Pavurutamab , CAS No.2250292-39-6

CAS: 2250292-39-6 Cat. No.: P648319

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti- CD3 and anti- B cell maturation antigens ( BCMA ). Pavurutamab has an extended half-life based on Pacanalotamab . The Fc of Pavurutamab is coupled to molecules to improve pharmacokinetic parameters. Pavurutamab has potential applications in immune regulation and multiple myeloma (MM)

In Vitro

Pavurutamab (0-10000 pM; 48 h) induces CD69 + , CD25 + T cell activation and IFNγ, TNFα, IL-2, IL-4, IL-6, IL-10 cytokine secretion . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pavurutamab (0.02, 0.2 and 2 mg/kg; i.v.; single dose on days 3, 8, 13) reduces tumor volume with time and dose dependent manner in mouse xenograft models. Pavurutamab (0.005, 0.05 and 0.5 mg/kg; i.v.; every 5 days for 6 administrations, lasting for 30 days) reduces tumor volume and increases survival with time and dose dependent manner in NOD/SCID mice transplanted with L-363 multiple myeloma (MM) cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female NOD/SCID mice transplanted with NCI-H929 MM cells mixed with PBMCs. Dosage: 0.02, 0.2 and 2 mg/kg. Administration: Intravenous injection; single dose on days 3, 8, 13. Result: Reduced tumor volume. Animal Model: NOD/SCID mice orthotopically transplanted with L-363 MM cells. Dosage: 0.005, 0.05 and 0.5 mg/kg. Administration: Intravenous injection; every 5 days for 6 administrations, starting from day 9 and lasting for 30 days. Result: Reduced tumor volume and increased survival.

IC50& Target:B cell maturation antigens, BCMA

Especificaciones

Mecanismos bioquímicos y fisiológicos

Pavurutamab (AMG-701) is a bispecific T cell engager molecule that anti- CD3 and anti- B cell maturation antigens ( BCMA ). Pavurutamab has an extended half-life based on Pacanalotamab ( HY-P99798 ). The Fc of Pavurutamab is coupled to molecules to improv

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

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Tipo de acción

INHIBITOR

Preguntas frecuentes

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2250292-39-6.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.