Pomalidomide-PEG₄-Azide - ≥95% , CAS No.2271036-47-4

CAS: 2271036-47-4 Cat. No.: P463556 Peso molecular: 518.52 PubChem CID: 145714646

GRADE & PURITY ≥95%

Synonyms

14-Azido-N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-3,6,9,12-tetraoxatetradecanamide, Crosslinker-E3 ligase ligand conjugate, Protein degrader building block for PROTAC research, Pomalidomide conjugate, Template for synthesis of targe

Storage

Protected from light,Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Application

230

Descripción general

Description

Protein degrader builiding block Pomalidomide-PEG4-Azide enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant azide, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Sinónimos

14-Azido-N-(2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxoisoindolin-4-yl)-3, 6, 9, 12-tetraoxatetradecanamide, Crosslinker-E3 ligase ligand conjugate, Protein degrader building block for PROTAC research, Pomalidomide conjugate, Template for synthesis of targe

Especificaciones y pureza

≥95%

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Argon charged

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥95%

Nombres e identificadores

• Pubchem Sid: 504773593
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504773593
• Sonrisas canónicas: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCOCCN=[N+]=[N-]
• PubChem CID: 145714646
• Peso molecular: 518.52

Propiedades químicas y físicas

• Sensibilidad: Light sensitive
• Peso molecular: 518.500 g/mol
• XLogP3: 1.200
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 11
• Rotatable Bond Count: 17
• Exact Mass: 518.213 Da
• Monoisotopic Mass: 518.213 Da
• Topological Polar Surface Area: 147.000 Ų
• Heavy Atom Count: 37
• Formal Charge: 0
• Complexity: 851.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1