Peramivir Trihidrato - ≥99% , Neuraminidase inhibitor, CAS No.1041434-82-5, Neuraminidase inhibitor

CAS: 1041434-82-5 Cat. No.: P129200 Peso molecular: 382.45

GRADE & PURITY ≥99%

Synonyms

PeramivirTrihydrate | Rapivab (TN) | BAICALEIN [USP-RS] | (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid;trihydrate | s2716 | (1S,2S,3R,4R)-3-((1S)-1-acetamido-2-ethylbutyl)-4-((amino(im

Storage

Protegido de la luz,Almacenar a -20°C,Cargado con argón

Shipped In

Hielera + almohadillas de hielo

Descripción general

El peramivir trihidrato es un trihidrato del agente antiinfeccioso peramivir (RWJ-270201,BCX-1812), que es un análogo del estado de transición y un potente inhibidor específico de la neuraminidasa viral de la gripe con un IC50 medio de 0,09 nM.

Specifications

Sinónimos

PeramivirTrihydrate | Rapivab (TN) | BAICALEIN [USP-RS] | (1S, 2S, 3S, 4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid;trihydrate | s2716 | (1S, 2S, 3R, 4R)-3-((1S)-1-acetamido-2-ethylbutyl)-4-((amino(im

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Peramivir es un medicamento antivírico experimental desarrollado por BioCryst Pharmaceuticals para el tratamiento de la gripe. Ha sido autorizado para el uso de urgencia en el tratamiento de determinados pacientes hospitalizados con gripe

Condiciones de almacenamiento de almacenamiento

Protegido de la luz, Almacenar a -20°C, Cargado con argón

Enviado en

Hielera + almohadillas de hielo

Tipo de acción

INHIBITOR

Mecanismo de acción

Neuraminidase inhibitor

Pureza

≥99%

Nombres e identificadores

• Pubchem Sid: 488197803
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488197803
• Sonrisas canónicas: CCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C.O.O.O
• IUPAC Name: (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid;trihydrate
• InChIKey: RFUCJKFZFXNIGB-ZBBHRWOZSA-N
• INCHI: 1S/C15H28N4O4.3H2O/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23;;;/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19);3*1H2/t9-,10+,11+,12-,13+;;;/m0.../s1
• Isómeros SMILES: CCC(CC)[C@@H]([C@H]1[C@@H](C[C@@H]([C@H]1O)C(=O)O)N=C(N)N)NC(=O)C.O.O.O
• Peso molecular: 382.45
• Reaxy-Rn: 30800735
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=30800735&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Gamma amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Gamma amino acids and derivatives
• Alternative Parents: Beta hydroxy acids and derivatives Cyclopentanols Acetamides Secondary carboxylic acid amides Guanidines Cyclic alcohols and derivatives Propargyl-type 1,3-dipolar organic compounds Monocarboxylic acids and derivatives Carboxylic acids Carboximidamides Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Gamma amino acid or derivatives - Beta-hydroxy acid - Cyclopentanol - Hydroxy acid - Cyclic alcohol - Acetamide - Carboxamide group - Guanidine - Secondary alcohol - Secondary carboxylic acid amide - Carboxylic acid - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Monocarboxylic acid or derivatives - Carboximidamide - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Alcohol - Organic nitrogen compound - Carbonyl group - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Aliphatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

HEK293 (82097 Activities)

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Objetivos asociados (no humanos)

Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO 0.2 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
• Sensibilidad: Light & Air sensitive
• Peso molecular: 382.450 g/mol
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 7
• Exact Mass: 382.243 Da
• Monoisotopic Mass: 382.243 Da
• Topological Polar Surface Area: 154.000 Ų
• Heavy Atom Count: 26
• Formal Charge: 0
• Complexity: 460.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 5
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 4

XLogP3

Referencias

1. Zhongnan Hu, Hui Liu, Weihua Wu, Tayyab Ali, Adam Junka, Farukh S. Sharopov, Xuan Zou, Shisong Fang, Yanfang Sun.  (2026)  Artemisia Extracts Suppress H1N1 Influenza A Virus Infection by Targeting Viral HA/NA Proteins and Modulating the TLR4/MyD88/NF-κB Signaling Axis.  Pharmaceuticals,  19  (2): (275).  [PMID:41754817] [10.3390/ph19020275]