Phloretin (RJC 02792) - Moligand™, 10mM in DMSO , Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1, CAS N, Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1

CAS: 60-82-2 Cat. No.: P408181 Peso molecular: 274.27 Beilstein Registry Number: 1887240 Número EC: 200-488-7
Disponible para pedir
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
NSC 407292, Dihydronaringenin | 1-Propanone, 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)-
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Estado
Price
Qty
1ml
P408181-1ml
1
49,90US$
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 45 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Descripción general

Information

Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
In vitro

Phloretin is a dihydrochalcone found in the bark of pear (Pyrus communis), apple, cherry and other fruit trees. Phloretin inhibits the active transport of glucose into cells by SGLT1 and SGLT2, though the inhibition is weaker than by its glycoside phlorizin. Orally consumed phlorizin is nearly entirely converted into phloretin by hydrolytic enzymes in the small intestine. An important effect of this is the inhibition of glucose absorption by the small intestine and the inhibition of renal glucose reabsorption. Phloretin also inhibits a variety of urea transporters. It induces urea loss and diuresis when coupled with high protein diets.

In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥98%

Specifications

Sinónimos
NSC 407292, Dihydronaringenin | 1-Propanone, 3-(4-hydroxyphenyl)-1-(2, 4, 6-trihydroxyphenyl)-
Especificaciones y pureza
Moligand™, 10mM in DMSO
Mecanismos bioquímicos y fisiológicos
Phloretin (RJC 02792, NSC 407292, Dihydronaringenin) is a dihydrochalcone found in apple tree leaves, which shows beneficial effects on diabetes.
Condiciones de almacenamiento de almacenamiento
Store at -80°C
Enviado en
Dry ice packs + Cold packs
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Grado
Moligand™
Tipo de acción
AGONIST, CHANNEL BLOCKER, INHIBITOR
Mecanismo de acción
Inhibitor of AQP9;Channel blocker of ClC-3;Agonist of TAS2R14;Agonist of TAS2R39;Inhibitor of major facilitator superfamily domain containing 4B;Inhibitor of Sodium-dependent vitamin C transporter 1
Nombres e identificadores
Isómeros SMILES C1=CC(=CC=C1CCC(=O)C2=C(C=C(C=C2O)O)O)O
WGK Alemania 3
Peso molecular 274.27
Beilstein 1887240
Reaxy-Rn 1887240
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1887240&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Objetivos asociados (humanos)
SLC23A1 Tchem Solute carrier family 23 member 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CLCN3 Tchem H(+)/Cl(-) exchange transporter 3 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

1 results found

Lot NumberCertificate TypeFechaArticulo
I2206017Certificate of AnalysisMay 19, 2026 P408181
Propiedades químicas y físicas
SolubilidadSolubility (25°C) In vitro      
Punto de fusión (°C)262°C
Citations of This Product
Referencias
1. Zhixiao Liu, Yuhang Zhao, Mingli Yi, Lintao Liao, Yangyang Huang, Guangqiu Lei, Gao Hu, Mayu Lan, Huiping Li, Zhiming Mi.  (2025)  Preparation of high-permeance polyester nanofiltration membranes utilizing biobased phloretin derivatives for antibiotic separation.  JOURNAL OF MEMBRANE SCIENCE,      [PMID:] [10.1016/j.memsci.2025.124458]
2. Huining Su, Xunan Jing, Heng Sun, Zingcheng Liu, Daquan Wang, Lingjie Meng.  (2025)  Multifunctional Nanocomposite Hydrogel Dressings with Excellent Antibacterial and Angiogenesis Properties for Effective Treatment of Diabetic Wounds.  ACS Applied Materials & Interfaces,      [PMID:40675128] [10.1021/acsami.5c08356]
3. Shouguang Wang, Xiaofei Zhang, Dunmin Zhuang, Lina Dong, Bo Li.  (2025)  Mn2+-coordinated hyaluronic acid modified nanoparticles for phloretin delivery: Breast cancer treatment.  Colloid and Interface Science Communications,      [PMID:] [10.1016/j.colcom.2025.100854]
4. Yu Hu, Hui Guo, Shuai Cheng, Junpeng Sun, Jiaqun Du, Xiaobang Liu, Ying Xiong, Liqing Chen, Chang Liu, Chao Wu, He Tian.  (2023)  Functionalized Cerium Dioxide Nanoparticles with Antioxidative Neuroprotection for Alzheimer’s Disease.  International Journal of Nanomedicine,      [PMID:38026525] [10.2147/IJN.S434873]
5. Meng Zhang, Xue Zhuang, Siqi Li, Yansong Wang, Xiangyu Zhang, Jinlian Li, Dongmei Wu.  (2023)  Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity.  MOLECULES,  29  (1): (66).  [PMID:38202649] [10.3390/molecules29010066]
6. Hong Hu, Liang Chen, Ying Huang, Kunping Wang, Xi Bai, Hongbin Pan.  (2023)  CUT&tag-seq analysis of heat stress response in broiler liver provides novel insights into the improved thermotolerance by dietary phloretin.  ANNALS OF AGRICULTURAL SCIENCE,      [PMID:] [10.1016/j.aoas.2023.02.002]
7. Wang Jie, Jia Jingyu, Sun Jiaju, Pang Xinyue, Li Bairu, Yuan Jiangfeng, Chen Enyan, Li Xin.  (2023)  Trypsin preservation: CsUGT91C1 regulates Trilobatin Biosynthesis in Cucumis sativus during Storage.  PLANT GROWTH REGULATION,  100  (3): (633-646).  [PMID:] [10.1007/s10725-023-00962-w]
8. Yang Liu, Jiali Lin, Tiantian Cheng, Yangjie Liu, Fuliang Han.  (2022)  Methylation, Hydroxylation, Glycosylation and Acylation Affect the Transport of Wine Anthocyanins in Caco-2 Cells.  Foods,  11  (23): (3793).  [PMID:36496602] [10.3390/foods11233793]
9. Mile Li, Mengyi Wang, Shuhui Hu, Jing Sun, Mingqiang Zhu, Yongsheng Ni, Jianlong Wang.  (2022)  Advanced Coatings with Antioxidant and Antibacterial Activity for Kumquat Preservation.  Foods,  11  (15): (2363).  [PMID:35954129] [10.3390/foods11152363]
10. Yingqiao Li, Zhiru Zou, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu.  (2022)  Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury.  DRUG DELIVERY,      [PMID:35903814] [10.1080/10717544.2022.2104957]
11. Zhang Guorong, Wang Qin, Tao Wanyin, Jiang Wei, Elinav Eran, Wang Yucai, Zhu Shu.  (2022)  Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis.  Nature Biomedical Engineering,  (7): (867-881).  [PMID:35798834] [10.1038/s41551-022-00903-4]
12. Fang Li, Yachao Xi, Jianming Jiang, Hao Peng, Bing Li, Jianbo He, Jiangnan Shu, Hua Cui.  (2022)  O-Fluorobenzoic Acid-Mediated Construction of Porous Graphitic Carbon Nitride with Nitrogen Defects for Multicolor Electrochemiluminescence Imaging Sensing.  ANALYTICAL CHEMISTRY,      [PMID:35738019] [10.1021/acs.analchem.2c00702]
13. Zhiru Zou, Shan Wen, Yingqiao Li, Jinyu An, Qian Wu, Le Tong, Xifan Mei, He Tian, Chao Wu.  (2022)  Novel lactoferrin-functionalized manganese-doped silica hollow mesoporous nanoparticles loaded with resveratrol for the treatment of ischemic stroke.  Materials Today Advances,      [PMID:] [10.1016/j.mtadv.2022.100262]
14. Zhang Pengpeng, Zhang Miaomiao, Dong Kaiyu, Zhang Yicong, Yang Shuang, Wang Yuanhong, Jiang Tingfu, Yu Mingming, Lv Zhihua.  (2022)  Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats.  Journal of Ocean University of China,  21  (3): (782-788).  [PMID:] [10.1007/s11802-022-5088-x]
15. Wu Wanbao, Bo Yiyang, Li Deping, Liang Yihong, Zhang Jichuan, Cao Miaomiao, Guo Ruitian, Zhu Zhenye, Ci Lijie, Li Mingyu, Zhang Jiaheng.  (2022)  Safe and Stable Lithium Metal Batteries Enabled by an Amide-Based Electrolyte.  Nano-Micro Letters,  14  (1): (1-14).  [PMID:35020069] [10.1007/s40820-021-00780-7]
16. Xue Jiang, Xiaoyao Liu, Qi Yu, Wenwen Shen, Xifan Mei, He Tian, Chao Wu.  (2021)  Functional resveratrol-biodegradable manganese doped silica nanoparticles for the spinal cord injury treatment.  Materials Today Bio,      [PMID:34938991] [10.1016/j.mtbio.2021.100177]
17. Xiaona Hu, Ziruo Zhou, Lijun Han, Shujing Li, Wei Zhou.  (2020)  Preparation and characterization of phloretin by complexation with cyclodextrins.  NEW JOURNAL OF CHEMISTRY,  44  (14): (5218-5223).  [PMID:] [10.1039/C9NJ06228A]
18. Zerong Li, Wenmei Qiao, Chenghao Wang, Heqiao Wang, Mengchao Ma, Xinyu Han, Jingling Tang.  (2020)  DPPC-coated lipid nanoparticles as an inhalable carrier for accumulation of resveratrol in the pulmonary vasculature, a new strategy for pulmonary arterial hypertension treatment.  DRUG DELIVERY,      [PMID:32397765] [10.1080/10717544.2020.1760962]
19. Zenghui Xie, Yanli Chen, Lanyun Zhang, Xujia Hu.  (2019)  Magnetic molecularly imprinted polymer combined with high performance liquid chromatography for selective extraction and determination of the metabolic content of quercetin in rat plasma.  JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION,      [PMID:31566488] [10.1080/09205063.2019.1675224]
20. Dandan Wang, Liangxiao Zhang, Yueqing Xu, Xin Qi, Xuefang Wang, Xiupin Wang, Qi Zhang, Peiwu Li.  (2019)  Optimization of an Ultrasound-Assisted Extraction for Simultaneous Determination of Antioxidants in Sesame with Response Surface Methodology.  Antioxidants,  (8): (321).  [PMID:31430991] [10.3390/antiox8080321]
21. Yufeng Chen, Fan Xue, Guobin Xia, Zhenlei Zhao, Chun Chen, Yunhong Li, Ying Zhang.  (2019)  Transepithelial transport mechanisms of 7,8-dihydroxyflavone, a small molecular TrkB receptor agonist, in human intestinal Caco-2 cells.  Food & Function,  10  (8): (5215-5227).  [PMID:31384856] [10.1039/C9FO01007F]
22. Yin Ying, Cheng Jiang, Meiling Zhang, Jiye Jin, Shuyu Ge, Xiaodong Wang.  (2019)  Phloretin protects against cardiac damage and remodeling via restoring SIRT1 and anti-inflammatory effects in the streptozotocin-induced diabetic mouse model.  Aging-US,      [PMID:31076562] [10.18632/aging.101954]
23. Meihui Fan, Huafang Ding, Guowen Zhang, Xing Hu, Deming Gong.  (2019)  Relationships of dietary flavonoid structure with its tyrosinase inhibitory activity and affinity.  LWT-FOOD SCIENCE AND TECHNOLOGY,      [PMID:] [10.1016/j.lwt.2019.02.076]
24. Hai-Na Yu, Xin-Yan Liu, Shuai Gao, Bin Sun, Hong-Bo Zheng, Mei Ji, Ai-Xia Cheng, Hong-Xiang Lou.  (2018)  Structural and biochemical characterization of the plant type III polyketide synthases of the liverwort Marchantia paleacea.  PLANT PHYSIOLOGY AND BIOCHEMISTRY,      [PMID:29428820] [10.1016/j.plaphy.2018.01.030]
25. Jiming Wu, Jinghan Li, Jin Zhang, Xinyue Hu, Dahong Yao, Liang Ma, Liang Ouyang, Xinhui Pan, Jian Huang, Ruichao Lin, Jinhui Wang.  (2015)  In silico identification and experimental validation of diuresis compounds from Euphorbia lathyris for potential UT-B inhibitors.  Journal of the Taiwan Institute of Chemical Engineers,      [PMID:] [10.1016/j.jtice.2015.10.045]
26. Siyang Chen, Wenxiu Zhu, Yiqun Zhan, Xiaodong Xia.  (2024)  Antibacterial Activity of Phloretin Against Vibrio parahaemolyticus and Its Application in Seafood.  Foods,  13  (22): (3537).  [PMID:39593953] [10.3390/foods13223537]
27. Cong Liu, Weihua Liu, Qianqian Wang, Chun Wang, Qiuhua Wu.  (2025)  Construction of novel hyper-crosslinked polymers with adjustable hydrophilicity for efficient extraction of nitroimidazoles.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:39855025] [10.1016/j.chroma.2025.465702]
28. Chang Tang, Rui Tong, Guoqing Deng, Jing Yang, Yi Zhang, Zhifeng Cai.  (2024)  Fluorescent carbon dots for highly sensitive diosmetin sensing.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.110362]
29. Xiaomeng Zhang, Xinquan Tian, Junyu Luo, Xiaoyang Wang, Shoupu He, Gaofei Sun, Ruidan Dong, Panhong Dai, Xiao Wang, Zhaoe Pan, Baojun Chen, Daowu Hu, Liru Wang, Baoyin Pang, Aishuang Xing, Guoyong Fu, Baoquan Wang, Jinjie Cui, Lei Ma, Xiongming Du.  (2025)  Identification of UDP-glucosyltransferase involved in the biosynthesis of phloridzin in Gossypium hirsutum.  PLANT JOURNAL,  121  (3): (e17248).  [PMID:39935137] [10.1111/tpj.17248]
30. Jiaqi Wen, Shuling Chen, Le Deng, Xinru Chen, Xiaoyu Jiang, Xing Hu, Deming Gong, Guowen Zhang.  (2024)  Inhibitiory mechanism of phloretin on xanthine oxidase and its synergistic effect with allopurinol and febuxostat.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.104720]
31. Xia Yang, Yun Wang, Yan Sun, Jiali Guo, Zhaojun Geng, Bingyao Wei, Peiqin Li, Guanghui Tang.  (2025)  Integrated transcriptomics and metabolomics revealed the role of the flavonoid pathway in the resistance of Zanthoxylum bungeanum against leaf rust.  SCIENTIA HORTICULTURAE,      [PMID:] [10.1016/j.scienta.2025.113990]
32. Yongsong Zhang, Na Xia, Zhenzhen Ding, Jingjing Song, Yanan Zhang, Cao Li, Xuesong Huang, Zuoshan Feng.  (2025)  Preparation, structural changes and functional properties of the covalent complexes of almond protein and phloretin.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39765300] [10.1016/j.ijbiomac.2024.139322]
33. Yushi Wei, Jianmei Wu, Xi Peng, Xing Hu, Deming Gong, Guowen Zhang.  (2024)  Protein glycosylation inhibitory effects and mechanisms of phloretin and phlorizin.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2024.104971]
34. Jiawei Li, Chengyu Hong, Hao Zhang, Jiaqi Zhang, Ruixue Zhai, Bin Fei, Chao Zhou.  (2024)  Sustainable, transparent, strong toughness, UV resistance, and anti-corrosion properties of cashew shell oil-based waterborne polyurethane network derived from phloretin and sorbitan monooleate-based siloxane.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.151506]
35. Zhou Zhixin, Zhou Cheng, Liu Jia, Yuan Ye, Yao Chundong, Liu Miaodeng, Deng Lixue, Sun Jia, Chen Zuoyu, Wang Lin, Wang Zheng.  (2024)  Tumor specific in situ synthesis of therapeutic agent for precision cancer therapy.  JOURNAL OF NANOBIOTECHNOLOGY,  22  (1): (1-18).  [PMID:39385273] [10.1186/s12951-024-02825-6]
36. Jiaqi Wen, Yijing Liao, Deming Gong, Guowen Zhang.  (2025)  Effects of unsaturated fatty acids on the interaction between phloretin and xanthine oxidase: Inhibitory activity, binding ability and molecular structure.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.106669]
37. Mokhtar Fathi, Kianoosh Zarrinkavyani, Zahra Biranvand, Morteza Aghil Al Abd.  (2025)  Effect of Phloretin on Antioxidant Status, Inflammatory Cytokines, Blood and Biochemical Indices, Cecal Microbial Load, and Growth Performance in Broiler Chickens Subjected to Pulmonary Arterial Hypertension.  POULTRY SCIENCE,      [PMID:40779808] [10.1016/j.psj.2025.105265]
38. Qianqian Liang, Xin Jiang, Dajun Wang, Shumin Zhang, Qifei Hua, Wenzheng Shi.  (2025)  Screening of natural myofibril-bound serine protease inhibitors based on molecular docking and their effects on the quality of surimi gels.  FOOD CHEMISTRY,      [PMID:40580600] [10.1016/j.foodchem.2025.145314]
39. Runze Wang, Wenting Cheng, Hailong Tian, Mengchao Dong, Weifeng He, Xie Wang, Yingying Zou.  (2025)  Thymopentin-integrated self-assembling nanoplatform for enhanced photo-immunotherapy in diabetic wound healing.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:40580559] [10.1016/j.jcis.2025.138264]
40. Teng Xiao, Fanghong Wang, Ye Li, Gaoyang Lin, Xiaochen Wu.  (2025)  Phloretin-loaded selenium nanoparticles for alleviating cisplatin-induced acute kidney injury via inhibition of the cGAS/STING pathway.  International Journal of Pharmaceutics-X,      [PMID:41216270] [10.1016/j.ijpx.2025.100427]
41. Guangyao Li, Weilun Zhang, Zhiwei Deng, Changmei Liu, Zhengshan Luo, Yan Zhang, Zhenbo Yuan, Yijian Rao.  (2025)  Engineering C-glycosyltransferase UGT708A60 to enhance the activity and thermostability for the highly efficient biosynthesis of nothofagin.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.107952]
42. Li Jie, Jiang Enhui, Zhang Mengyang, Pan Chuanying, Lei Chuzhao, Han Lin, Lan Xianyong.  (2025)  Phloretin inhibits ferroptosis by restoring the antioxidant capacity of bovine adipose and muscle cells via the AMPK-PPAR signaling pathway.  Stress Biology,  (1): (74).  [PMID:41354995] [10.1007/s44154-025-00263-4]
43. Dan Yu, Fangmin Chen, Jinliang Deng, Zhe Pu, Xinyao Yang.  (2025)  Serovar-specific lipopolysaccharide modifications induced by phytogenic biocide drive differential bacterial mobility in soil.  APPLIED SOIL ECOLOGY,      [PMID:] [10.1016/j.apsoil.2025.106725]
44. Chong Gao, Wei Liu, Sai-Hu Liu, Shuang Zheng, Chen-Yu Wang, Xu Dai, Li-Hua Lian, Zhen-Yu Cui, Ji-Xing Nan, Yan-Ling Wu.  (2026)  Trigonelline regulates glycolysis and energy metabolism during hepatic fibrosis via Glut-1-HIF-1α axis: Focusing the interaction of macrophages and HSCs.  PHYTOMEDICINE,      [PMID:41579590] [10.1016/j.phymed.2026.157854]
45. Siyang Chen, Jinhui Jia, Jian Du, Ningbo Qin, Xiaodong Xia.  (2026)  Fabrication of a zein-phloretin complex and nanoparticles: interaction mechanism and characterization.  RSC Advances,  16  (9): (7717-7725).  [PMID:41659321] [10.1039/D5RA08898D]
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