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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items PF 06281355 - ≥98%(HPLC) , CAS No.1435467-38-1
Synonyms
A902780 | 2-(6-(2,5-Dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide | EX-A4194 | 2-(6-(2,5-dimethoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2h)-yl) acetamide | PF-1355 | PF-06281355 (Free base) | SCHEMBL14936647 | PF 06281355
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Why this grade ≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Room temperature Ships Normal Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Sinónimos
A902780 | 2-(6-(2, 5-Dimethoxyphenyl)-4-oxo-2-thioxo-3, 4-dihydropyrimidin-1(2H)-yl)acetamide | EX-A4194 | 2-(6-(2, 5-dimethoxyphenyl)-4-oxo-2-thioxo-3, 4-dihydropyrimidin-1(2h)-yl) acetamide | PF-1355 | PF-06281355 (Free base) | SCHEMBL14936647 | PF 06281355
Especificaciones y pureza
≥98%(HPLC)
Mecanismos bioquímicos y fisiológicos
IC50 = 1.5 in human whole blood stimulated by selective myeloperoxidase (MPO) inhibitor (LPS) μ M）。 MPO is selective through a series of 50 receptors, enzymes, ion channels and transporters, including thyroid peroxidase. Inhibition of MPO activity in peri
Condiciones de almacenamiento de almacenamiento
Room temperature
Nombres e identificadores Pubchem Sid 504772163 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504772163 Sonrisas canónicas COC1=CC(=C(C=C1)OC)C2=CC(=O)NC(=S)N2CC(=O)N IUPAC Name 2-[6-(2,5-dimethoxyphenyl)-4-oxo-2-sulfanylidenepyrimidin-1-yl]acetamide InChIKey LJBUZOGABRDGBR-UHFFFAOYSA-N INCHI 1S/C14H15N3O4S/c1-20-8-3-4-11(21-2)9(5-8)10-6-13(19)16-14(22)17(10)7-12(15)18/h3-6H,7H2,1-2H3,(H2,15,18)(H,16,19,22) Isómeros SMILES COC1=CC(=C(C=C1)OC)C2=CC(=O)NC(=S)N2CC(=O)N PubChem CID 71568997 Peso molecular 321.35
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Clase Diazines Subclass Pyrimidines and pyrimidine derivatives Intermediate Tree Nodes Not available Direct Parent Phenylpyrimidines Alternative Parents Dimethoxybenzenes Phenoxy compounds Anisoles 2-Thiopyrimidines Pyrimidones Pyrimidinethiones Alkyl aryl ethers Hydropyrimidines Vinylogous amides Heteroaromatic compounds Thioureas Primary carboxylic acid amides Lactams Azacyclic compounds Carbonyl compounds Organic oxides Organonitrogen compounds Hydrocarbon derivatives Molecular Framework Aromatic heteromonocyclic compounds Substituents 4-phenylpyrimidine - P-dimethoxybenzene - Dimethoxybenzene - Phenoxy compound - Anisole - Phenol ether - Methoxybenzene - Alkyl aryl ether - 2-thiopyrimidine - Thiopyrimidine - Pyrimidinethione - Pyrimidone - Monocyclic benzene moiety - Hydropyrimidine - Benzenoid - Heteroaromatic compound - Vinylogous amide - Primary carboxylic acid amide - Thiourea - Carboxamide group - Lactam - Azacycle - Carboxylic acid derivative - Ether - Hydrocarbon derivative - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Carbonyl group - Organic nitrogen compound - Organic oxide - Aromatic heteromonocyclic compound Descripción This compound belongs to the class of organic compounds known as phenylpyrimidines. These are polycyclic aromatic compounds containing a benzene ring linked to a pyrimidine ring through a CC or CN bond. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solvent:DMSO, Max Conc. mg/mL: 6.43, Max Conc. mM: 20 with gentle warming Peso molecular 321.350 g/mol XLogP3 0.300 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 5 Rotatable Bond Count 5 Exact Mass 321.078 Da Monoisotopic Mass 321.078 Da Topological Polar Surface Area 126.000 Ų Heavy Atom Count 22 Formal Charge 0 Complexity 508.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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