≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at 2-8°C Ships Wet ice Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Parsaclisib hydrochloride (INCB050465 hydrochloride) is a potent, selective and orally active inhibitor of PI3Kδ , with an IC 50 of 1 nM at 1 mM ATP. Parsaclisib hydrochloride shows approximately 20000-fold selectivity over other PI3K class I isoforms. Parsaclisib hydrochloride can be used for the research of relapsed or refractory B-cell malignancies
In Vitro
Parsaclisib (0.1-3000 nM; 4 d) inhibits proliferation of MCL and DLBCL cell lines. Parsaclisib (0.1-1000 nM; 2 h) inhibits anti-IgM-induced pAKT (Ser473) in the Ramos Burkitt’s lymphoma cell line, with an IC 50 of 1 nM. Parsaclisib inhibits the proliferation of human, dog, rat, and mouse primary B cells after activation of these receptors, with IC 50 s ranging from 0.2 to 1.7 nM. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: Jeko-1, Mino, JVM2, Rec-1, Pfeiffer, SU-DHL-5, SU-DHL-6, WSU-NHL, SU-DHL-4, SU-DHL-8, and WILL-2 cells Concentration: 0.1-3000 nM Incubation Time: 4 days Result: Resulted in a maximal inhibition of 70-90%, with IC 50 s of ≤10 nM in the four MCL cell lines. Pfeiffer, SU-DHL-5, SU-DHL-6, and WSU-NHL were highly sensitive, with IC 50 s from 2 to 8 nM.
In Vivo
Parsaclisib (10 mg/kg; oral gavage twice daily for 7-19 days) inhibits tumor growth in the BALB/c mice bearing the A20 murine lymphoma cells. Parsaclisib (0.1-10 mg/kg; p.o. twice daily) slows Pfeiffer xenograft tumor growth in a dose-dependent manner. And Parsaclisib was well tolerated. Parsaclisib (0.5-1 mg/kg; a single p.o.) inhibits pAKT (Ser473) in Pfeiffer subcutaneous mouse xenograft models. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female BALB/c mice (5-9 weeks) were inoculated with A20 cellsDosage: 10 mg/kg Administration: Oral gavage twice daily for 7-19 days Result: Resulted in significant tumor growth inhibition (TGI). Reduced the percentage of Tregs (CD4 + CD25 + FOXP3 + ) in tumors and spleens. Increased the ratio of CD4 + and CD8 + T cells to Tregs in spleens and tumors. Decreased the number of CD4 + CD44 high and CD8 + CD44 high T cells in both spleens and tumors.
Form:Solid
IC50& Target:PI3Kδ 1 nM (IC 50 )
| Sonrisas canónicas | CCOC1=C(C(=C(C=C1C(C)N2C3=NC=NC(=C3C(=N2)C)N)Cl)F)C4CC(=O)NC4.Cl |
|---|---|
| IUPAC Name | (4R)-4-[3-[(1S)-1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one;hydrochloride |
| InChIKey | TWHUONANZMKBKX-ACMTZBLWSA-N |
| INCHI | 1S/C20H22ClFN6O2.ClH/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20;/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26);1H/t10-,11-;/m0./s1 |
| Isómeros SMILES | CCOC1=C(C(=C(C=C1[C@H](C)N2C3=NC=NC(=C3C(=N2)C)N)Cl)F)[C@H]4CC(=O)NC4.Cl |
| CAS alternativo | 1995889-48-9 |
| PubChem CID | 122507744 |
| Peso molecular | 469.34 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Pyrrolidines |
| Subclass | Phenylpyrrolidines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylpyrrolidines |
| Alternative Parents | Pyrazolopyrimidines Phenoxy compounds Phenol ethers Fluorobenzenes Chlorobenzenes Alkyl aryl ethers Pyrrolidine-2-ones Pyrimidines and pyrimidine derivatives N-acyl amines Imidolactams Pyrroles Pyrazoles Heteroaromatic compounds Lactams Amino acids and derivatives Carboxylic acid amides Azacyclic compounds Primary amines Organopnictogen compounds Organofluorides Organochlorides Organic oxides Hydrochlorides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | 3-phenylpyrrolidine - Pyrazolopyrimidine - Phenoxy compound - Phenol ether - Halobenzene - Fluorobenzene - Chlorobenzene - Alkyl aryl ether - Fatty acyl - Imidolactam - Benzenoid - 2-pyrrolidone - Pyrrolidone - Pyrimidine - N-acyl-amine - Fatty amide - Monocyclic benzene moiety - Heteroaromatic compound - Pyrrole - Pyrazole - Azole - Lactam - Carboxamide group - Amino acid or derivatives - Azacycle - Ether - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Hydrochloride - Primary amine - Organooxygen compound - Organonitrogen compound - Organofluoride - Organochloride - Organohalogen compound - Amine - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as phenylpyrrolidines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrrolidine ring through a CC or CN bond. Pyrrolidine is a five-membered saturated aliphatic heterocycle with one nitrogen atom and four carbon atoms. |
| External Descriptors | Not available |
| Solubilidad | DMSO : 240 mg/mL (511.36 mM; Need ultrasonic) H2O : 100 mg/mL (213.07 mM; Need ultrasonic) |
|---|---|
| Peso molecular | 469.300 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 5 |
| Exact Mass | 468.124 Da |
| Monoisotopic Mass | 468.124 Da |
| Topological Polar Surface Area | 108.000 Ų |
| Heavy Atom Count | 31 |
| Formal Charge | 0 |
| Complexity | 632.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
