PI 828 - ≥99%(HPLC) , CAS No.942289-87-4

CAS: 942289-87-4 Cat. No.: P288720 Peso molecular: 322.36 PubChem CID: 25181195

GRADE & PURITY ≥99%(HPLC)

Synonyms

2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one | LY 294002, 4gamma-NH2 | 8-(4-aminophenyl)-2-morpholino-4H-chromen-4-one | 8-(4-Aminophenyl)-2-(morpholin-4-yl)-4H-chromen-4-one | Q27165404 | DTXSID60648967 | LY294002 4'-NH2 | 8-(4-aminophenyl)-

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Product description：

PI-828 is a dual PI3K and casein kinase 2 (CK2) inhibitor with IC50s of 173 nM, 149 nM, and 1127 nM for p110α, CK2, and CK2α2 in lipid kinase assay, respectively.

Specifications

Sinónimos

2-(4-Morpholinyl)-8-(4-aminopheny)l-4H-1-benzopyran-4-one | LY 294002, 4gamma-NH2 | 8-(4-aminophenyl)-2-morpholino-4H-chromen-4-one | 8-(4-Aminophenyl)-2-(morpholin-4-yl)-4H-chromen-4-one | Q27165404 | DTXSID60648967 | LY294002 4'-NH2 | 8-(4-aminophenyl)-

Especificaciones y pureza

≥99%(HPLC)

Mecanismos bioquímicos y fisiológicos

PI 3-Kinase inhibitor (IC50values are 0.098, 0.183, 0.227 and 1.967μM for p110β, p110α, p110δand p110γrespectively) that displays higher potency thanLY 294002(Cat No. 1130). Can be immobilized onto a solid phase.

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥99%(HPLC)

Nombres e identificadores

• Pubchem Sid: 488200777
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488200777
• Sonrisas canónicas: C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=C(C=C4)N
• IUPAC Name: 8-(4-aminophenyl)-2-morpholin-4-ylchromen-4-one
• InChIKey: WUKMIBOGGXMBAC-UHFFFAOYSA-N
• INCHI: 1S/C19H18N2O3/c20-14-6-4-13(5-7-14)15-2-1-3-16-17(22)12-18(24-19(15)16)21-8-10-23-11-9-21/h1-7,12H,8-11,20H2
• Isómeros SMILES: C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=C(C=C4)N
• PubChem CID: 25181195
• Peso molecular: 322.36

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Benzopyrans
      • Subclass 1-benzopyrans

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Benzopyrans
• Subclass: 1-benzopyrans
• Intermediate Tree Nodes: Not available
• Direct Parent: Chromones
• Alternative Parents: Dialkylarylamines Aniline and substituted anilines Pyranones and derivatives Morpholines Vinylogous amides Heteroaromatic compounds Oxacyclic compounds Dialkyl ethers Azacyclic compounds Primary amines Organopnictogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Chromone - Dialkylarylamine - Aniline or substituted anilines - Pyranone - Monocyclic benzene moiety - Morpholine - Oxazinane - Pyran - Benzenoid - Vinylogous amide - Heteroaromatic compound - Dialkyl ether - Ether - Azacycle - Oxacycle - Organopnictogen compound - Organic nitrogen compound - Organic oxygen compound - Primary amine - Amine - Organooxygen compound - Organonitrogen compound - Organic oxide - Hydrocarbon derivative - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as chromones. These are compounds containing a benzopyran-4-one moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 32.24, Max Conc. mM: 100
• Sensibilidad: light sensitive
• Peso molecular: 322.400 g/mol
• XLogP3: 2.400
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 322.132 Da
• Monoisotopic Mass: 322.132 Da
• Topological Polar Surface Area: 64.800 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 493.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1