10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM
In Vitro
p-Ethynylphenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin. p-Ethynylphenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors (5-HT 1 , 5-HT 2 , 5-HT 4 , 5-HT 5 , 5-HT 6 , and 5-HT 7 ). MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue . p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (200 g) Dosage: 30 mg/kg Administration: Intraperitoneal injection Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain.
IC50& Target:Ki: 32.6 μM (TPH)
Specifications
Especificaciones y pureza
10mM in DMSO
Mecanismos bioquímicos y fisiológicos
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM.
Condiciones de almacenamiento de almacenamiento
Desiccated, Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Nombres e identificadores
Isómeros SMILES
C#CC1=CC=C(C=C1)C[C@@H](C(=O)O)N.Cl
PubChem CID
127264445
Peso molecular
225.67
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
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