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Olamkicept , CAS No.1702282-14-1
Disponible para pedir
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Olamkicept (FE 999301) is a selective inhibitor of the soluble interleukin 6 ( sIL-6R )/ IL-6 complex. Olamkicept is a soluble gp130-Fc-fusion-protein and anti-inflammatory agent
In Vitro
Olamkicept (10 µg/mL, 60 min) inhibits IL-6 trans-signaling mediated STAT3 activation in HRECs . Olamkicept (10 µg/mL, 60 min) inhibits IL-6 trans-signaling induced increase in H 2 O 2 levels in HRECs . Olamkicept (10 µg/mL, 60 min) inhibits IL-6 trans-signaling induced apoptosis in HRECs . Olamkicept (0-1 µg/mL) inhibits IL-11/recombinant sIL-11R induced proliferation of Ba/F3-gp130 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis Cell Line: Human retinal endothelial cells (HRECs) Concentration: 10 µg/mL Incubation Time: 60 min Result: Inhibited IL-6/sIL-6R induced increase in STAT3 phosphorylation.
In Vivo
Olamkicept (sgp130Fc) (0.01-10 mg/kg, s.c.) increases survival in a cecal ligation and puncture (CLP) sepsis mice model. Olamkicept (0.5 mg/kg, i.p.) suppresses inflammation and increases survival rate in cecum ligation and puncture (CLP)-induced mice with sepsis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Cecal ligation and puncture (CLP) sepsis mice modelDosage: 0.01, 0.1, 1, 10 mg/kg Administration: s.c. Result: Improved survival rate and physical activity.
IC50& Target:sIL-6R/IL-6 Complex
Specifications
Mecanismos bioquímicos y fisiológicos
Olamkicept (FE 999301) is a selective inhibitor of the soluble interleukin 6 ( sIL-6R )/ IL-6 complex. Olamkicept is a soluble gp130-Fc-fusion-protein and anti-inflammatory agent.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Nombres e identificadores
| Sonrisas canónicas | [Olamkicept] |
|---|
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
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