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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items PD-1/PD-L1 inhibitor 1 - 10mM in DMSO , CAS No.1675201-83-8
GRADE & PURITY 10mM in DMSO
Synonyms
(2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylicacid；(S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid；PD1-PDL1-IN1
Shipped In
Dry ice packs + Cold packs
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Why this grade 10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general Shipped at 4°C. Store at -20°C.
Specifications Sinónimos
(2S)-1-[[2, 6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylicacid；(S)-1-(2, 6-dimethoxy-4-((2-methyl-[1, 1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid；PD1-PDL1-IN1
Especificaciones y pureza
10mM in DMSO
Mecanismos bioquímicos y fisiológicos
In the cell-free HTRF test, PD-1/PD-L1 inhibitor 1 blocked the PD-1/PD-L1 interaction with an IC50 of 6 nM.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Nombres e identificadores Sonrisas canónicas CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCCC4C(=O)O)OC IUPAC Name (2S)-1-[[2,6-dimethoxy-4-[(2-methyl-3-phenylphenyl)methoxy]phenyl]methyl]piperidine-2-carboxylic acid InChIKey ZBOYJODMIAUJHH-SANMLTNESA-N INCHI 1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1 Isómeros SMILES CC1=C(C=CC=C1C2=CC=CC=C2)COC3=CC(=C(C(=C3)OC)CN4CCCC[C@H]4C(=O)O)OC PubChem CID 91663303 Peso molecular 475.6
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Clase Piperidines Subclass Benzylpiperidines Intermediate Tree Nodes Not available Direct Parent N-benzylpiperidines Alternative Parents Biphenyls and derivatives L-alpha-amino acids Dimethoxybenzenes Piperidinecarboxylic acids Phenylmethylamines Phenoxy compounds Anisoles Benzylamines Toluenes Alkyl aryl ethers Aralkylamines Trialkylamines Amino acids Monocarboxylic acids and derivatives Carboxylic acids Azacyclic compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds Molecular Framework Aromatic heteromonocyclic compounds Substituents N-benzylpiperidine - Biphenyl - Alpha-amino acid - Alpha-amino acid or derivatives - Dimethoxybenzene - M-dimethoxybenzene - L-alpha-amino acid - Piperidinecarboxylic acid - Anisole - Methoxybenzene - Benzylamine - Phenoxy compound - Phenol ether - Phenylmethylamine - Alkyl aryl ether - Aralkylamine - Toluene - Benzenoid - Monocyclic benzene moiety - Amino acid - Tertiary amine - Tertiary aliphatic amine - Amino acid or derivatives - Monocarboxylic acid or derivatives - Ether - Carboxylic acid - Carboxylic acid derivative - Azacycle - Organic oxide - Amine - Organic nitrogen compound - Carbonyl group - Organic oxygen compound - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Aromatic heteromonocyclic compound Descripción This compound belongs to the class of organic compounds known as n-benzylpiperidines. These are heterocyclic Compounds containing a piperidine ring conjugated to a benzyl group through one nitrogen ring atom. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Peso molecular 475.600 g/mol XLogP3 3.400 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 9 Exact Mass 475.236 Da Monoisotopic Mass 475.236 Da Topological Polar Surface Area 68.200 Ų Heavy Atom Count 35 Formal Charge 0 Complexity 639.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
Citations of This Product Referencias 1. Yan-Li Xing, Hong-Mei Li, Xiao-Ming Pang, Ying Zhang, Ting Yang, Yan-Hong Li, De-Chuan Liu, Yang-Yang Ma, Li-Zhi Niu. (2025) Irreversible electroporation combined with checkpoint blockade stimulates antitumor immune response in a hepatocellular carcinoma mouse model. World Journal of Gastrointestinal Oncology, 17 (9): (110166). [PMID:40977659 ] [10.4251/wjgo.v17.i9.110166 ] 2. Jian Yu, Jiangtao Wang, Ning Feng, Cancan Wang, Bohua Ma, Yuanming Zhang. (2026) Myd88 and Sqstm1 as novel biomarkers for pyroptosis-driven immune checkpoint inhibitors-related myocarditis. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:41653556 ] [10.1016/j.intimp.2026.116336 ] 3. Jian Yu, Jiangtao Wang, Xinya Liu, Jing Shi, Yang Zhang, Cancan Wang, Li Wu, Yuanming Zhang. (2026) Combining multi-omics analysis methods to identify biomarkers for mitophagy involved in immune checkpoint inhibitors-related myocarditis. Frontiers in Immunology, [PMID:42093991 ] [10.3389/fimmu.2026.1691848 ]
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