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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items OTX015 - Moligand™, ≥98% , Bromodomain and extra-terminal motif (BET) inhibitor, CAS No.202590-98-5, Bromodomain and extra-terminal motif (BET) inhibitor
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
OTX 015 | OTX-015 | 2-((6S)-4-(4-CHLOROPHENYL)-2,3,9-TRIMETHYL-6H-THIENO(3,2- F)(1,2,4)TRIAZOLO(4,3-A)(1,4)DIAZEPIN-6-YL)- N-(4-HYDROXYPHENYL)ACETAMIDE | CILENGITIDE [USAN] | NSC778747 | NSC-778747 | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays.
Specifications Sinónimos
OTX 015 | OTX-015 | 2-((6S)-4-(4-CHLOROPHENYL)-2, 3, 9-TRIMETHYL-6H-THIENO(3, 2- F)(1, 2, 4)TRIAZOLO(4, 3-A)(1, 4)DIAZEPIN-6-YL)- N-(4-HYDROXYPHENYL)ACETAMIDE | CILENGITIDE [USAN] | NSC778747 | NSC-778747 | 6H-Thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepine-6-
Especificaciones y pureza
Moligand™, ≥98%
Mecanismos bioquímicos y fisiológicos
BET bromodomain inhibitor (IC50values are in the range 92 - 112 nM). Inhibits proliferation and induces apoptosis of leukemia cell linesin vitro. Decreases BRD2, BRD4 and c-MYC protein expression. Orally bioavailable.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Mecanismo de acción
Bromodomain and extra-terminal motif (BET) inhibitor
Propiedades del producto Nombres e identificadores Pubchem Sid 488196446 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488196446 Sonrisas canónicas CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C IUPAC Name 2-[(9S)-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.02,6]trideca-2(6),4,7,10,12-pentaen-9-yl]-N-(4-hydroxyphenyl)acetamide InChIKey GNMUEVRJHCWKTO-FQEVSTJZSA-N INCHI 1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1 Isómeros SMILES CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C Peso molecular 491.99 Reaxy-Rn 31169916 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31169916&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Clase Thienodiazepines Subclass Not available Intermediate Tree Nodes Not available Direct Parent Thienodiazepines Alternative Parents Anilides N-arylamides 1,4-diazepines 1-hydroxy-2-unsubstituted benzenoids Chlorobenzenes Aryl chlorides Triazoles Thiophenes Heteroaromatic compounds Secondary carboxylic acid amides Ketimines Propargyl-type 1,3-dipolar organic compounds Azacyclic compounds Carbonyl compounds Hydrocarbon derivatives Organic oxides Organochlorides Molecular Framework Aromatic heteropolycyclic compounds Substituents Thieno-para-diazepine - Anilide - N-arylamide - Halobenzene - Phenol - Para-diazepine - 1-hydroxy-2-unsubstituted benzenoid - Chlorobenzene - Benzenoid - Aryl chloride - Monocyclic benzene moiety - Aryl halide - 1,2,4-triazole - Thiophene - Heteroaromatic compound - Azole - Carboxamide group - Ketimine - Secondary carboxylic acid amide - Azacycle - Organic 1,3-dipolar compound - Carboxylic acid derivative - Propargyl-type 1,3-dipolar organic compound - Organooxygen compound - Organic oxide - Organic oxygen compound - Carbonyl group - Organic nitrogen compound - Hydrocarbon derivative - Imine - Organonitrogen compound - Organohalogen compound - Organochloride - Aromatic heteropolycyclic compound Descripción This compound belongs to the class of organic compounds known as thienodiazepines. These are heteropolycyclic containing a thiophene ring fused to a diazepine ring. Thiophene is 5-membered ring consisting of four carbon and one sulfur atoms. Diazepine is a 7-membered ring consisting of five carbon and two nitrogen atoms. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solvent:DMSO, Max Conc. mg/mL: 49.2, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 9.84, Max Conc. mM: 20 Sensibilidad Heat Sensitive Punto de fusión (°C) 220 °C Peso molecular 492.000 g/mol XLogP3 4.500 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 4 Exact Mass 491.118 Da Monoisotopic Mass 491.118 Da Topological Polar Surface Area 121.000 Ų Heavy Atom Count 34 Formal Charge 0 Complexity 770.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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