Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Desiccated,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 14 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Paroxetine hydrochloride hemihydrate is a potent selective serotonin-reuptake inhibitor, commonly prescribed as an antidepressant and has GRK2 inhibitory ability with IC 50 of 14 μM.
| ALogP | 3.5 |
|---|
| Isómeros SMILES | C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C1CNC[C@H]([C@@H]1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.O.Cl.Cl |
|---|---|
| WGK Alemania | 3 |
| RTECS | TM4569320 |
| CAS alternativo | 78246-49-8 |
| PubChem CID | 5282487 |
| Peso molecular | 374.83 |
| Reaxy-Rn | 7471375 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Rotación específica [α] | -90°C |
|---|---|
| Punto de fusión (°C) | 137-139°C |
| 1. Ru Cheng, Aoqi Song, Jingjing Jiang, Xijier Qiaolongbatu, Zhenghua Wu, Feng Qian, Shuyu Shen, Liwen Zhang, Zhiyu Wang, Wenjuan Zhao, Yuefen Lou. (2025) Berberine Alleviates Chronic Restraint Stress-Induced Depression-Like Behavior by Modulating Gut Microbiota and SCFA Production in Mice. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY, [PMID:40891178] [10.1002/bab.70043] |
| 2. Pan Su, Mengdi Wu, Xiaoting Yin, Mengyuan Li, Yucheng Li, Ming Bai, Baoying Wang, Erping Xu. (2023) Modified Xiaoyao San reverses lipopolysaccharide-induced depression-like behavior through suppressing microglia M1 polarization via enhancing autophagy involved in PI3K/Akt/mTOR pathway in mice. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37263314] [10.1016/j.jep.2023.116659] |
| 3. Aoqi Song, Zhenghua Wu, Wenjuan Zhao, Wenqing Shi, Ru Cheng, Jingjing Jiang, Zhuojun Ni, Han Qu, Xijier Qiaolongbatu, Guorong Fan, Yuefen Lou. (2022) The Role and Mechanism of Hyperoside against Depression-like Behavior in Mice via the NLRP1 Inflammasome. Medicina-Lithuania, 58 (12): (1749). [PMID:36556951] [10.3390/medicina58121749] |
| 4. Aoqi Song, Ru Cheng, Jingjing Jiang, Han Qu, Zhenghua Wu, Feng Qian, Shuyu Shen, Liwen Zhang, Zhiyu Wang, Wenjuan Zhao, Yuefen Lou. (2024) Antidepressant-like effects of hyperoside on chronic stress-induced depressive-like behaviors in mice: Gut microbiota and short-chain fatty acids. JOURNAL OF AFFECTIVE DISORDERS, [PMID:38492650] [10.1016/j.jad.2024.03.017] |
| 5. Mengdi Wu, Xiangli Yan, Huang Huang, Xiuhui Guo, Ming Bai, Baoying wang, Pan Su, Yucheng Li, Erping Xu. (2024) Integration of network pharmacology and experimental verification to reveal the active components and molecular mechanism of modified Danzhi Xiaoyao San in the treatment of depression. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:39197805] [10.1016/j.jep.2024.118739] |
| 6. Pan Su, Liming Liu, Yuhang Gong, Shuaijun Peng, Xiangli Yan, Ming Bai, Erping Xu, Yucheng Li. (2024) Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:39492132] [10.1016/j.intimp.2024.113538] |
| 7. Baoying Wang, Lei Tian, Mengdi Wu, Duo Zhang, Xiangli Yan, Ming Bai, Yucheng Li, Pan Su, Erping Xu. (2024) Modified Danzhi XiaoyaoSan inhibits neuroinflammation via regulating TRIM31/NLRP3 inflammasome in the treatment of CUMS depression. EXPERIMENTAL GERONTOLOGY, [PMID:38729250] [10.1016/j.exger.2024.112451] |
| 8. Su Pan, Li Zibo, Yan Xiangli, Wang Baoying, Bai Ming, Li Yucheng, Xu Erping. (2024) Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice. INFLAMMATION RESEARCH, [PMID:38587532] [10.1007/s00011-024-01876-7] |
| 9. Peng Shuaijun, Su Pan, Liu Liming, Li Zibo, Liu Yuan, Tian Lei, Bai Ming, Xu Erping, Li Yucheng. (2025) Formononetin ameliorates depression-like behaviors through rebalancing microglia M1/M2 polarization and inhibiting NLRP3 inflammasome: involvement of activating PPARα-mediated autophagy. MOLECULAR MEDICINE, 31 (1): (1-20). [PMID:40275171] [10.1186/s10020-025-01217-2] |
| 10. Xinxin Zheng, Sidi Cun, Jiatai Yin, Xue Zhao, Yunshan Wang, Jing Wang, Qian Li, Xinfeng Zhao. (2025) Immobilizing the Endogenous 5-Hydroxytryptamine Transporter by Ligand-Directed and Proximity-Catalyzed Acyl Imidazole Chemistry for Affinity Chromatographic Analysis. ANALYTICAL CHEMISTRY, [PMID:40317770] [10.1021/acs.analchem.5c01334] |
| 11. Xue Zhao, Yunshan Wang, Jiatai Yin, Sidi Cun, Yuanyuan Ou, Qian Li, Xinfeng Zhao, Yajun Zhang. (2025) Integrating click chemistry into protein expression for efficient preparation of immobilized protein bio-surface with enhanced stability and reproducibility in affinity chromatography. ANALYTICA CHIMICA ACTA, [PMID:40409903] [10.1016/j.aca.2025.344142] |
| 12. Zhao Xue, Yu Yi, Yang Lili, Liu Hui, Lei Ting. (2025) Screening of selective serotonin reuptake inhibitors from Cyperus rotundus using immobilized neurotransmitter transporter affinity chromatography for antidepressant discovery. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, [PMID:41062859] [10.1007/s00216-025-06105-6] |
| 13. Tian Lei, Su Pan, Feng Gang, Peng Shuaijun, Liu Liming, Yan Xiangli, Liu Xianghua, Li Yucheng, Bai Ming, Wang Baoying, Xu Erping. (2025) Modified Xiaoyao San ameliorates LPS-induced depression-like behavior by inhibiting NLRP3-mediated microglial pyroptosis. METABOLIC BRAIN DISEASE, 40 (8): (324). [PMID:41273446] [10.1007/s11011-025-01751-2] |
| 14. Gao Xiang, Hou Yujiao, Lin Fang, Wen Limei, Guo Yali, Kong Weijun, Hu Junping, Yang Jianhua. (2026) A rime-like Au-Pt nanostructured film and polyaniline-MIP based electrochemical sensor for olanzapine detection. MICROCHIMICA ACTA, 193 (4): (233). [PMID:] [10.1007/s00604-026-07857-3] |
Our grade selection guide covers purity, stabilizer status, and application suitability for all variants in our catalog.
View Moligand™ grade guide →
