Pam2CSK4 TFA, CAS No.868247-72-7(free base)

CAS: 868247-72-7(free base) Cat. No.: P288184 Peso molecular: 1271.82 (free base)

GRADE & PURITY Moligand™, ≥95%

Descripción general

Pam2CSK4 (TFA), a lipopeptide, is a TLR6-independent TLR2 ligand and agonist. Pam2CSK4 (TFA) promotes platelet aggregation, and increases platelet adhesion to collagen-coated surfaces in a TLR2/NF-κB/BTK-dependent manner. Pam2CSK4 (TFA) also activates iNOS expression and NO production in mouse macrophages .

Specifications

Product Name

Pam2CSK4 TFA, CAS No.868247-72-7(free base)

Grado

Moligand™

Especificaciones y pureza

Moligand™, ≥95%

Mecanismos bioquímicos y fisiológicos

Toll-like receptor 2/6 (TLR2/6) agonist. Induces TNF-αproduction in human mononuclear cells. Also induces proliferation and activation of mouse splenic B cells.

Secuencia

CSKKKK(Modifications: Cys =S-[2, 3-Bis(palmitoyloxy)-(2-R)-propyl]-Cys)

Tipo de acción

AGONIST

CAS

868247-72-7(free base)

Tipo de molécula

Small molecule

Almacenamiento y envío

Condiciones de almacenamiento de almacenamiento

Protected from light,Store at -20°C

Enviado en

Ice chest + Ice pads

Objetivos asociados (humanos)

TLR2 Tchem Toll-like receptor 2 (2 Activities)

Discover Target: TLR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

THP-1 (11052 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TLR2 Tchem Toll-like receptor 2 (975 Activities)

Discover Target: TLR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Objetivos asociados (no humanos)

Mus musculus (284745 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

RAW264.7 (28094 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Información genética

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