p-Aminophenylmercuric acetate（APMA） - Moligand™, ≥98% , CAS No.6283-24-5

CAS: 6283-24-5 Cat. No.: P649286 Peso molecular: 351.75 Número EC: 228-497-1

GRADE & PURITY Moligand™, ≥98%

Synonyms

p-Aminophenylmercuric Acetate - CAS 6283-24-5 - Calbiochem | Mercury, (acetato-O)(4-aminophenyl)- | Mercury, (acetato-.kappa.O)(4-aminophenyl)- | acetoxymercurianiline | FT-0617597 | 4-Aminophenylmercury acetate | 1,3-Bis(2,4-diaminophenoxy)propane 4HCl,

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP). P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction. p-Aminophenylmercuric acetate promotes the shedding of betacellulin precursor (pro-BTC). p-Aminophenylmercuric acetate influences the binding of agonists and antagonists to the opiate receptor .

In Vitro

p-Aminophenylmercuric acetate (APMA) (0-30 µM; 20 min) decreases the apparent number of dihydromorphine binding sites and increases the sensitivity of agonist binding to the inhibitory effects of sodium in rat brain homogenate. p-Aminophenylmercuric acetate (0.5 mM; 30 min) activates the MMP-2 and MMP-9. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

Specifications

Sinónimos

p-Aminophenylmercuric Acetate - CAS 6283-24-5 - Calbiochem | Mercury, (acetato-O)(4-aminophenyl)- | Mercury, (acetato-.kappa.O)(4-aminophenyl)- | acetoxymercurianiline | FT-0617597 | 4-Aminophenylmercury acetate | 1, 3-Bis(2, 4-diaminophenoxy)propane 4HCl,

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

p-Aminophenylmercuric acetate is an organomercurial activator of matrix metalloproteinases (MMP) . P-Aminophenylmercuric acetate participates in the activation and inhibition of MMP-8 by attacking protein sulfhydryl or inducing cysteine switching reaction

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CC(=O)O[Hg]C1=CC=C(C=C1)N
• IUPAC Name: acetyloxy-(4-aminophenyl)mercury
• InChIKey: RXSUFCOOZSGWSW-UHFFFAOYSA-M
• INCHI: 1S/C6H6N.C2H4O2.Hg/c7-6-4-2-1-3-5-6;1-2(3)4;/h2-5H,7H2;1H3,(H,3,4);/q;;+1/p-1
• Isómeros SMILES: CC(=O)O[Hg]C1=CC=C(C=C1)N
• Peso molecular: 351.75

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Benzene and substituted derivatives
      • Subclass Aniline and substituted anilines

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Benzene and substituted derivatives
• Subclass: Aniline and substituted anilines
• Intermediate Tree Nodes: Not available
• Direct Parent: Aniline and substituted anilines
• Alternative Parents: Metal aryls Aryl mercury compounds Organic transition metal salts Monocarboxylic acids and derivatives Carboxylic acids Primary amines Organic oxides Hydrocarbon derivatives Carbonyl compounds Organic cations
• Molecular Framework: Not available
• Substituents: Aniline or substituted anilines - Aryl mercury compound - Metal aryl - Carboxylic acid derivative - Carboxylic acid - Monocarboxylic acid or derivatives - Organic transition metal salt - Organic nitrogen compound - Primary amine - Organooxygen compound - Organonitrogen compound - Organometallic compound - Organomercurial-compound - Organic transition metal moeity - Carbonyl group - Amine - Organic oxygen compound - Hydrocarbon derivative - Organic oxide - Organic cation - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as aniline and substituted anilines. These are organic compounds containing an aminobenzene moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: DMSO : 125 mg/mL (355.37 mM; ultrasonic and warming and heat to 60°C)
• Peso molecular: 351.750 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 353.034 Da
• Monoisotopic Mass: 353.034 Da
• Topological Polar Surface Area: 52.300 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 155.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

XLogP3

Referencias

1. Feng Wu, Yu Huang, Xian Yang, Jing-Jing Hu, Xiaoding Lou, Fan Xia, Yanlin Song, Lei Jiang.  (2021)  Tunning Intermolecular Interaction of Peptide-Conjugated AIEgen in Nano-Confined Space for Quantitative Detection of Tumor Marker Secreted from Cells.  ANALYTICAL CHEMISTRY,      [PMID:34809422] [10.1021/acs.analchem.1c04422]

2. Zhu Dan, Zhong Hanyan, Shi Jingzhan, Liu Qiang, Wang Yiping.  (2025)  Ratiometric surface-enhanced Raman scattering quantification of extracellular matrix metalloproteinase-2 activity for tumor diagnosis.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,      [PMID:39966175] [10.1007/s00216-025-05792-5]