acids.
External Descriptors Not available
Estructura 3D
Modelo de Estructura Química Interactiva





Objetivos asociados (humanos)
DPP4 Tclin Dipeptidyl peptidase 4 (17 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
DPP7 Tchem Dipeptidyl peptidase II (2000 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
DPP8 Tchem Dipeptidyl peptidase VIII (2139 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Homo sapiens (32628 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Objetivos asociados (no humanos)
DPP4 Dipeptidyl peptidase IV (11 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Hdac6 Histone deacetylase 6 (222 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mus musculus (284745 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Rattus norvegicus (775804 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Monkey (844 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Cynomolgus monkey (4946 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
rep Replicase polyprotein 1ab (378 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mecanismos de acción
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

5 results found

Lot NumberCertificate TypeFechaArticulo
H2416187Certificate of AnalysisAug 08, 2024 N274739
H2416189Certificate of AnalysisAug 08, 2024 N274739
H2416190Certificate of AnalysisAug 08, 2024 N274739
H2416191Certificate of AnalysisAug 08, 2024 N274739
H2416192Certificate of AnalysisAug 08, 2024 N274739
Propiedades químicas y físicas
Solubilidad≥ 17.75mg/mL in DMSO with gentle warming, ≥ 81 mg/mL in EtOH, ≥ 82 mg/mL in Water
Peso molecular298.340 g/mol
XLogP30.300
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass298.154 Da
Monoisotopic Mass298.154 Da
Topological Polar Surface Area105.000 Ų
Heavy Atom Count22
Formal Charge0
Complexity475.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Calculadoras de soluciones
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