Pioglitazone-d4 (major) - ≥97% , CAS No.1134163-31-7

CAS: 1134163-31-7 Cat. No.: P334350 Peso molecular: 360.46

GRADE & PURITY ≥97%

Synonyms

AD-4833-d4 | DTXSID90649422 | 5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy-d4]phenyl]methyl]-2,4-thiazolidinedione | Pioglitazone-d4 (major) | 111025-46-8 (unlabeled) | 5-[[4-[1,1,2,2-tetradeuterio-2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Pioglitazone-d4 is a labeled thiazolidinedione, which activates PPARγ and to a lesser extent PPARα. Studies show that Pioglitazone-d4 increases splanchnic and peripheral glucose uptake in NIIDM. It is known that Pioglitazone-d4 modulates insulin-sensitive genes which control glucose and lipid metabolism in a variety of tissues such as muscle cells, adipose tissue and the liver. Alternate studies show that Pioglitazone-d4 activates Akt, while upregulating cPLA2 and Cox-2. Pioglitazone-d4 is effective in interfering with androgen binding on aromatase in human granulosa cells, which inhibits estrogen synthesis.

Specifications

Sinónimos

AD-4833-d4 | DTXSID90649422 | 5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy-d4]phenyl]methyl]-2, 4-thiazolidinedione | Pioglitazone-d4 (major) | 111025-46-8 (unlabeled) | 5-[[4-[1, 1, 2, 2-tetradeuterio-2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1, 3-thiazolidine-2, 4

Especificaciones y pureza

≥97%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Pureza

≥97%

Nombres e identificadores

• Sonrisas canónicas: CCC1=CN=C(C=C1)CCOC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
• IUPAC Name: 5-[[4-[1,1,2,2-tetradeuterio-2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• InChIKey: HYAFETHFCAUJAY-YQUBHJMPSA-N
• INCHI: 1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)/i9D2,10D2
• Isómeros SMILES: [2H]C([2H])(C1=NC=C(C=C1)CC)C([2H])([2H])OC2=CC=C(C=C2)CC3C(=O)NC(=O)S3
• CAS alternativo: unlabelled: 111025-46-8
• Peso molecular: 360.46
• Reaxy-Rn: 3595485
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3595485&ln=

Propiedades químicas y físicas

• Solubilidad: Soluble in DMSO (hot) and THF (hot)
• Punto de fusión (°C): 179-182° C