Phenytoin - Moligand™, 10mM in DMSO , Channel blocker of Na v1.2, CAS No.57-41-0, Channel blocker of Na v1.2

CAS: 57-41-0 Cat. No.: P408649 Peso molecular: 252.27 Número EC: 200-328-6

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Diphenylhydantoin | 5,​5-​diphenyl-2,​4-​imidazolidinedione

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Phenytoin Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.
In vitro

In vivo

Cell Data

cell lines：MM.1S, MM.1R, RPMI8226, U266, RPMI8266, RPMI-Dox40, OPM1 cells, primary MM cells and PBMNCs

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Sinónimos

Diphenylhydantoin | 5, ​5-​diphenyl-2, ​4-​imidazolidinedione

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Phenytoin (Diphenylhydantoin) is an inactive voltage-gated sodium channel stabilizer.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

CHANNEL BLOCKER

Mecanismo de acción

Channel blocker of Na v1.2

Propiedades del producto

• ALogP: 2.5

Nombres e identificadores

• Isómeros SMILES: C1=CC=C(C=C1)C2(C(=O)NC(=O)N2)C3=CC=CC=C3
• Número ONU: 2811
• Grupo de embalaje: I
• Peso molecular: 252.27
• Reaxy-Rn: 384532
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=384532&ln=

Objetivos asociados (humanos)

SCN2A Tclin Sodium channel protein type 2 subunit alpha (2 Activities)

Discover Target: SCN2A

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de fusión (°C): 293-295 °C

Referencias

1. De Bai, Haowei Chen, Lijuan Liu, Nanxi Xiang, Jichuan Zhang, Chengyu Wu, Jiaheng Zhang, Fang Wang.  (2023)  Ionic liquid microcapsules for the topical delivery of pterostilbene: Enhanced transdermal delivery and anti-wrinkle and skin brightening effects.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2023.123842]

2. Yuxuan Lin, Weihua Qin, Yuwei Lu, Mingye Ren, Pan Gao, Feng Xiao, Shaoxia Yang.  (2023)  Reconstructing atomic Fe coordination in the PMS activation process to realize efficient BPA degradation at low temperature.  Environmental Science-Nano,  10  (5): (1284-1296).  [PMID:] [10.1039/D2EN01156E]

3. Wei Li, Zhen Wang, Xiaoyu Wang, Xiaowei Cao, Caili Bi, Lili Jiang, Shuna Cui, Yong Liu.  (2021)  Risk prediction of drug-drug interaction potential of phenytoin and miconazole topical formulations.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:33961833] [10.1016/j.cbi.2021.109498]

4. Mengtian Jia, Yanyan Zhu, Dong Guo, Xiaogang Bi, Xiaohong Hou.  (2020)  Surface molecularly imprinted polymer based on core-shell Fe3O4@MIL-101(Cr) for selective extraction of phenytoin sodium in plasma.  ANALYTICA CHIMICA ACTA,      [PMID:32825905] [10.1016/j.aca.2020.06.075]

5. Jing-Xian Zhang, Mei-Juan Qi, Mei-Zhi Shi, Jun-Jun Chen, Xiang-Qi Zhang, Jiao Yang, Ke-Zhi Zhang, Yong-Long Han, Cheng Guo.  (2018)  Effects of Danhong injection, a traditional Chinese medicine, on nine cytochrome P450 isoforms in vitro.  BIOMEDICAL CHROMATOGRAPHY,  33  (4): (e4454).  [PMID:30520061] [10.1002/bmc.4454]

6. Suqian Xu, Hanxu Zhu, Wenrui Cao, Zhibin Wen, Jinnan Wang, Corvini Philippe François-Xavier, Thomas Wintgens.  (2018)  Cu-Al2O3-g-C3N4 and Cu-Al2O3-C-dots with dual-reaction centres for simultaneous enhancement of Fenton-like catalytic activity and selective H2O2 conversion to hydroxyl radicals.  APPLIED CATALYSIS B-ENVIRONMENTAL,      [PMID:] [10.1016/j.apcatb.2018.04.029]

7. Wang Weixue, Liu Yang, Du Xinjie, Wang Huihui, Ai Yuejie, Liu Qianwei, Wang Xiangke, Chen Zhe.  (2025)  Solvent-free fabrication of ultrathin two-dimensional metal oxides/sulfides in a fixed interlayer by geometric confinement.  Nature Communications,  16  (1): (1-11).  [PMID:39948342] [10.1038/s41467-025-56912-9]