OP-1074 - ≥99% , CAS No.1443752-76-8

CAS: 1443752-76-8 Cat. No.: O650512 Peso molecular: 457.56

GRADE & PURITY ≥99%

Storage

Store at -20°C,Argon charged,Desiccated

Shipped In

Ice chest + Ice pads

Descripción general

OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD) , shows specific antiestrogenic activity for ERα and ERβ , inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC 50 of 1.6 and 3.2 nM, respectively

In Vitro

OP-1074 (0-100 nM; 24 hours) inhibits  MCF-7 cells  and CAMA-1 cells proliferation with IC50 values of 6.3 and 9.2 nM, respectively. OP-1074 (100 nM; 24 hours) destabilizatizes ERα protein expression in MCF-7 and CAMA-1 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: MCF-7 cells, CAMA-1 cells Concentration: 0 nM, 10 nM,100 nM Incubation Time: 24 hours Result: Inhibited breast cancer cell proliferation. Western Blot AnalysisCell Line: MCF-7 cells, CAMA-1 cells Concentration: 100 nM Incubation Time: 24 hours Result: Downregulated ERα protein expression.

Form:Solid

IC50& Target:ERα ERβ

Specifications

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD) , shows specific antiestrogenic activity for ERα and ERβ , inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC 50 of 1.6 and 3.2u2009nM, respectively.

Condiciones de almacenamiento de almacenamiento

Store at -20°C, Argon charged, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

DEGRADER

Pureza

≥99%

Nombres e identificadores

• Peso molecular: 457.56

Propiedades químicas y físicas

• Solubilidad: DMSO : 100 mg/mL (218.55 mM; Need ultrasonic)