Picolinamide - ≥98%(HPLC) , CAS No.1452-77-3

CAS: 1452-77-3 Cat. No.: P138238 Peso molecular: 122.12 Beilstein Registry Number: 22(3/4)311 Número EC: 215-921-5 PubChem CID: 15070

GRADE & PURITY ≥98%(HPLC)

Synonyms

C01950 | NSC 524473 | alpha-Picolinamide | PICOLINAMIDE [INCI] | 2-Carbamoylpyridine | Picolinamide; 2-Pyridinecarboxamide | pyridine amide | s4710 | .alpha.-Pyridinecarboxamide | J-008082 | 2-Pyridinecarboxamide | 2-pyridine-carboxamide | alpha - picolin

Storage

Protected from light,Room temperature,Cool

Shipped In

Normal

Descripción general

Picolinamide is potential inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. It acts as bidentate ligand and forms complexes with lanthanide nitrates, thiocyanates and perchlorates. Picolinamide can be used as template in preparation of molecular imprinting polymer. Picolinamide can be used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in perchloric acid.
Picolinamide was used as template in preparation of molecular imprinting polymer1. Picolinamide was used in a study to evaluate kinetics and mechanism of liberation of picolinamide from chromium(III)-picolinamide complexes in HClO42.

Specifications

Sinónimos

C01950 | NSC 524473 | alpha-Picolinamide | PICOLINAMIDE [INCI] | 2-Carbamoylpyridine | Picolinamide; 2-Pyridinecarboxamide | pyridine amide | s4710 | .alpha.-Pyridinecarboxamide | J-008082 | 2-Pyridinecarboxamide | 2-pyridine-carboxamide | alpha - picolin

Especificaciones y pureza

≥98%(HPLC)

Mecanismos bioquímicos y fisiológicos

Pyridylamide is a potential inhibitor of ADP ribose synthetase. Pyridinamides act as bidentate ligands and form complexes with lanthanide nitrates, thiocyanates and perchlorates.

Condiciones de almacenamiento de almacenamiento

Protected from light, Room temperature, Cool

Enviado en

Normal

Tipo de acción

INHIBITOR

Pureza

≥98%(HPLC)

Nombres e identificadores

• Pubchem Sid: 488182056
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488182056
• Sonrisas canónicas: C1=CC=NC(=C1)C(=O)N
• IUPAC Name: pyridine-2-carboxamide
• InChIKey: IBBMAWULFFBRKK-UHFFFAOYSA-N
• INCHI: 1S/C6H6N2O/c7-6(9)5-3-1-2-4-8-5/h1-4H,(H2,7,9)
• Isómeros SMILES: C1=CC=NC(=C1)C(=O)N
• WGK Alemania: 3
• PubChem CID: 15070
• Peso molecular: 122.12
• Beilstein: 22(3/4)311
• Reaxy-Rn: 109617

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Pyridines and derivatives
      • Subclass Pyridinecarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Pyridines and derivatives
• Subclass: Pyridinecarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridinecarboxamides
• Alternative Parents: 2-heteroaryl carboxamides Heteroaromatic compounds Primary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridinecarboxamide - 2-heteroaryl carboxamide - Heteroaromatic compound - Primary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as pyridinecarboxamides. These are compounds containing a pyridine ring bearing a carboxamide.
• External Descriptors: pyridinecarboxamide

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Punto de ebullición (°C): 143 °C/20 mmHg
• Punto de fusión (°C): 105 °C
• Peso molecular: 122.120 g/mol
• XLogP3: 0.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 122.048 Da
• Monoisotopic Mass: 122.048 Da
• Topological Polar Surface Area: 56.000 Ų
• Heavy Atom Count: 9
• Formal Charge: 0
• Complexity: 114.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Yangyang Sun, Zhuzhu Tang, Yanjun Li, Yongkang Song, Hualei Wang, Dongzhi Wei, Shengli Yang.  (2023)  Identification and evolution of non-traditional nitrilase from Spirosoma linguale DSM 74 with high hydration activity.  BIOORGANIC CHEMISTRY,      [PMID:38185008] [10.1016/j.bioorg.2023.107055]

2. Jassim Mohamed Hamed Al-Kurdhani, Huajun Wang.  (2023)  The Synthesis of Glycerol Carbonate from Glycerol and Carbon Dioxide over Supported CuO-Based Nanoparticle Catalyst.  MOLECULES,  28  (10): (4164).  [PMID:37241907] [10.3390/molecules28104164]

3. Yangyang Sun, Zhuzhu Tang, Tingze Pan, Ke Zhang, Liuzhu Wang, Xingye Zhai, Yiran Jia, Tianqi Yuan, Yujia Qian, Hualei Wang, Dongzhi Wei, Shengli Yang.  (2023)  Alleviating the trade-off by site-guided function switch of nitrilase to nitrile hydratase.  Molecular Catalysis,      [PMID:] [10.1016/j.mcat.2023.113233]

4. Xiaomeng Deng, Wensheng Wei, Zizhen Yan, Zhanguo Zhang, Yuxin Wang, Guangwen Xu, Jianjun Guo, Jinggang Zhao, Lei Shi.  (2024)  Product as additive for facilitating CO2 conversion into cyclic carbonate.  Journal of CO2 Utilization,      [PMID:] [10.1016/j.jcou.2024.102850]

5. Chenyu Wu, Zijian Wang, Xu Han, Xinyi Yu, Changquan Calvin Sun, Zhengzheng Zhou.  (2025)  Simultaneously improving tabletability and solubility of diclofenac by cocrystallization with picolinamide.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:39761707] [10.1016/j.ijpharm.2025.125172]

6. Qinglong Li, Yong Hou, Yunjing Xing, Yumeng Wang, Zhonghao Sun, Zhaocui Sun, Xudong Xu, Longfei Yang, Xiaowei Huo, Guoxu Ma.  (2024)  Directed co-assembly of binary natural small molecules into carrier-free sprayable gel with synergistic multifunctional activity for perishable fruits preservation.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.152104]

7. Ruilu Sun, Wei Li, Minjie Liao, Yiran Yu, Yao Mou, Junfu Ji, Fang Chen, Xiaosong Hu, Lingjun Ma.  (2025)  Piceatannol, a catechol analog of resveratrol, is more effective in improving glucose metabolism disorders.  Food Bioscience,      [PMID:] [10.1016/j.fbio.2025.107348]

8. Peiru Li, Siyuan Guo, Yunan Liu, Yanhong Lin, Tengfeng Xie.  (2025)  Picolinamide Functionalization on Carbon Nitride Edges for Enhanced Charge Separation and Photocatalytic Hydrogen Evolution.  Nanomaterials,  15  (5): (361).  [PMID:40072163] [10.3390/nano15050361]