Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥98%(GC) Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 16 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Application:
Pyrfenidone is used for:
1、 As a postoperative eye drop for rabbits, analyze its anti fibrotic effect and improve glaucoma filtration surgery.
2、As an anti scarring agent, check if it affects the foreign body reaction after implantation of glaucoma drainage device (GDD) in rabbits.
3、Test its anti fibrotic potential in primary culture of human orbital fibroblasts (hOF).
4、 As tumor necrosis factor (TNF) α) Inhibitors, studying their role in hypoxia.
Explanation:
Pyrfenidone (5-methyl-1-phenyl-2- [1H] - pyridone) is a synthesized pyridine derivative.
| ALogP | 1.9 |
|---|
| Pubchem Sid | 488183324 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488183324 |
| Sonrisas canónicas | CC1=CN(C(=O)C=C1)C2=CC=CC=C2 |
| IUPAC Name | 5-methyl-1-phenylpyridin-2-one |
| InChIKey | ISWRGOKTTBVCFA-UHFFFAOYSA-N |
| INCHI | 1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3 |
| Isómeros SMILES | CC1=CN(C(=O)C=C1)C2=CC=CC=C2 |
| WGK Alemania | 3 |
| RTECS | UV1148200 |
| Peso molecular | 185.22 |
| Beilstein | 21(5)7,197 |
| Reaxy-Rn | 1526549 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1526549&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organoheterocyclic compounds |
| Clase | Pyridines and derivatives |
| Subclass | Hydropyridines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Pyridinones |
| Alternative Parents | Methylpyridines Dihydropyridines Benzene and substituted derivatives Heteroaromatic compounds Lactams Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | Dihydropyridine - Pyridinone - Methylpyridine - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Lactam - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Aromatic heteromonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as pyridinones. These are compounds containing a pyridine ring, which bears a ketone. |
| External Descriptors | ring assembly - pyridone |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Jun 09, 2026 | P129335 | |
| Certificate of Analysis | May 09, 2026 | P129335 | |
| Certificate of Analysis | Apr 03, 2026 | P129335 | |
| Certificate of Analysis | Apr 03, 2026 | P129335 | |
| Certificate of Analysis | Jan 26, 2026 | P129335 | |
| Certificate of Analysis | Jan 26, 2026 | P129335 | |
| Certificate of Analysis | Sep 09, 2025 | P129335 | |
| Certificate of Analysis | Aug 27, 2025 | P129335 | |
| Certificate of Analysis | Aug 27, 2025 | P129335 | |
| Certificate of Analysis | Aug 27, 2025 | P129335 | |
| Certificate of Analysis | Aug 27, 2025 | P129335 | |
| Certificate of Analysis | Aug 27, 2025 | P129335 | |
| Certificate of Analysis | May 09, 2025 | P129335 | |
| Certificate of Analysis | May 09, 2025 | P129335 | |
| Certificate of Analysis | May 09, 2025 | P129335 | |
| Certificate of Analysis | May 09, 2025 | P129335 | |
| Certificate of Analysis | May 09, 2025 | P129335 | |
| Certificate of Analysis | Mar 04, 2025 | P129335 | |
| Certificate of Analysis | Jul 11, 2024 | P129335 | |
| Certificate of Analysis | Jul 10, 2024 | P129335 | |
| Certificate of Analysis | Jul 10, 2024 | P129335 | |
| Certificate of Analysis | Jul 10, 2024 | P129335 | |
| Certificate of Analysis | Jul 10, 2024 | P129335 | |
| Certificate of Analysis | Jul 10, 2024 | P129335 | |
| Certificate of Analysis | Jul 07, 2023 | P129335 | |
| Certificate of Analysis | Jul 07, 2023 | P129335 | |
| Certificate of Analysis | Jul 07, 2023 | P129335 | |
| Certificate of Analysis | Jul 07, 2023 | P129335 | |
| Certificate of Analysis | Jul 07, 2023 | P129335 | |
| Certificate of Analysis | Sep 17, 2022 | P129335 | |
| Certificate of Analysis | Sep 17, 2022 | P129335 | |
| Certificate of Analysis | Jul 18, 2022 | P129335 | |
| Certificate of Analysis | Jul 18, 2022 | P129335 | |
| Certificate of Analysis | Jul 18, 2022 | P129335 | |
| Certificate of Analysis | Jul 18, 2022 | P129335 | |
| Certificate of Analysis | Jun 24, 2022 | P129335 | |
| Certificate of Analysis | Jan 25, 2022 | P129335 | |
| Certificate of Analysis | Dec 08, 2021 | P129335 | |
| Certificate of Analysis | Dec 08, 2021 | P129335 |
| Solubilidad | Soluble in water (>10 mg/ml at 60 °C), chloroform, DMSO (>20 mg/ml), ethanol, and DMF. |
|---|---|
| Punto de fusión (°C) | 107.0 to 111.0 °C |
| Peso molecular | 185.220 g/mol |
| XLogP3 | 1.900 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 1 |
| Rotatable Bond Count | 1 |
| Exact Mass | 185.084 Da |
| Monoisotopic Mass | 185.084 Da |
| Topological Polar Surface Area | 20.300 Ų |
| Heavy Atom Count | 14 |
| Formal Charge | 0 |
| Complexity | 285.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Yin Zhang, Ranran Yu, Cheng Zhao, Jiawei Liang, Yixuan Zhang, Haochen Su, Jing Zhao, Hao Wu, Shijin Xu, Ziying Zhang, Lei Wang, Xiaoping Zou, Yun Zhu, Shu Zhang, Ying Lv. (2023) CAFs Homologous Biomimetic Liposome Bearing BET Inhibitor and Pirfenidone Synergistically Promoting Antitumor Efficacy in Pancreatic Ductal Adenocarcinoma. Advanced Science, [PMID:37968249] [10.1002/advs.202305279] |
| 2. Huang Ting, Lin Ruyi, Su Yuanqin, Sun Hao, Zheng Xixi, Zhang Jinsong, Lu Xiaoyan, Zhao Baiqin, Jiang Xinchi, Huang Lingling, Li Ni, Shi Jing, Fan Xiaohui, Xu Donghang, Zhang Tianyuan, Gao Jianqing. (2023) Efficient intervention for pulmonary fibrosis via mitochondrial transfer promoted by mitochondrial biogenesis. Nature Communications, 14 (1): (1-15). [PMID:37723135] [10.1038/s41467-023-41529-7] |
| 3. Xionghua Sun, Mei Zhu, Wei Xia, Xihan Xu, Jian Zhang, Xiaogang Jiang. (2023) Total sesquiterpenoids from Eupatorium lindleyanum DC. attenuate bleomycin-induced lung fibrosis by suppressing myofibroblast transition. FITOTERAPIA, [PMID:37315715] [10.1016/j.fitote.2023.105567] |
| 4. Xiaohua Xie, Xiaofeng Wu, Dongsheng Zhao, Ying Liu, Qiyue Du, Yitian Li, Yaping Xu, Yuhang Li, Yan Qiu, Yungang Yang. (2022) Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway. PHARMACOLOGICAL RESEARCH, [PMID:36435270] [10.1016/j.phrs.2022.106577] |
| 5. Tingting Li, Dong Han, Zhongxian Li, Mengqi Qiu, Yuting Zhu, Kai Li, Jiawei Xiang, Huizhen Sun, Yahong Shi, Tun Yan, Xiaoli Shi, Qiang Zhang. (2022) Hydroxysafflor Yellow A Phytosomes Administered via Intervaginal Space Injection Ameliorate Pulmonary Fibrosis in Mice. Pharmaceuticals, 15 (11): (1394). [PMID:36422524] [10.3390/ph15111394] |
| 6. Qi Fang, Shaoyu Liu, Jiangyu Cui, Ruiyue Zhao, Qian Han, Peng Hou, Youcai Li, Jie Lv, Xiaoyao Zhang, Qun Luo, Xinlu Wang. (2022) Mesoporous Polydopamine Loaded Pirfenidone Target to Fibroblast Activation Protein for Pulmonary Fibrosis Therapy. Frontiers in Bioengineering and Biotechnology, [PMID:35957641] [10.3389/fbioe.2022.920766] |
| 7. Jian-Li Qiu, Guo-Feng Zhang, Yu-Na Chai, Xiao-Yan Han, Hai-Tao Zheng, Xiang-Feng Li, Fei Duan, Ling-Yan Chen. (2022) Ligustrazine Attenuates Liver Fibrosis by Targeting miR-145 Mediated Transforming Growth Factor-β/Smad Signaling in an Animal Model of Biliary Atresia. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 381 (3): (257-265). [PMID:35398813] [10.1124/jpet.121.001020] |
| 8. Wei Sun, Zhe-li Jiang, Lei Zhou, Rui-min Chen, Zhe Wang, Wan-shu Li, Shuo-min Jiang, Guo-xin Hu, Rui-jie Chen. (2015) Determination and pharmacokinetic study of pirfenidone in rat plasma by UPLC–MS/MS. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, [PMID:25596380] [10.1016/j.jchromb.2014.12.027] |
| 9. Canchao Jia, Minjuan Yang, Guanlin Xiao, Zhihao Zeng, Lingjie Li, Yangxue Li, Jieyi Jiang, Aili Xu, Jinyan Qiu, Ruiyin Tang, Dongmei Li, Dezheng Jia, Canhui Xie, Guangying Wu, Dake Cai, Xiaoli Bi. (2024) ESL Attenuates BLM-induced IPF in Mice: Dual Mediation of the TLR4/NF-κB and TGF-β1/PI3K/Akt/FOXO3a Pathways. PHYTOMEDICINE, [PMID:38972238] [10.1016/j.phymed.2024.155545] |
| 10. Su Qiyan, Feng Yingyue, Guo Jin, Cui Xi, Zhu Jiarui, Yang Jumei, Zhang Sigong. (2025) Pirfenidone alleviates interstitial lung disease in mice by inhibiting neutrophil extracellular trap formation and NLRP3 inflammasome activation. CLINICAL AND EXPERIMENTAL IMMUNOLOGY, [PMID:40117382] [10.1093/cei/uxaf019] |
| 11. Shuyu Ge, Zhenghong Guo, Ting Xiao, Pingping Sun, Bo Yang, Yin Ying. (2024) Qingfei Tongluo Mixture Attenuates Bleomycin-Induced Pulmonary Inflammation and Fibrosis through mTOR-Dependent Autophagy in Rats. MEDIATORS OF INFLAMMATION, [PMID:38361765] [10.1155/2024/5573353] |
| 12. Luo Ye, Xu Chang-jun, Ai Xing-hui, Li Yu-ping, Zhu Xing, Yang Chang-fu. (2025) Mechanism study of the effects of astragaloside IV and quercetin on idiopathic pulmonary fibrosis. Journal of Natural Medicines, [PMID:40307659] [10.1007/s11418-025-01896-5] |
| 13. Zhi Yang, Yizheng Yao, Xi Chen, Victoria Madigan, Shanrui Pu, Xianqun Fan, Jun Pu, Fengfeng Bei. (2025) Cross-species tropism of AAV.CPP.16 in the respiratory tract and its gene therapies against pulmonary fibrosis and viral infection. Cell Reports Medicine, [PMID:40409263] [10.1016/j.xcrm.2025.102144] |
| 14. Jia-Yi Dou, Chen-Yu Wang, Sai-Hu Liu, Chong Gao, Shuang Zheng, Li-Hua Lian, Zhen-Yu Cui, Ji-Xing Nan, Yan-Ling Wu. (2026) Pterostilbene ameliorates pulmonary fibrogenesis and inflammation targeting IL-23/ATP6V0D2 pathway: remodel local microenvironment of alveolar epithelial cells and fibroblasts. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:41576569] [10.1016/j.intimp.2026.116256] |
| 15. Qianqian Li, Yufang Ni, Zhaoyang Li, Yuanxia Zou, Huaiying Guo, Honglian Wang, Qiong Zhang, Li Wang, Jianchun Li. (2026) Curdione alleviates renal fibrosis through Fblim1-dependent inhibition of the TGF-β1/Smad3 signaling pathway. JOURNAL OF NUTRITIONAL BIOCHEMISTRY, [PMID:41771455] [10.1016/j.jnutbio.2026.110333] |
| 16. Yonghu Chen, Linying Hu, Qiang Fu, Hongzhen Chen, Zhe Jiang, Xuezheng Li. (2026) Ginseng stem and leaf saponins attenuates pulmonary fibrosis by regulating TFAM–mtDNA homeostasis and suppressing ZBP1-mediated PANoptosis. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:] [10.1016/j.jep.2026.121597] |
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