Pomalidomide-PEG₆-Alkyne

Cat. No.: P487817

Synonyms

Protein degrader building block for PROTAC research, Crosslinker–E3 Ligase ligand conjugate, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-4,7,10,13,16,19-hexaoxadocos-21-ynamide, Template for synthesis of targeted protein degrader

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

Description

Protein degrader builiding block Pomalidomide-PEG6-Alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Especificaciones

Sinónimos

Protein degrader building block for PROTAC research, Crosslinker–E3 Ligase ligand conjugate, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-4,7,10,13,16,19-hexaoxadocos-21-ynamide, Template for synthesis of targeted protein degrader

Información jurídica

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.