PF-03049423 (Compound PF-5) is a potent and highly selective phosphodiesterase-5A inhibitor with an IC 50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke.
| Sonrisas canónicas | CCCOCCN1C2=CC(=NC=C2N=C(C1=O)N3CCN(CC3)CCO)C4=CN=C(C=C4)OC |
|---|---|
| IUPAC Name | 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2-one |
| InChIKey | MNLNAGRCHNMKKJ-UHFFFAOYSA-N |
| INCHI | 1S/C24H32N6O4/c1-3-13-34-14-11-30-21-15-19(18-4-5-22(33-2)26-16-18)25-17-20(21)27-23(24(30)32)29-8-6-28(7-9-29)10-12-31/h4-5,15-17,31H,3,6-14H2,1-2H3 |
| Isómeros SMILES | CCCOCCN1C2=CC(=NC=C2N=C(C1=O)N3CCN(CC3)CCO)C4=CN=C(C=C4)OC |
| PubChem CID | 24963293 |
| Peso molecular | 468.5 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Pyridines and derivatives |
| Subclass | Bipyridines and oligopyridines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Bipyridines and oligopyridines |
| Alternative Parents | N-arylpiperazines Pyridopyrazines Dialkylarylamines Alkyl aryl ethers N-alkylpiperazines Aminopyrazines Imidolactams Heteroaromatic compounds Trialkylamines 1,2-aminoalcohols Lactams Azacyclic compounds Dialkyl ethers Hydrocarbon derivatives Primary alcohols Organic oxides |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Bipyridine - N-arylpiperazine - Pyridopyrazine - Dialkylarylamine - Alkyl aryl ether - N-alkylpiperazine - Aminopyrazine - Imidolactam - Pyrazine - Piperazine - 1,4-diazinane - Heteroaromatic compound - 1,2-aminoalcohol - Tertiary aliphatic amine - Tertiary amine - Lactam - Alkanolamine - Azacycle - Dialkyl ether - Ether - Organic oxide - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Primary alcohol - Amine - Organic oxygen compound - Hydrocarbon derivative - Alcohol - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as bipyridines and oligopyridines. These are organic compounds containing two pyridine rings linked to each other. |
| External Descriptors | Not available |
