Okadaic Acid, Potassium Salt - ≥98% , CAS No.155751-72-7

CAS: 155751-72-7 Cat. No.: O338097 Peso molecular: 843.1 Número EC: 621-137-8 PubChem CID: 44134868

GRADE & PURITY ≥98%

Synonyms

2-hydroxy-3-[11-hydroxy-2-[4-[4-hydroxy-2-[1-hydroxy-3-(3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylp

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Descripción general

Okadaic Acid, Potassium Salt is a water-soluble analog of Okadaic Acid, isolated from cultured|Prorocentrum concavum|. The salt form is generated in aqueous potassium hydroxide methanol solution. The compound is a potent inhibitor of serine/threonine-specific protein phosphatases PP1, PP2A, 5534, PP2C and endogenous phosphatase smooth muscle myosin at IC|50|of 10-15 nM, 0.1 nM, 5 μM, >10 μM and 15-70 nM respectively. This inhibition action has been used to stimulate the activity of glucose transport and has been observed to block insulin's stimulation of glucose transport by inhibiting IRS-1 phosphorylation. Okadaic Acid, Potassium Salt has been used as a response modifier in the study of large granular lymphocyte and T-cell biochemistry. In addition to inhibitive activities it is a tumor promoter and has been used to study nitric oxide metabolism, apoptosis, cell cycle and calcium signaling.

Specifications

Sinónimos

2-hydroxy-3-[11-hydroxy-2-[4-[4-hydroxy-2-[1-hydroxy-3-(3-methyl-1, 7-dioxaspiro[5.5]undecan-2-yl)butyl]-3-methylidenespiro[4a, 7, 8, 8a-tetrahydro-4H-pyrano[3, 2-b]pyran-6, 5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1, 7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylp

Especificaciones y pureza

≥98%

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)[O-])O)O)C)O)O.[K+]
• IUPAC Name: potassium;2-hydroxy-3-[11-hydroxy-2-[4-[4-hydroxy-2-[1-hydroxy-3-(3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl)butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-methylpropanoate
• InChIKey: UXRQUXBFVICHQJ-UHFFFAOYSA-M
• INCHI: 1S/C44H68O13.K/c1-25-21-34(55-44(23-25)35(46)12-11-31(54-44)24-41(6,50)40(48)49)26(2)9-10-30-14-18-43(53-30)19-15-33-39(57-43)36(47)29(5)38(52-33)32(45)22-28(4)37-27(3)13-17-42(56-37)16-7-8-20-51-42;/h9-10,23,26-28,30-39,45-47,50H,5,7-8,11-22,24H2,1-4,6H3,(H,48,49);/q;+1/p-1
• Isómeros SMILES: CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)[O-])O)O)C)O)O.[K+]
• PubChem CID: 44134868
• Peso molecular: 843.1

Propiedades químicas y físicas

• Solubilidad: Soluble in water, ethanol, methanol, acetone, ethyl acetate, chloroform
• Sensibilidad: light sensitive