PIKfyve-IN-1 - ≥95% , CAS No.2857982-26-2

CAS: 2857982-26-2 Cat. No.: P650468 Peso molecular: 331.41 Número EC: 101-535-3

GRADE & PURITY ≥95%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC 50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology

In Vitro

PIKfyve-IN-1 inhibits PIKfyve in PIKfyve enzymatic assay and PIKfyve NanoBRET assay with IC 50 values of 6.9 nM and 4.01 nM, respectively. PIKfyve-IN-1 (0-10 μM) disrupts multiple phases of the lifecycle of coronaviruses: viral replication and viral entry. PIKfyve-IN-1 inhibits MHV replication and SARS-CoV-2 replication with IC 50 values of 23.5 nM and 19.5 nM, respectively. PIKfyve-IN-1 (5 μM) impacts lysosomal homeostasis. MCE has not independently confirmed the accuracy of these methods. They are for reference only. ImmunofluorescenceCell Line: Calu-3 cells Concentration: 1 μM Incubation Time: 1 h Result: Inhibited the uptake of lentivirus pseudotyped with the SARS-CoV-2 spike glycoprotein.

Form:Solid

IC50& Target:IC50: 6.9 nM (PIKfyve)

Specifications

Especificaciones y pureza

≥95%

Mecanismos bioquímicos y fisiológicos

PIKfyve-IN-1 is a highly potent and cell-active chemical probe that inhibits phosphatidylinositol-3phosphate 5-kinase (PIKfyve) with IC 50 value of 6.9 nM. PIKfyve-IN-1 can be used for the research of PIKfyve in virology.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥95%

Nombres e identificadores

• Peso molecular: 331.41