Palomid 529 (P529) - 10mM in DMSO , Serine/threonine-protein kinase mTOR inhibitor, CAS No.914913-88-5, Serine/threonine-protein kinase mTOR inhibitor

CAS: 914913-88-5 Cat. No.: P580480 Peso molecular: 406.43 Número EC: 806-313-6

GRADE & PURITY 10mM in DMSO

Synonyms

8-(1-hydroxyethyl)-2-methoxy-3-((4-methoxyphenyl)methoxy)-6h-dibenzo(b,d)pyran-6-one | (z)-ocimene | Oroxylin A, >=98% (HPLC) | SCHEMBL290034 | SG00529 | SW219676-1 | Palomid 529 (P529) | 6-methoxy-4'-methylapigenin | RES-529 | s2238 | 8-(1-Hydroxyethyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Palomid 529 (P529) inhibits both the mTORC1 and mTORC2 complexes, reduces phosphorylation of pAktS473, pGSK3βS9, and pS6 but no effect observed on pMAPK or pAktT308.
A novel PI3K/Akt/mTOR inhibitor with a GI50 of <35 μM in the NCI-60 cell lines panel.

Specifications

Sinónimos

8-(1-hydroxyethyl)-2-methoxy-3-((4-methoxyphenyl)methoxy)-6h-dibenzo(b, d)pyran-6-one | (z)-ocimene | Oroxylin A, >=98% (HPLC) | SCHEMBL290034 | SG00529 | SW219676-1 | Palomid 529 (P529) | 6-methoxy-4'-methylapigenin | RES-529 | s2238 | 8-(1-Hydroxyethyl)-

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Palomid 529 is a novel inhibitor of PI3K, Akt, and mTOR. Palomid 529 is an inhibitor of the TORC1 and TORC2 complexes and inhibits Akt signaling and mTOR signaling in similar ways in vasculature and tumor. Palomid 529 is an inhibitor of tumor growth, angi

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

Serine/threonine-protein kinase mTOR inhibitor

Propiedades del producto

• ALogP: 4

Nombres e identificadores

• Sonrisas canónicas: CC(C1=CC2=C(C=C1)C3=CC(=C(C=C3OC2=O)OCC4=CC=C(C=C4)OC)OC)O
• IUPAC Name: 8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]benzo[c]chromen-6-one
• InChIKey: YEAHTLOYHVWAKW-UHFFFAOYSA-N
• INCHI: 1S/C24H22O6/c1-14(25)16-6-9-18-19-11-22(28-3)23(12-21(19)30-24(26)20(18)10-16)29-13-15-4-7-17(27-2)8-5-15/h4-12,14,25H,13H2,1-3H3
• Isómeros SMILES: CC(C1=CC2=C(C=C1)C3=CC(=C(C=C3OC2=O)OCC4=CC=C(C=C4)OC)OC)O
• WGK Alemania: 3
• RTECS: HP8756500
• Peso molecular: 406.43
• Reaxy-Rn: 15029869
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=15029869&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Phenylpropanoids and polyketides
    • Clase Coumarins and derivatives

• Kingdom: Organic compounds
• Superclass: Phenylpropanoids and polyketides
• Clase: Coumarins and derivatives
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Coumarins and derivatives
• Alternative Parents: Isocoumarins and derivatives 2-benzopyrans 1-benzopyrans Phenoxy compounds Methoxybenzenes Anisoles Pyranones and derivatives Alkyl aryl ethers Heteroaromatic compounds Secondary alcohols Lactones Oxacyclic compounds Organic oxides Hydrocarbon derivatives Aromatic alcohols
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Coumarin - Isocoumarin - Benzopyran - 2-benzopyran - 1-benzopyran - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Alkyl aryl ether - Pyranone - Monocyclic benzene moiety - Benzenoid - Pyran - Heteroaromatic compound - Lactone - Secondary alcohol - Organoheterocyclic compound - Oxacycle - Ether - Organic oxygen compound - Organooxygen compound - Hydrocarbon derivative - Alcohol - Organic oxide - Aromatic alcohol - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as coumarins and derivatives. These are polycyclic aromatic compounds containing a 1-benzopyran moiety with a ketone group at the C2 carbon atom (1-benzopyran-2-one).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

YES1 Tclin Tyrosine-protein kinase YES (2781 Activities)

Discover Target: YES1

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HEK293 (82097 Activities)

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Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in DMSO (81 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), and ethanol (<1 mg/ml at 25 °C).
• Peso molecular: 406.400 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 406.142 Da
• Monoisotopic Mass: 406.142 Da
• Topological Polar Surface Area: 74.200 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 574.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1