Pomaglumetad methionil hydrochloride - ≥98% , CAS No.635318-26-2

CAS: 635318-26-2 Cat. No.: P648455 Peso molecular: 402.87 PubChem CID: 66903228

GRADE & PURITY ≥98%

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research

In Vitro

Pomaglumetad methionil (LY2140023) is a high-affinity peptide transporter 1 (PEPT1) substrate with a K m value of ~30 µM. LY2140023 is active against [ 14 C]Gly-Sar with an IC 50 value of 0.018 mM. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pomaglumetad methionil (LY2140023; orally; 3-300 mg/kg; once daily for 7 days) dose-dependent increases the levels of the dopamine metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Fischer rats (approximately 250 g) Dosage: 3 mg/kg, 10 mg/kg, and 300 mg/kg Administration: Orally; once daily for 7 days Result: Dose-dependent increased the levels of the dopamine metabolites DOPAC and HVA.

Form:Solid

IC50& Target:mGluR2 mGluR3

Specifications

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Pomaglumetad methionil hydrochloride (LY2140023 hydrochloride) is an orally active, methionine prodrug of the selective mGlu2/3 receptor agonist LY404039. Pomaglumetad methionil hydrochloride has the potential for schizophrenia research.

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

AGONIST

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CSCCC(C(=O)NC1(CS(=O)(=O)C2C1C2C(=O)O)C(=O)O)N.Cl
• IUPAC Name: (1R,4S,5S,6S)-4-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-2,2-dioxo-2\u03bb6-thiabicyclo[3.1.0]hexane-4,6-dicarboxylic acid;hydrochloride
• InChIKey: KTYRTJLEXFSWRJ-LBMFEJOUSA-N
• INCHI: 1S/C12H18N2O7S2.ClH/c1-22-3-2-5(13)9(15)14-12(11(18)19)4-23(20,21)8-6(7(8)12)10(16)17;/h5-8H,2-4,13H2,1H3,(H,14,15)(H,16,17)(H,18,19);1H/t5-,6+,7+,8-,12-;/m0./s1
• Isómeros SMILES: CSCC[C@@H](C(=O)N[C@]1(CS(=O)(=O)[C@@H]2[C@H]1[C@H]2C(=O)O)C(=O)O)N.Cl
• PubChem CID: 66903228
• Peso molecular: 402.87

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Peptides
          • Level6 Dipeptides

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Peptides
• Direct Parent: Dipeptides
• Alternative Parents: Methionine and derivatives N-acyl-L-alpha-amino acids Alpha amino acid amides Thianes Cyclopropanecarboxylic acids N-acyl amines Dicarboxylic acids and derivatives Thiolanes Sulfones Secondary carboxylic acid amides Amino acids Sulfenyl compounds Carboxylic acids Dialkylthioethers Carbonyl compounds Organic oxides Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives Hydrochlorides
• Molecular Framework: Aliphatic heteropolycyclic compounds
• Substituents: Alpha-dipeptide - Methionine or derivatives - N-acyl-alpha-amino acid - N-acyl-alpha amino acid or derivatives - N-acyl-l-alpha-amino acid - Alpha-amino acid amide - Alpha-amino acid or derivatives - Cyclopropanecarboxylic acid - Cyclopropanecarboxylic acid or derivatives - Dicarboxylic acid or derivatives - Fatty amide - N-acyl-amine - Thiane - Fatty acyl - Thiolane - Sulfone - Amino acid - Secondary carboxylic acid amide - Carboxamide group - Amino acid or derivatives - Thioether - Organoheterocyclic compound - Dialkylthioether - Sulfenyl compound - Carboxylic acid - Hydrocarbon derivative - Organopnictogen compound - Primary aliphatic amine - Amine - Organic oxygen compound - Organic nitrogen compound - Organic oxide - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Primary amine - Hydrochloride - Carbonyl group - Aliphatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as dipeptides. These are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: DMSO : 25 mg/mL (62.05 mM; Need ultrasonic)