10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 21 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Oxymatrine (Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens with anti-inflammatory, antifibrosis, and antitumor effects, inhibits the iNOS expression and TGF-β/Smad pathway. It is used for the treatment of viral
In vitro
Oxymatrine is a quinolizidine alkaloid extracted from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases (such as colpitis, psoriasis and eczema). Oxymatrine protects mice from fulminant hepatitis induced by GalN/LPS and may block hepatocyte apoptosis and subsequent necrosis through downregulating the production of serum tumor necrosis factor alpha and the expression of Fas and Fas ligand in liver tissue. ) Oxymatrine also shows anti-hepatitis B virus effect in vivo by reducing the contents of HBsAg and HBcAg in transgenic mice liver.
In vivo
LD50: Mice 521mg/kg (i.p.)
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥98%
| Isómeros SMILES | C1C[C@@H]2[C@H]3CCC[N+]4([C@H]3[C@@H](CCC4)CN2C(=O)C1)[O-] |
|---|---|
| Peso molecular | 264.36 |
| Reaxy-Rn | 753307 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=753307&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Punto de fusión (°C) | 206℃ |
|---|
| 1. Yanshi Wang, Shaojie Yang, Shanshan Zhang, Xin Wu. (2020) Oxymatrine Inhibits Proliferation and Migration of Vulvar Squamous Cell Carcinoma Cells via Attenuation of the RAS/RAF/MEK/ERK Pathway. Cancer Management and Research, [PMID:32256113] [10.2147/CMAR.S245696] |
| 2. Wei Zhou, Yikun Liu, Xiaoyan Liao, Zilin Chen. (2019) Capillary electrophoresis-mass spectrometry using robust poly(ether ether ketone) capillary for tolerance to high content of organic solvents. JOURNAL OF CHROMATOGRAPHY A, [PMID:30718059] [10.1016/j.chroma.2019.01.070] |
| 3. Yu-Mei Zhao, Lv-Huan Wang, Si-Fan Luo, Qi-Qin Wang, Ruin Moaddel, Ting-Ting Zhang, Zheng-Jin Jiang. (2018) Magnetic beads-based neuraminidase enzyme microreactor as a drug discovery tool for screening inhibitors from compound libraries and fishing ligands from natural products. JOURNAL OF CHROMATOGRAPHY A, [PMID:30005943] [10.1016/j.chroma.2018.07.031] |
| 4. Juan Zhang, Zilin Chen. (2013) Determination of Matrine and Oxymatrine in Sophora Flavescens by Nonaqueous Capillary Electrophoresis-Electrospray Ionization-Ion Trap-Mass Spectrometry. ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2012.726684] |
| 5. Chen He, Wenjing Wang, Guoli Wei, Yuqing Wang, Yingjie Wei, Jing Wang, Zhenhai Zhang. (2023) Sodium alginate combined with oxymatrine ameliorates CCl4-induced chemical hepatic fibrosis in mice. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:37922569] [10.1016/j.intimp.2023.111144] |
| 6. Fa-Li Zhang, Liu Yang, Wei-Hao He, Ling-Jun Xie, Fei Yang, Ying-Hui Wang, Ai-Guo Huang. (2023) In vivo antibacterial activity of medicinal plant Sophora flavescens against Streptococcus agalactiae infection. JOURNAL OF FISH DISEASES, 46 (9): (977-986). [PMID:37294673] [10.1111/jfd.13818] |
| 7. Shengwei Li, Guangqing Feng, Min Zhang, Xing Zhang, Jihong Lu, Chenyahui Feng, Fangshi Zhu. (2022) Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway. HUMAN & EXPERIMENTAL TOXICOLOGY, [PMID:35290143] [10.1177/09603271221078866] |
| 8. Jin Yinshan, Liu Jiannan, Liu Yadong, Liu Yang, Guo Guiying, Yu Shiliang, An Ruihua. (2020) Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression. Frontiers in Pharmacology, [PMID:32581789] [10.3389/fphar.2020.00808] |
| 9. Haiping Li, Bo Zhang, Fanping Meng, Siyuan Shao, Yufan Xia, Yu Yao. (2024) Adsorption, natural attenuation, and microbial community response of ofloxacin and oxolinic acid in marine sediments. ENVIRONMENTAL POLLUTION, [PMID:38458522] [10.1016/j.envpol.2024.123738] |
| 10. Huifang Li, Yu Yue, Xiao Wang, Dahuan Liu. (2025) An environmentally friendly lithium extraction system utilizing Cyanex 272 as iron-fixed reagent. DESALINATION, [PMID:] [10.1016/j.desal.2025.118574] |
| 11. Fan Luo, Changchao Zhang, Yuyang Zhang, Jie Han, Ziteng Wang, Wenge Yang, Yonghong Hu. (2024) Determination and analysis of 4-hydroxyphenylacetamide solubility in different solvents by Hansen solubility parameters, solvent effect and thermodynamic properties. JOURNAL OF MOLECULAR LIQUIDS, [PMID:] [10.1016/j.molliq.2024.125673] |
| 12. Siyu Gan, Zhenxing Wang, Chunli Zheng, Zishen Lin, Ai-bin Zhu, Bo Lai. (2024) Enhanced Treatment of Antimony Mine Wastewater by Sulfidated Micro Zerovalent Iron (S-mZVI). LANGMUIR, [PMID:39358310] [10.1021/acs.langmuir.4c02741] |
| 13. Qingsheng Wang, Wen Huang, Qian Sun, Mengqi Le, Lili Cai, Yong-Guang Jia. (2025) Facially amphiphilic skeleton-derived antibacterial crown ether/silver ion complexes. Soft Matter, [PMID:39989433] [10.1039/D4SM01192A] |
| 14. Wenjun Rao, Xin Li, Linghua Ouyang, Shuilan Zhu, Shuai Hu, Linfeng Yuan, Jinying Zhou. (2024) Investigation of the quality of rapeseed oil derived from different varieties and growth periods based on GC-IMS technique. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2024.111357] |
| 15. Yinfeng Li, Huaiyuan Cao, Zixiao Xue, Ran Luo, Xuejie Lin, Yuhua Xue, Long Zhang, Jin He. (2024) Optical bonding utilizing aqueous Al2O3–P2O5-lactate sol-gel adhesives. CERAMICS INTERNATIONAL, [PMID:] [10.1016/j.ceramint.2024.06.169] |
| 16. Qiuyan Lin, Na Zheng, Qirui An, Zhifei Xiu, Xiaoqian Li, Huicheng Zhu, Changcheng Chen, Yunyang Li, Sujing Wang. (2024) Phthalate monoesters accumulation in residential indoor dust and influence factors. SCIENCE OF THE TOTAL ENVIRONMENT, [PMID:39047842] [10.1016/j.scitotenv.2024.174900] |
| 17. Runzhe Liu, Zihao Wang, Wenbo Yang, Jinzhe Cao, Shengyang Tao. (2024) Self-optimizing Bayesian for continuous flow synthesis process. Digital Discovery, 3 (10): (1958-1966). [PMID:] [10.1039/D4DD00223G] |
| 18. Xue Tiange, Huang Zeya, Zhang Xiaotian, Meng Meng, Yu Shixiang, Chen Tian, Fu Renli. (2024) Study on high temperature reliability of electrical interconnection material of SiC pressure sensor. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS, 35 (10): (1-12). [PMID:] [10.1007/s10854-024-12308-x] |
| 19. Wanyu Li, Jiamin Ye, Zhiwen Jia, Haipeng Yu, Linghao Li, Hong Wang, Enchen Jiang, Yan Sun, Xiwei Xu. (2024) The full utilization of bagasse via deep eutectic solvent pretreatment for low-condensed lignin and cellulose smart indicator film. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2024.151653] |
| 20. Liyun Ma, Si-Min Liu, Lin Yao, Li Xu. (2014) Preparation and chromatographic performance evaluation of cucurbit[7]uril immobilized silica. JOURNAL OF CHROMATOGRAPHY A, [PMID:25528071] [10.1016/j.chroma.2014.12.002] |
| 21. Di Sun, Wenze Cheng, Zheng Li, Hui Yao, Mafeng Liu, Mingshu Wang, Shun Chen, Yukun Zhu, Jingming Wang, Yuan Deng, Funeng Xu, Xumin Ou, Renyong Jia, Dekang Zhu, Xinxin Zhao, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Bin Tian, Yu He, Zhen Wu, Anchun Cheng. (2025) Targeting the Pan-Viral Host Protein HSPA8 with Oxymatrine as a Novel Therapy against Duck Hepatitis A Virus Infection. POULTRY SCIENCE, [PMID:41455214] [10.1016/j.psj.2025.106336] |
