O-Phospho-L-tyrosine - ≥95%(HPLC) , CAS No.21820-51-9

CAS: 21820-51-9 Cat. No.: O132562 Peso molecular: 261.17 Número EC: 891-585-9

GRADE & PURITY ≥95%(HPLC)

Synonyms

(S)-2-amino-3-(4-(phosphonooxy)phenyl)propanoic acid | H-Tyr(PO)-OH | AS-19190 | CHEBI:37788 | O(4)-phosphono-L-tyrosine | DTXSID00176234 | H-Tyr(PO3H2)-OH | Tyrosine, phosphate (6CI) | AKOS015894042 | J-014304 | P0959 | L-Tyrosine, dihydrogen phosphate (

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

(S)-2-amino-3-(4-(phosphonooxy)phenyl)propanoic acid | H-Tyr(PO)-OH | AS-19190 | CHEBI:37788 | O(4)-phosphono-L-tyrosine | DTXSID00176234 | H-Tyr(PO3H2)-OH | Tyrosine, phosphate (6CI) | AKOS015894042 | J-014304 | P0959 | L-Tyrosine, dihydrogen phosphate (

Especificaciones y pureza

≥95%(HPLC)

Mecanismos bioquímicos y fisiológicos

Useful reagent in the study of tyrosine-phosphorylation, which has been linked with the malignant transformation of cells by some RNA tumour viruses.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥95%(HPLC)

Nombres e identificadores

• Pubchem Sid: 504753417
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504753417
• Sonrisas canónicas: C1=CC(=CC=C1CC(C(=O)O)N)OP(=O)(O)O
• IUPAC Name: (2S)-2-amino-3-(4-phosphonooxyphenyl)propanoic acid
• InChIKey: DCWXELXMIBXGTH-QMMMGPOBSA-N
• INCHI: 1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1
• Isómeros SMILES: C1=CC(=CC=C1C[C@@H](C(=O)O)N)OP(=O)(O)O
• Peso molecular: 261.17
• Reaxy-Rn: 4260804
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4260804&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Phenylalanine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Phenylalanine and derivatives
• Alternative Parents: Phenylpropanoic acids Phenyl phosphates L-alpha-amino acids Amphetamines and derivatives Phenoxy compounds Aralkylamines Amino acids Monocarboxylic acids and derivatives Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Phenylalanine or derivatives - 3-phenylpropanoic-acid - Phenyl phosphate - Alpha-amino acid - L-alpha-amino acid - Amphetamine or derivatives - Aryl phosphomonoester - Aryl phosphate - Phenoxy compound - Aralkylamine - Phosphoric acid ester - Monocyclic benzene moiety - Organic phosphoric acid derivative - Benzenoid - Amino acid - Monocarboxylic acid or derivatives - Carboxylic acid - Organic nitrogen compound - Organooxygen compound - Organonitrogen compound - Primary amine - Hydrocarbon derivative - Primary aliphatic amine - Organic oxide - Carbonyl group - Organopnictogen compound - Organic oxygen compound - Amine - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as phenylalanine and derivatives. These are compounds containing phenylalanine or a derivative thereof resulting from reaction of phenylalanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: non-proteinogenic L-alpha-amino acid - L-tyrosine derivative - O(4)-phosphotyrosine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

LCK Tclin Tyrosine-protein kinase LCK (9212 Activities)

Discover Target: LCK

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SRC Tclin Tyrosine-protein kinase SRC (10310 Activities)

Discover Target: SRC

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PTPN11 Tchem Protein-tyrosine phosphatase 2C (2297 Activities)

Discover Target: PTPN11

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Grb2 Growth factor receptor-bound protein 2 (49 Activities)

Discover Target: Grb2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: heat sensitive
• Rotación específica [α]: -6° (C=1,2mol/L HCl)
• Peso molecular: 261.170 g/mol
• XLogP3: -2.800
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 261.04 Da
• Monoisotopic Mass: 261.04 Da
• Topological Polar Surface Area: 130.000 Ų
• Heavy Atom Count: 17
• Formal Charge: 0
• Complexity: 309.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Yuyan Guo, Tao Gao, Fang Fang, Shuang Sun, Dayu Yang, Yongji Li, Shaowa Lv.  (2021)  A novel polymer micelle as a targeted drug delivery system for 10-hydroxycamptothecin with high drug-loading properties and anti-tumor efficacy.  BIOPHYSICAL CHEMISTRY,      [PMID:34547633] [10.1016/j.bpc.2021.106679]

2. Fen-Ying Kong, Hui-Yu Zou, Meng Xiong, Jia-Dong Zhang, Wei Wang, Wei-Wei Zhao.  (2020)  3D NiO nanoflakes/carbon fiber meshwork: Facile preparation and utilization as general platform for photocathodic bioanalysis.  ANALYTICA CHIMICA ACTA,      [PMID:33384115] [10.1016/j.aca.2020.11.046]

3. Xia Cheng, Yuying Chai, Jian Xu, Lin Wang, Fangdi Wei, Guanhong Xu, Yong Sun, Qin Hu, Yao Cen.  (2020)  Enzyme cascade reaction-based ratiometric fluorescence probe for visual monitoring the activity of alkaline phosphatase.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2020.127765]