Osthole - Moligand™, 10mM in DMSO , Channel blocker of TRPV3, CAS No.484-12-8, Channel blocker of TRPV3

CAS: 484-12-8 Cat. No.: O408868 Peso molecular: 244.29 Número EC: 610-421-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Osthol | 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-buten-1-yl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.
In vitro

Osthol is an O-methylated coumarin which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens. Osthol inhibites platelet aggregation and ATP release induced by ADP, arachidonic acid, PAF, collagen, ionophore A23187 and thrombin in washed rabbit platelets. Osthole mediates cell differentiation through bone morphogenetic protein-2/p38 and extracellular signal-regulated kinase 1/2 pathway in human osteoblast cells and may be a promising agent for treating osteoporosis. Osthole also suppresses the secretion of hepatitis B virus in cell culture by increasing the glycosylation of HBsAg.

In vivo

LD50: Rats >125mg/kg (i.v.); Rabbits >35mg/kg (i.v.); Dogs >150mg/kg (i.v.).
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Osthol | 2H-1-Benzopyran-2-one, 7-methoxy-8-(3-methyl-2-buten-1-yl)-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Osthol is an O-methylated coumarin, which is found in the plants such as Cnidium monnieri, Angelica archangelica and Angelica pubescens.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

CHANNEL BLOCKER

Mecanismo de acción

Channel blocker of TRPV3

Nombres e identificadores

• Isómeros SMILES: CC(=CCC1=C(C=CC2=C1OC(=O)C=C2)OC)C
• WGK Alemania: 1
• RTECS: GN7700000
• CAS alternativo: 484-12-8
• Número NSC: 31868
• Términos de entrada MeSH: 7-methoxy-8-(3-methylpent-2-enyl)coumarin;osthol;osthole
• Peso molecular: 244.29
• Reaxy-Rn: 1288399
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1288399&ln=

Objetivos asociados (humanos)

TRPV3 Tchem Transient receptor potential cation channel subfamily V member 3 (1 Activities)

Discover Target: TRPV3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de ebullición (°C): 145～150°C
• Punto de fusión (°C): 83-84°C

Referencias

1. Duo Lai, Delin Wang, Xuehua Shao, Jian Qin, Qingli Zhuang, Hanhong Xu, Weiqiang Xiao.  (2023)  Comparative physiological and transcriptome analysis provide insights into the inhibitory effect of osthole on Penicillium choerospondiatis.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:38225092] [10.1016/j.pestbp.2023.105749]

2. Huang Hui, Xue Jie, Xie Mei-Lin, Xie Tao.  (2023)  Osthole inhibits GSK-3β/AMPK/mTOR pathway-controlled glycolysis and increases radiosensitivity of subcutaneous transplanted hepatocellular carcinoma in nude mice.  STRAHLENTHERAPIE UND ONKOLOGIE,      [PMID:37963994] [10.1007/s00066-023-02173-8]

3. Ke Hu, Rongyu Li, Feixu Mo, Yi Ding, Aiai Zhou, Xue Guo, Ruotong Li, Min Li, Minggui Ou, Ming Li.  (2023)  Natural product osthole can significantly disrupt cell wall integrity and dynamic balance of Fusarium oxysporum.  PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY,      [PMID:37945232] [10.1016/j.pestbp.2023.105623]

4. Chuanyi Gu, Chunru Wang, Wenjie Ma, Yunli Gao, Junyao Li, Qing Jin, Xiaochen Wu.  (2023)  Drug-Loaded Konjac Glucomannan/Metal–Organic Framework Composite Hydrogels as Antibacterial and Anti-Inflammatory Cell Scaffolds.  ACS Applied Materials & Interfaces,      [PMID:37632730] [10.1021/acsami.3c06996]

5. Weizhen Wang, Linan He, Zhuzhu Zhang, Wenzhi Li, Jia Chen, Tingting Chen, Youhua Long.  (2023)  Activity of the botanical compound thymol against kiwifruit rot caused by Fusarium tricinctum and the underlying mechanisms.  PEST MANAGEMENT SCIENCE,      [PMID:36864770] [10.1002/ps.7431]

6. Ruige Yang, Zhiyan Liu, Meiyue Han, Liping Cui, Yong Guo.  (2022)  Preparation and Biological Evaluation of Novel Osthole-Derived N-Benzoylthioureas as Insecticide Candidates.  JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,      [PMID:36508570] [10.1021/acs.jafc.2c06558]

7. Huang Hui, Xue Jie, Xie Tao, Xie Mei-Lin.  (2022)  Osthole increases the radiosensitivity of hepatoma cells by inhibiting GSK-3β/AMPK/mTOR pathway-controlled glycolysis.  NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY,  396  (4): (683-692).  [PMID:36445387] [10.1007/s00210-022-02347-8]

8. Kuang Yi, Xia Yunlong, Wang Xing, Rao Qingqing, Yang Shengxiang.  (2022)  Magnetic Surface Molecularly Imprinted Polymer for Selective Adsorption of 4-Hydroxycoumarin.  Frontiers in Chemistry,      [PMID:35464201] [10.3389/fchem.2022.862777]

9. Pan Liuliu, Zhang Xiaodan, Wang Danhan, Huang Min, Huang Qiusui, Duan Ping, Mei Jie.  (2021)  DCLK1 might be a therapeutic target of osthole against cervical cancer.  PHARMAZIE,  76  (10): (503-506).  [PMID:34620279] [10.1691/ph.2021.1641]

10. Yasi Mo, Yong Wu, Xin Li, Hui Rao, Xianxiang Tian, Danni Wu, Zhenpeng Qiu, Guohua Zheng, Junjie Hu.  (2019)  Osthole delays hepatocarcinogenesis in mice by suppressing AKT/FASN axis and ERK phosphorylation.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:31712058] [10.1016/j.ejphar.2019.172788]

11. Xiaohong Xu, Vinothakumar Rajamanicham, Sujing Xu, Zhoudi Liu, Tao Yan, Guang Liang, Guilong Guo, Huiping Zhou, Yi Wang.  (2019)  Schisandrin A inhibits triple negative breast cancer cells by regulating Wnt/ER stress signaling pathway.  BIOMEDICINE & PHARMACOTHERAPY,      [PMID:31048190] [10.1016/j.biopha.2019.108922]

12. Dai Xuanxuan, Yin Changtian, Zhang Yi, Guo Guilong, Zhao Chengguang, Wang Ouchen, Xiang Youqun, Zhang Xiaohua, Liang Guang.  (2018)  Osthole inhibits triple negative breast cancer cells by suppressing STAT3.  JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH,  37  (1): (1-11).  [PMID:30577812] [10.1186/s13046-018-0992-z]

13. Botao Wang, Xin Zheng, Jing Liu, Zhen Zhang, Chongyang Qiu, Lei Yang, Lanqiu Zhang, Qi Zhang, Hongwei Gao, Ximo Wang.  (2018)  Osthole inhibits pancreatic cancer progression by directly exerting negative effects on cancer cells and attenuating tumor-infiltrating M2 macrophages.  JOURNAL OF PHARMACOLOGICAL SCIENCES,      [PMID:30098910] [10.1016/j.jphs.2018.07.007]

14. Yiyi Jin, Jianchang Qian, Xin Ju, Xiaodong Bao, Li Li, Suqing Zheng, Xiong Chen, Zhongxiang Xiao, Xuemei Chen, Weiwei Zhu, Weixin Li, Wencan Wu, Guang Liang.  (2018)  Osthole Protects against Acute Lung Injury by Suppressing NF-κB-Dependent Inflammation.  MEDIATORS OF INFLAMMATION,      [PMID:30057486] [10.1155/2018/4934592]

15. Xu Renguo, Liu Zhen, Hou Jiande, Huang Tao, Yang Ming.  (2018)  Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress.  CELLULAR & MOLECULAR BIOLOGY LETTERS,  23  (1): (1-11).  [PMID:29743895] [10.1186/s11658-018-0086-0]

16. Ting Xu, Zihan Xue, Xinhui Li, Miaomiao Zhang, Ruige Yang, Shangshang Qin, Yong Guo.  (2025)  Development of Membrane-Targeting Osthole Derivatives Containing Pyridinium Quaternary Ammonium Moieties with Potent Anti-Methicillin-Resistant Staphylococcus aureus Properties.  JOURNAL OF MEDICINAL CHEMISTRY,      [PMID:40205941] [10.1021/acs.jmedchem.4c03167]

17. Huifang Liu, Jianmei Yao, Rongxiu Yin, Chiyu Ma, Lulu Li, Wen Yang, Zhiwei Lei.  (2025)  Antifungal mechanism of carvacrol and osthole can disrupt cell structure integrity and interfere with energy metabolism in Neopestalotiopsis ellipsospora.  Frontiers in Sustainable Food Systems,      [PMID:] [10.3389/fsufs.2025.1591966]

18. Hamza Tariq, Peiyu Chen, Gang Wang, Siyuan Xie, Lanning Wang, Jingkun Lv, Fei Wang, Muhammad Saqib Bilal, Abdur Rashid Khan, Nasir Ahmed Rajput, Danyu Shen, Daolong Dou.  (2025)  Trans-2-decenal inhibits Alternaria alternata through disruption of redox homeostasis and membrane integrity.  PEST MANAGEMENT SCIENCE,      [PMID:40948311] [10.1002/ps.70223]

19. Lijun Fang, Wei Wang, Jiazheng Chen, Anju Zuo, Hongmei Gao, Tao Yan, Pengqi Wang, Yujia Lu, Ruijuan Lv, Feng Xu, Yuguo Chen, Linmao Lyu.  (2021)  Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.  Oxidative Medicine and Cellular Longevity,      [PMID:34527170] [10.1155/2021/3309944]

20. Xing-Hua Zhou, Jian Kang, Zhen-Dong Zhong, Yue Cheng.  (2021)  Osthole induces apoptosis of the HT‑29 cells via endoplasmic reticulum stress and autophagy.  Oncology Letters,  22  (4): (1-9).  [PMID:34429766] [10.3892/ol.2021.12987]

21. Jie Mei, Tiejun Wang, Shaojie Zhao, Yan Zhang.  (2021)  Osthole Inhibits Breast Cancer Progression through Upregulating Tumor Suppressor GNG7.  Journal of Oncology,      [PMID:33727922] [10.1155/2021/6610511]

22. Zhangrui Luo, Jiaxing Yu, Jiaohong Li, Xiaomao Wu.  (2026)  Control of Neofusicoccum parvum-induced fruit rot in Rosa roxburghii using osthol: from laboratory efficacy to field application.  PHYSIOLOGICAL AND MOLECULAR PLANT PATHOLOGY,      [PMID:] [10.1016/j.pmpp.2026.103129]