≥97% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
PF-9366 PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor with IC50 of 420 nM and Kd of 170 nM.
Targets
hMat2A (Cell-free assay); hMat2A (Cell-free assay) 170 nM(Kd); 420 nM
| ALogP | 4.355 |
|---|---|
| hba_count | 2 |
| Enlace rotable | 4 |
| Pubchem Sid | 488198179 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488198179 |
| Sonrisas canónicas | CN(C)CCC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=C2)C4=CC=CC=C4 |
| IUPAC Name | 2-(7-chloro-5-phenyl-[1,2,4]triazolo[4,3-a]quinolin-1-yl)-N,N-dimethylethanamine |
| InChIKey | LYLASWLQCMKZAT-UHFFFAOYSA-N |
| INCHI | 1S/C20H19ClN4/c1-24(2)11-10-19-22-23-20-13-16(14-6-4-3-5-7-14)17-12-15(21)8-9-18(17)25(19)20/h3-9,12-13H,10-11H2,1-2H3 |
| Isómeros SMILES | CN(C)CCC1=NN=C2N1C3=C(C=C(C=C3)Cl)C(=C2)C4=CC=CC=C4 |
| PubChem CID | 12612431 |
| Peso molecular | 350.84 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Quinolines and derivatives |
| Subclass | Phenylquinolines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylquinolines |
| Alternative Parents | Phenylpyridines Chloroquinolines Triazolopyridines Aralkylamines Benzene and substituted derivatives Aryl chlorides Triazoles Heteroaromatic compounds Trialkylamines Azacyclic compounds Organochlorides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteropolycyclic compounds |
| Substituents | Phenylquinoline - 4-phenylpyridine - Haloquinoline - Chloroquinoline - Triazolopyridine - Aralkylamine - Aryl chloride - Aryl halide - Benzenoid - Monocyclic benzene moiety - Pyridine - Heteroaromatic compound - Azole - 1,2,4-triazole - Triazole - Tertiary aliphatic amine - Tertiary amine - Azacycle - Organochloride - Organohalogen compound - Amine - Hydrocarbon derivative - Organic nitrogen compound - Organonitrogen compound - Aromatic heteropolycyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as phenylquinolines. These are heterocyclic compounds containing a quinoline moiety substituted with a phenyl group. |
| External Descriptors | Not available |
| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 D2301947 | Certificate of Analysis | Jan 21, 2026 | P412383 |
| D2301948 | Certificate of Analysis | Jan 21, 2026 | P412383 |
| D2301949 | Certificate of Analysis | Jan 21, 2026 | P412383 |
| D2301950 | Certificate of Analysis | Jan 21, 2026 | P412383 |
| D2301951 | Certificate of Analysis | Jan 21, 2026 | P412383 |
| D2301952 | Certificate of Analysis | Jan 21, 2026 | P412383 |
| D2301953 | Certificate of Analysis | Jan 21, 2026 | P412383 |
| D2301954 | Certificate of Analysis | Jan 21, 2026 | P412383 |
| D2301955 | Certificate of Analysis | Jan 21, 2026 | P412383 |
| D2301958 | Certificate of Analysis | Jan 21, 2026 | P412383 |
| Solubilidad | Solubility (25°C) In vitro DMSO: 15 mg/mL (42.75 mM); Ethanol: 3 mg/mL (8.55 mM); Water: ˂1 mg/mL |
|---|---|
| DMSO (mg/ml) Solubilidad máxima | 15 |
| DMSO (mM) Solubilidad máxima | 42.7545319803899 |
| Agua (mg/ml) Solubilidad máxima | ˂1 |
| Peso molecular | 350.800 g/mol |
| XLogP3 | 5.100 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 350.13 Da |
| Monoisotopic Mass | 350.13 Da |
| Topological Polar Surface Area | 33.400 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 439.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
