Pomalidomide-PEG₂-butyl alkyne - ≥95%

Cat. No.: P463550

GRADE & PURITY ≥95%

Synonyms

Protein degrader building block for PROTAC research, Crosslinker−E3 Ligase ligand conjugate, Pomalidomide conjugate, Template for synthesis of targeted protein degrader, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2-(2-(oct-7-yn-1-ylox

Storage

Store at 2-8°C

Shipped In

Wet ice

Descripción general

Description

Protein degrader builiding block Pomalidomide-PEG2-butyl alkyne enables the synthesis of molecules fortargeted protein degradation andPROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blockswith a pendant alkyne, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Specifications

Sinónimos

Protein degrader building block for PROTAC research, Crosslinker−E3 Ligase ligand conjugate, Pomalidomide conjugate, Template for synthesis of targeted protein degrader, N-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)-2-(2-(oct-7-yn-1-ylox

Especificaciones y pureza

≥95%

Información jurídica

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥95%

Preguntas frecuentes

What is the purity of this product?

This product is supplied at ≥95% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.