P-gp inhibitor 1 - 10mM in DMSO , CAS No.2050747-49-2

CAS: 2050747-49-2 Cat. No.: P654901 Peso molecular: 517.62 PubChem CID: 132822387

GRADE & PURITY 10mM in DMSO

Storage

Protected from light,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein -mediated multidrug resistance.

In Vitro

P-gp inhibitor 1 (12k) possesses high potency ( EC 50 =57.9±3.5 nM), low cytotoxicity, and long duration of activity in reversing doxorubicin (DOX) resistance in K562/A02 cells (1 μM, 80 minutes). P-gp inhibitor 1 also boosts the potency of other MDR-related cytotoxic agents with different structures, increases accumulation of DOX, blocks Pgp-mediated Rh123 efflux, and suppresses P-gp ATPase activity in K562/A02 MDR cells (0.1, 1, 5 μM, 1 hour). MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: K562/A02 cell Concentration: 0.1, 0.5, or 2.0 μM Incubation Time: 72 hours Result: MDR reversal by 12k was not caused by a decreased protein expression but instead most likely due to direct inhibition of P-gp efflux.

IC50& Target:P-glycoprotein

Specifications

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein -mediated multidrug resistance.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -80°C

Enviado en

Dry ice packs + Cold packs

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Tipo de acción

INHIBITOR

Nombres e identificadores

• Isómeros SMILES: COC1=C(C=C2CN(CCC2=C1)CCC3=CC=C(C=C3)NC4=NC(=NC5=CC=CC=C54)C6=CC=NC=C6)OC
• PubChem CID: 132822387
• Peso molecular: 517.62