PluriSIn #1 (NSC 14613) - 10mM in DMSO , CAS No.91396-88-2

CAS: 91396-88-2 Cat. No.: P426900 Peso molecular: 213.24 Número EC: 804-702-5

GRADE & PURITY 10mM in DMSO

Synonyms

DTXSID30279924 | Q63396122 | SR-01000195348 | I0975 | C12H11N3O | HMS3870N13 | NSC14613 | NSC-14613 | N'-phenylpyridine-4-carbohydrazide | PluriSln1 | SW219761-1 | AC-32930 | NCGC00371137-01 | PluriSln 1 | AKOS002347507 | Pluripotent cell-specific inhibit

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

PluriSIn #1 is an inhibitor of the stearoyl-coA desaturase 1 (SCD1), which is able to selectively eliminate hPSCs
A SCD1 inhibitor and apoptosis inducer.

Specifications

Sinónimos

DTXSID30279924 | Q63396122 | SR-01000195348 | I0975 | C12H11N3O | HMS3870N13 | NSC14613 | NSC-14613 | N'-phenylpyridine-4-carbohydrazide | PluriSln1 | SW219761-1 | AC-32930 | NCGC00371137-01 | PluriSln 1 | AKOS002347507 | Pluripotent cell-specific inhibit

Especificaciones y pureza

10mM in DMSO

Mecanismos bioquímicos y fisiológicos

PluriSln 1 is an inhibitor of stearoyl-CoA desaturase 1 (SCD1). It is useful for eliminating undifferentiated human pluripotent stem cells (hPSCs) from culture by selectively inducing apoptosis in these cells. Additionally, pluriSln 1 induces endoplasmic

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Nombres e identificadores

• Sonrisas canónicas: C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2
• IUPAC Name: N'-phenylpyridine-4-carbohydrazide
• InChIKey: HUDWXDLBWRHCKO-UHFFFAOYSA-N
• INCHI: 1S/C12H11N3O/c16-12(10-6-8-13-9-7-10)15-14-11-4-2-1-3-5-11/h1-9,14H,(H,15,16)
• Isómeros SMILES: C1=CC=C(C=C1)NNC(=O)C2=CC=NC=C2
• WGK Alemania: 3
• Peso molecular: 213.24
• Reaxy-Rn: 172867
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=172867&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Clase Pyridines and derivatives
      • Subclass Pyridinecarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Clase: Pyridines and derivatives
• Subclass: Pyridinecarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyridinecarboxylic acids and derivatives
• Alternative Parents: Phenylhydrazines Heteroaromatic compounds Carboxylic acid hydrazides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Pyridine carboxylic acid or derivatives - Phenylhydrazine - Monocyclic benzene moiety - Benzenoid - Heteroaromatic compound - Carboxylic acid hydrazide - Carboxylic acid derivative - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organooxygen compound - Organonitrogen compound - Organopnictogen compound - Organic oxygen compound - Aromatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as pyridinecarboxylic acids and derivatives. These are compounds containing a pyridine ring bearing a carboxylic acid group or a derivative thereof.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de acción

Propiedades químicas y físicas

• Sensibilidad: Heat Sensitive
• Punto de fusión (°C): 189 °C
• Peso molecular: 213.230 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 213.09 Da
• Monoisotopic Mass: 213.09 Da
• Topological Polar Surface Area: 54.000 Ų
• Heavy Atom Count: 16
• Formal Charge: 0
• Complexity: 220.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1