ODN 1668 - ≥99% , CAS No.1186063-66-0

CAS: 1186063-66-0 Cat. No.: O648744 Peso molecular: 6364.10

GRADE & PURITY ≥99%

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 is an immunostimulatory sequence and can be used as vaccine adjuvant. Sequence: 5'-tccatgacgttcctgatgct-3’

In Vitro

ODN 1668 induces TNF-α secretion and promotes polyclonal B cell activation. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ODN 1668 (10 nmol) stimulates responses to protein antigen . ODN 1668 (1 or 5 mg/kg; i.p. or s.c.; once) causes moderate fever and anorexia in rats. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57BW6 mice Dosage: 10 nmol Administration: 300 μg OVA (ovalbumin) in PBS or liposomes containing OVA were injected with or without 10nmol ODN in the hind footpads of C57BW6 mice. A boost of the same\ninoculum was given at 2 weeks, and 1 week later blood was taken for serum antibody titering. Result: Strongly potentiated the antibody response and induced class switching toward IgG2a and IgG2b. Showed B cell blast formation and a more than twofold increase in B7.2 (CD86) and IL-2 receptor-α (CD25) surface expression. Animal Model: Male Wistar rats with body weights in the range of 175–200 gDosage: 1 mg/kg or 5 mg/kg Administration: Intraperitoneal and subcutaneous injection, once Result: Caused moderate fever and anorexia. Induced a significant increase of IL-6. Increased expression of inflammatory genes and activated inflammatory transcription factors.

Form:Solid

IC50& Target:TLR9

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

ODN 1668, a class B CpG ODN (oligodeoxynucleotide), is a TLR-9 agonist. ODN 1668 is an immunostimulatory sequence and can be used as vaccine adjuvant. Sequence: 5'-tccatgacgttcctgatgct-3’.

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥99%

Nombres e identificadores

• Peso molecular: 6364.10

Propiedades químicas y físicas

• Solubilidad: H2O : ≥ 20 mg/mL (3.14 mM)