PluriSIón nº 1 (NSC 14613) - ≥98% , CAS No.91396-88-2

CAS: 91396-88-2 Cat. No.: P129781 Peso molecular: 213.24 Número EC: 804-702-5

GRADE & PURITY ≥98%

Synonyms

DTXSID30279924 | Q63396122 | SR-01000195348 | I0975 | C12H11N3O | HMS3870N13 | NSC14613 | NSC-14613 | N'-phenylpyridine-4-carbohydrazide | PluriSln1 | SW219761-1 | AC-32930 | NCGC00371137-01 | PluriSln 1 | AKOS002347507 | Pluripotent cell-specific inhibit

Storage

Conservar a 2-8°C

Shipped In

Hielo húmedo

Descripción general

PluriSIn #1 es un inhibidor de la estearoil-coA desaturasa 1 (SCD1), capaz de eliminar selectivamente hPSCs
Un inhibidor de la SCD1 e inductor de la apoptosis.

Specifications

Sinónimos

DTXSID30279924 | Q63396122 | SR-01000195348 | I0975 | C12H11N3O | HMS3870N13 | NSC14613 | NSC-14613 | N'-phenylpyridine-4-carbohydrazide | PluriSln1 | SW219761-1 | AC-32930 | NCGC00371137-01 | PluriSln 1 | AKOS002347507 | Pluripotent cell-specific inhibit

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

PluriSln 1 es un inhibidor de la estearoil-CoA desaturasa 1 (SCD1). Es útil para eliminar células madre pluripotentes humanas indiferenciadas (hPSCs) de cultivo mediante la inducción selectiva de apoptosis en estas células. Además, la pluriSln 1 induce la

Condiciones de almacenamiento de almacenamiento

Conservar a 2-8°C

Enviado en

Hielo húmedo

Tipo de acción

INHIBITOR

Nota

Siempre que sea posible, prepare y utilice las soluciones el mismo día. Sin embargo, si necesita preparar soluciones madre con antelación, le recomendamos que almacene la solución como alícuotas en viales herméticamente cerrados a -20°C. Por lo general, podrán utilizarse durante un mes. Antes de su uso, y antes de abrir el vial, le recomendamos que deje que el producto se equilibre a temperatura ambiente durante al menos 1 hora. ¿Necesita más consejos sobre solubilidad, uso y manipulación? Visite nuestra página de preguntas frecuentes (FAQ) para obtener más información.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2
• IUPAC Name: N'-phenylpyridine-4-carbohydrazide
• InChIKey: HUDWXDLBWRHCKO-UHFFFAOYSA-N
• INCHI: 1S/C12H11N3O/c16-12(10-6-8-13-9-7-10)15-14-11-4-2-1-3-5-11/h1-9,14H,(H,15,16)
• Isómeros SMILES: C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2
• WGK Alemania: 3
• Peso molecular: 213.24
• Reaxy-Rn: 172867
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=172867&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Pyridines and derivatives
      • Subclass Pyridinecarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Pyridines and derivatives
• Subclass: Pyridinecarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridinecarboxylic acids and derivatives
• Alternative Parents: Phenylhydrazines Heteroaromatic compounds Carboxylic acid hydrazides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridine carboxylic acid or derivatives - Phenylhydrazine - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Carboxylic acid hydrazide - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as pyridinecarboxylic acids and derivatives. These are compounds containing a pyridine ring bearing a carboxylic acid group or a derivative thereof.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO 43 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
• Sensibilidad: Heat Sensitive
• Punto de fusión (°C): 189 °C
• Peso molecular: 213.230 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 213.09 Da
• Monoisotopic Mass: 213.09 Da
• Topological Polar Surface Area: 54.000 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 220.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1